Immune-responsive gene 1 protein links metabolism to immunity by catalyzing itaconic acid production A Michelucci, T Cordes, J Ghelfi, A Pailot, N Reiling, O Goldmann, T Binz, ... Proceedings of the National Academy of Sciences 110 (19), 7820-7825, 2013 | 993 | 2013 |
Immunoresponsive gene 1 and itaconate inhibit succinate dehydrogenase to modulate intracellular succinate levels T Cordes, M Wallace, A Michelucci, AS Divakaruni, SC Sapcariu, C Sousa, ... Journal of Biological Chemistry 291 (27), 14274-14284, 2016 | 430 | 2016 |
Itaconic acid: the surprising role of an industrial compound as a mammalian antimicrobial metabolite T Cordes, A Michelucci, K Hiller Annual review of nutrition 35, 451-473, 2015 | 181 | 2015 |
Serine restriction alters sphingolipid diversity to constrain tumour growth T Muthusamy, T Cordes, MK Handzlik, L You, EW Lim, J Gengatharan, ... Nature 586 (7831), 790-795, 2020 | 176 | 2020 |
Increased serine and one-carbon pathway metabolism by PKCλ/ι deficiency promotes neuroendocrine prostate cancer M Reina-Campos, JF Linares, A Duran, T Cordes, A L'Hermitte, MG Badur, ... Cancer Cell 35 (3), 385-400. e9, 2019 | 157 | 2019 |
Inhibition of the mitochondrial pyruvate carrier protects from excitotoxic neuronal death AS Divakaruni, M Wallace, C Buren, K Martyniuk, AY Andreyev, E Li, ... Journal of Cell Biology 216 (4), 1091-1105, 2017 | 152 | 2017 |
A biomolecular isolation framework for eco-systems biology H Roume, E El Muller, T Cordes, J Renaut, K Hiller, P Wilmes The ISME journal 7 (1), 110-121, 2013 | 113 | 2013 |
Itaconate modulates tricarboxylic acid and redox metabolism to mitigate reperfusion injury T Cordes, A Lucas, AS Divakaruni, AN Murphy, P Cabrales, CM Metallo Molecular metabolism 32, 122-135, 2020 | 102 | 2020 |
Development of a scale-down model of hydrodynamic stress to study the performance of an industrial CHO cell line under simulated production scale bioreactor conditions JB Sieck, T Cordes, WE Budach, MH Rhiel, Z Suemeghy, C Leist, ... Journal of biotechnology 164 (1), 41-49, 2013 | 100 | 2013 |
ATF4-induced metabolic reprograming is a synthetic vulnerability of the p62-deficient tumor stroma JF Linares, T Cordes, A Duran, M Reina-Campos, T Valencia, CS Ahn, ... Cell metabolism 26 (6), 817-829. e6, 2017 | 93 | 2017 |
PKCλ/ι loss induces autophagy, oxidative phosphorylation, and NRF2 to promote liver cancer progression Y Kudo, M Sugimoto, E Arias, H Kasashima, T Cordes, JF Linares, ... Cancer cell 38 (2), 247-262. e11, 2020 | 86 | 2020 |
Oncogenic R132 IDH1 mutations limit NADPH for de novo lipogenesis through (D) 2-hydroxyglutarate production in fibrosarcoma cells MG Badur, T Muthusamy, SJ Parker, S Ma, SK McBrayer, T Cordes, ... Cell reports 25 (4), 1018-1026. e4, 2018 | 82 | 2018 |
Quantifying intermediary metabolism and lipogenesis in cultured mammalian cells using stable isotope tracing and mass spectrometry T Cordes, CM Metallo High-throughput metabolomics: methods and protocols, 219-241, 2019 | 50 | 2019 |
NTFD—a stand-alone application for the non-targeted detection of stable isotope-labeled compounds in GC/MS data K Hiller, A Wegner, D Weindl, T Cordes, CM Metallo, JK Kelleher, ... Bioinformatics 29 (9), 1226-1228, 2013 | 46 | 2013 |
Itaconate alters succinate and coenzyme a metabolism via inhibition of mitochondrial complex II and methylmalonyl-CoA mutase T Cordes, CM Metallo Metabolites 11 (2), 117, 2021 | 41 | 2021 |
Mesaconate is synthesized from itaconate and exerts immunomodulatory effects in macrophages W He, A Henne, M Lauterbach, E Geißmar, F Nikolka, C Kho, A Heinz, ... Nature metabolism 4 (5), 524-533, 2022 | 39 | 2022 |
Bridging the gap between non-targeted stable isotope labeling and metabolic flux analysis D Weindl, T Cordes, N Battello, SC Sapcariu, X Dong, A Wegner, K Hiller Cancer & metabolism 4, 1-14, 2016 | 35 | 2016 |
Disruption of the sodium-dependent citrate transporter SLC13A5 in mice causes alterations in brain citrate levels and neuronal network excitability in the hippocampus C Henke, K Töllner, RM van Dijk, N Miljanovic, T Cordes, F Twele, S Bröer, ... Neurobiology of disease 143, 105018, 2020 | 33 | 2020 |
The lactate-NAD+ axis activates cancer-associated fibroblasts by downregulating p62 JF Linares, T Cid-Diaz, A Duran, M Osrodek, A Martinez-Ordoñez, ... Cell reports 39 (6), 2022 | 27 | 2022 |
Establishment of patient-derived succinate dehydrogenase–deficient gastrointestinal stromal tumor models for predicting therapeutic response M Yebra, S Bhargava, A Kumar, AM Burgoyne, CM Tang, H Yoon, ... Clinical Cancer Research 28 (1), 187-200, 2022 | 25 | 2022 |