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Alexander C Huang
Alexander C Huang
Verified email at pennmedicine.upenn.edu
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Cited by
Cited by
Year
Exosomal PD-L1 contributes to immunosuppression and is associated with anti-PD-1 response
G Chen, AC Huang, W Zhang, G Zhang, M Wu, W Xu, Z Yu, J Yang, ...
Nature 560 (7718), 382-386, 2018
20832018
Deep immune profiling of COVID-19 patients reveals distinct immunotypes with therapeutic implications
D Mathew, JR Giles, AE Baxter, DA Oldridge, AR Greenplate, JE Wu, ...
Science 369 (6508), eabc8511, 2020
15452020
T-cell invigoration to tumour burden ratio associated with anti-PD-1 response
AC Huang, MA Postow, RJ Orlowski, R Mick, B Bengsch, S Manne, W Xu, ...
Nature 545 (7652), 60-65, 2017
14802017
Determinants of response and resistance to CD19 chimeric antigen receptor (CAR) T cell therapy of chronic lymphocytic leukemia
JA Fraietta, SF Lacey, EJ Orlando, I Pruteanu-Malinici, M Gohil, S Lundh, ...
Nature medicine 24 (5), 563-571, 2018
13432018
TOX transcriptionally and epigenetically programs CD8+ T cell exhaustion
O Khan, JR Giles, S McDonald, S Manne, SF Ngiow, KP Patel, MT Werner, ...
Nature 571 (7764), 211-218, 2019
11062019
Epigenetic stability of exhausted T cells limits durability of reinvigoration by PD-1 blockade
KE Pauken, MA Sammons, PM Odorizzi, S Manne, J Godec, O Khan, ...
Science 354 (6316), 1160-1165, 2016
11062016
Tumor interferon signaling regulates a multigenic resistance program to immune checkpoint blockade
JL Benci, B Xu, Y Qiu, TJ Wu, H Dada, C Twyman-Saint Victor, L Cucolo, ...
Cell 167 (6), 1540-1554. e12, 2016
10232016
Developmental relationships of four exhausted CD8+ T cell subsets reveals underlying transcriptional and epigenetic landscape control mechanisms
JC Beltra, S Manne, MS Abdel-Hakeem, M Kurachi, JR Giles, Z Chen, ...
Immunity 52 (5), 825-841. e8, 2020
5782020
A single dose of neoadjuvant PD-1 blockade predicts clinical outcomes in resectable melanoma
AC Huang, RJ Orlowski, X Xu, R Mick, SM George, PK Yan, S Manne, ...
Nature medicine 25 (3), 454-461, 2019
5612019
TCF-1-centered transcriptional network drives an effector versus exhausted CD8 T cell-fate decision
Z Chen, Z Ji, SF Ngiow, S Manne, Z Cai, AC Huang, J Johnson, ...
Immunity 51 (5), 840-855. e5, 2019
4872019
CD8+ T cells contribute to survival in patients with COVID-19 and hematologic cancer
EM Bange, NA Han, P Wileyto, JY Kim, S Gouma, J Robinson, ...
Nature medicine 27 (7), 1280-1289, 2021
4172021
Pathological response and survival with neoadjuvant therapy in melanoma: a pooled analysis from the International Neoadjuvant Melanoma Consortium (INMC)
AM Menzies, RN Amaria, EA Rozeman, AC Huang, MT Tetzlaff, ...
Nature medicine 27 (2), 301-309, 2021
3072021
Epigenomic-guided mass cytometry profiling reveals disease-specific features of exhausted CD8 T cells
B Bengsch, T Ohtani, O Khan, M Setty, S Manne, S O’Brien, PF Gherardini, ...
Immunity 48 (5), 1029-1045. e5, 2018
2792018
A decade of checkpoint blockade immunotherapy in melanoma: understanding the molecular basis for immune sensitivity and resistance
AC Huang, R Zappasodi
Nature immunology 23 (5), 660-670, 2022
2302022
Efficacy and safety of hydroxychloroquine vs placebo for pre-exposure SARS-CoV-2 prophylaxis among health care workers: a randomized clinical trial
BS Abella, EL Jolkovsky, BT Biney, JE Uspal, MC Hyman, I Frank, ...
JAMA internal medicine 181 (2), 195-202, 2021
2102021
Deep immune profiling of MIS-C demonstrates marked but transient immune activation compared with adult and pediatric COVID-19
LA Vella, JR Giles, AE Baxter, DA Oldridge, C Diorio, L Kuri-Cervantes, ...
Science immunology 6 (57), eabf7570, 2021
1922021
IL-12p70–producing patient DC vaccine elicits Tc1-polarized immunity
BM Carreno, M Becker-Hapak, A Huang, M Chan, A Alyasiry, WR Lie, ...
The Journal of clinical investigation 123 (8), 3383-3394, 2013
1792013
Non-conventional inhibitory CD4+ Foxp3− PD-1hi T cells as a biomarker of immune checkpoint blockade activity
R Zappasodi, S Budhu, MD Hellmann, MA Postow, Y Senbabaoglu, ...
Cancer cell 33 (6), 1017-1032. e7, 2018
1512018
Tumor-infiltrating mast cells are associated with resistance to anti-PD-1 therapy
R Somasundaram, T Connelly, R Choi, H Choi, A Samarkina, L Li, ...
Nature communications 12 (1), 346, 2021
1222021
UPenn COVID Processing Unit
D Mathew, JR Giles, AE Baxter, DA Oldridge, AR Greenplate, JE Wu, ...
Deep immune profiling of COVID-19 patients reveals distinct immunotypes with …, 2020
962020
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