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Thekla Cordes
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Immune-responsive gene 1 protein links metabolism to immunity by catalyzing itaconic acid production
A Michelucci, T Cordes, J Ghelfi, A Pailot, N Reiling, O Goldmann, T Binz, ...
Proceedings of the National Academy of Sciences 110 (19), 7820-7825, 2013
9892013
Immunoresponsive gene 1 and itaconate inhibit succinate dehydrogenase to modulate intracellular succinate levels
T Cordes, M Wallace, A Michelucci, AS Divakaruni, SC Sapcariu, C Sousa, ...
Journal of Biological Chemistry 291 (27), 14274-14284, 2016
4302016
Itaconic acid: the surprising role of an industrial compound as a mammalian antimicrobial metabolite
T Cordes, A Michelucci, K Hiller
Annual review of nutrition 35, 451-473, 2015
1792015
Serine restriction alters sphingolipid diversity to constrain tumour growth
T Muthusamy, T Cordes, MK Handzlik, L You, EW Lim, J Gengatharan, ...
Nature 586 (7831), 790-795, 2020
1742020
Increased serine and one-carbon pathway metabolism by PKCλ/ι deficiency promotes neuroendocrine prostate cancer
M Reina-Campos, JF Linares, A Duran, T Cordes, A L'Hermitte, MG Badur, ...
Cancer Cell 35 (3), 385-400. e9, 2019
1552019
Inhibition of the mitochondrial pyruvate carrier protects from excitotoxic neuronal death
AS Divakaruni, M Wallace, C Buren, K Martyniuk, AY Andreyev, E Li, ...
Journal of Cell Biology 216 (4), 1091-1105, 2017
1512017
A biomolecular isolation framework for eco-systems biology
H Roume, E El Muller, T Cordes, J Renaut, K Hiller, P Wilmes
The ISME journal 7 (1), 110-121, 2013
1132013
Development of a scale-down model of hydrodynamic stress to study the performance of an industrial CHO cell line under simulated production scale bioreactor conditions
JB Sieck, T Cordes, WE Budach, MH Rhiel, Z Suemeghy, C Leist, ...
Journal of biotechnology 164 (1), 41-49, 2013
992013
Itaconate modulates tricarboxylic acid and redox metabolism to mitigate reperfusion injury
T Cordes, A Lucas, AS Divakaruni, AN Murphy, P Cabrales, CM Metallo
Molecular metabolism 32, 122-135, 2020
972020
ATF4-induced metabolic reprograming is a synthetic vulnerability of the p62-deficient tumor stroma
JF Linares, T Cordes, A Duran, M Reina-Campos, T Valencia, CS Ahn, ...
Cell metabolism 26 (6), 817-829. e6, 2017
932017
PKCλ/ι loss induces autophagy, oxidative phosphorylation, and NRF2 to promote liver cancer progression
Y Kudo, M Sugimoto, E Arias, H Kasashima, T Cordes, JF Linares, ...
Cancer cell 38 (2), 247-262. e11, 2020
862020
Oncogenic R132 IDH1 mutations limit NADPH for de novo lipogenesis through (D) 2-hydroxyglutarate production in fibrosarcoma cells
MG Badur, T Muthusamy, SJ Parker, S Ma, SK McBrayer, T Cordes, ...
Cell reports 25 (4), 1018-1026. e4, 2018
802018
Quantifying intermediary metabolism and lipogenesis in cultured mammalian cells using stable isotope tracing and mass spectrometry
T Cordes, CM Metallo
High-throughput metabolomics: methods and protocols, 219-241, 2019
502019
NTFD—a stand-alone application for the non-targeted detection of stable isotope-labeled compounds in GC/MS data
K Hiller, A Wegner, D Weindl, T Cordes, CM Metallo, JK Kelleher, ...
Bioinformatics 29 (9), 1226-1228, 2013
462013
Itaconate alters succinate and coenzyme a metabolism via inhibition of mitochondrial complex II and methylmalonyl-CoA mutase
T Cordes, CM Metallo
Metabolites 11 (2), 117, 2021
412021
Mesaconate is synthesized from itaconate and exerts immunomodulatory effects in macrophages
W He, A Henne, M Lauterbach, E Geißmar, F Nikolka, C Kho, A Heinz, ...
Nature metabolism 4 (5), 524-533, 2022
392022
Bridging the gap between non-targeted stable isotope labeling and metabolic flux analysis
D Weindl, T Cordes, N Battello, SC Sapcariu, X Dong, A Wegner, K Hiller
Cancer & metabolism 4, 1-14, 2016
342016
Disruption of the sodium-dependent citrate transporter SLC13A5 in mice causes alterations in brain citrate levels and neuronal network excitability in the hippocampus
C Henke, K Töllner, RM van Dijk, N Miljanovic, T Cordes, F Twele, S Bröer, ...
Neurobiology of disease 143, 105018, 2020
332020
The lactate-NAD+ axis activates cancer-associated fibroblasts by downregulating p62
JF Linares, T Cid-Diaz, A Duran, M Osrodek, A Martinez-Ordoñez, ...
Cell reports 39 (6), 2022
272022
Establishment of patient-derived succinate dehydrogenase–deficient gastrointestinal stromal tumor models for predicting therapeutic response
M Yebra, S Bhargava, A Kumar, AM Burgoyne, CM Tang, H Yoon, ...
Clinical Cancer Research 28 (1), 187-200, 2022
252022
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