|Automated, scalable culture of human embryonic stem cells in feeder‐free conditions|
RJ Thomas, D Anderson, A Chandra, NM Smith, LE Young, D Williams, ...
Biotechnology and Bioengineering 102 (6), 1636-1644, 2009
|The effect of three-dimensional co-culture of hepatocytes and hepatic stellate cells on key hepatocyte functions in vitro|
RJ Thomas, R Bhandari, DA Barrett, AJ Bennett, JR Fry, D Powe, ...
Cells Tissues Organs 181 (2), 67-79, 2005
|Expansion of human mesenchymal stem cells on microcarriers|
CJ Hewitt, K Lee, AW Nienow, RJ Thomas, M Smith, CR Thomas
Biotechnology letters 33 (11), 2325, 2011
|Current understanding and challenges in bioprocessing of stem cell-based therapies for regenerative medicine|
E Ratcliffe, RJ Thomas, DJ Williams
British medical bulletin 100 (1), 137, 2011
|Application of process quality engineering techniques to improve the understanding of the in vitro processing of stem cells for therapeutic use|
RJ Thomas, PC Hourd, DJ Williams
Journal of biotechnology 136 (3-4), 148-155, 2008
|Manufacture of a human mesenchymal stem cell population using an automated cell culture platform|
RJ Thomas, A Chandra, Y Liu, PC Hourd, PP Conway, DJ Williams
Cytotechnology 55 (1), 31-39, 2007
|Hepatic stellate cells on poly (DL-lactic acid) surfaces control the formation of 3D hepatocyte co-culture aggregates in vitro.|
RJ Thomas, A Bennett, B Thomson, KM Shakesheff
European cells & materials 11, 16-26; discussion 26, 2006
|Precision manufacturing for clinical-quality regenerative medicines|
DJ Williams, RJ Thomas, PC Hourd, A Chandra, E Ratcliffe, Y Liu, ...
Philosophical Transactions of the Royal Society A: Mathematical, Physical …, 2012
|Automated, serum-free production of CTX0E03: a therapeutic clinical grade human neural stem cell line|
RJ Thomas, AD Hope, P Hourd, M Baradez, EA Miljan, JD Sinden, ...
Biotechnology letters 31 (8), 1167-1172, 2009
|A Novel Automated Bioreactor for Scalable Process Optimisation of Haematopoietic Stem Cell Culture|
E Ratcliffe, KE Glen, VL Workman, AJ Stacey, RJ Thomas
Journal of Biotechnology, 2012
|Human‐induced pluripotent stem cells generate light responsive retinal organoids with variable and nutrient‐dependent efficiency|
D Hallam, G Hilgen, B Dorgau, L Zhu, M Yu, S Bojic, P Hewitt, M Schmitt, ...
Stem Cells 36 (10), 1535-1551, 2018
|Cell culture automation and quality engineering: a necessary partnership to develop optimized manufacturing processes for cell-based therapies|
RJ Thomas, A Chandra, PC Hourd, DJ Williams
JALA: Journal of the Association for Laboratory Automation 13 (3), 152-158, 2008
|Mesenchymal stem cell isolation from human umbilical cord tissue: understanding and minimizing variability in cell yield for process optimization|
A Iftimia-Mander, P Hourd, R Dainty, RJ Thomas
Biopreservation and biobanking 11 (5), 291-298, 2013
|Investigating the feasibility of scale up and automation of human induced pluripotent stem cells cultured in aggregates in feeder free conditions|
FAC Soares, A Chandra, RJ Thomas, RA Pedersen, L Vallier, DJ Williams
Journal of biotechnology 173, 53-58, 2014
|Comparability: manufacturing, characterization and controls, report of a UK regenerative medicine platform pluripotent stem cell platform workshop, trinity hall, cambridge, 14 …|
DJ Williams, R Archer, P Archibald, I Bantounas, R Baptista, R Barker, ...
Regenerative medicine 11 (5), 483-492, 2016
|A quality-by-design approach to risk reduction and optimization for human embryonic stem cell cryopreservation processes|
PD Mitchell, E Ratcliffe, P Hourd, DJ Williams, RJ Thomas
Tissue Engineering Part C: Methods 20 (12), 941-950, 2014
|Production of erythrocytes from directly isolated or Delta1 Notch ligand expanded CD34+ hematopoietic progenitor cells: process characterization, monitoring and implications …|
KE Glen, VL Workman, F Ahmed, E Ratcliffe, AJ Stacey, RJ Thomas
Cytotherapy 15 (9), 1106-1117, 2013
|Translating cell-based regenerative medicines from research to successful products: challenges and solutions|
Y Bayon, AA Vertès, V Ronfard, M Egloff, S Snykers, GF Salinas, ...
Tissue Engineering Part B: Reviews 20 (4), 246-256, 2014
|The productivity limit of manufacturing blood cell therapy in scalable stirred bioreactors|
R Bayley, F Ahmed, K Glen, M McCall, A Stacey, R Thomas
Journal of tissue engineering and regenerative medicine 12 (1), e368-e378, 2018
|Application of response surface methodology to maximize the productivity of scalable automated human embryonic stem cell manufacture|
E Ratcliffe, P Hourd, J Guijarro-Leach, E Rayment, DJ Williams, ...
Regenerative Medicine 8 (1), 39-48, 2013