| The mechanism of sirtuin 2–mediated exacerbation of alpha-synuclein toxicity in models of Parkinson disease RM De Oliveira, H Vicente Miranda, L Francelle, R Pinho, ÉM Szegö, ... PLoS biology 15 (3), e2000374, 2017 | 167 | 2017 |
| Nuclear localization and phosphorylation modulate pathological effects of alpha-synuclein R Pinho, I Paiva, KG Jerčić, L Fonseca-Ornelas, E Gerhardt, C Fahlbusch, ... Human molecular genetics 28 (1), 31-50, 2019 | 150 | 2019 |
| Fasudil attenuates aggregation of α-synuclein in models of Parkinson’s disease L Tatenhorst, K Eckermann, V Dambeck, L Fonseca-Ornelas, H Walle, ... Acta neuropathologica communications 4, 1-17, 2016 | 135 | 2016 |
| Small molecule-mediated stabilization of vesicle-associated helical α-synuclein inhibits pathogenic misfolding and aggregation L Fonseca-Ornelas, SE Eisbach, M Paulat, K Giller, CO Fernández, ... Nature communications 5 (1), 5857, 2014 | 99 | 2014 |
| Environmental and genetic factors support the dissociation between α-synuclein aggregation and toxicity A Villar-Piqué, T Lopes da Fonseca, R Sant’Anna, ÉM Szegö, ... Proceedings of the National Academy of Sciences 113 (42), E6506-E6515, 2016 | 89 | 2016 |
| Refolding of helical soluble α‐synuclein through transient interaction with lipid interfaces M Rovere, JB Sanderson, L Fonseca‐Ornelas, DS Patel, T Bartels FEBS letters 592 (9), 1464-1472, 2018 | 45 | 2018 |
| E46K-like α-synuclein mutants increase lipid interactions and disrupt membrane selectivity M Rovere, AE Powers, H Jiang, JC Pitino, L Fonseca-Ornelas, DS Patel, ... Journal of Biological Chemistry 294 (25), 9799-9812, 2019 | 40 | 2019 |
| Synphilin suppresses α‐synuclein neurotoxicity in a Parkinson's disease Drosophila model RH Vargas, LF Ornelas, IL González, JR Escovar, M Zurita, E Reynaud genesis 49 (5), 392-402, 2011 | 36 | 2011 |
| Altered conformation of α-synuclein drives dysfunction of synaptic vesicles in a synaptosomal model of Parkinson’s disease L Fonseca-Ornelas, T Viennet, M Rovere, H Jiang, L Liu, S Nuber, ... Cell reports 36 (1), 2021 | 24 | 2021 |
| Dynamic physiological α-synuclein S129 phosphorylation is driven by neuronal activity N Ramalingam, SX Jin, TE Moors, L Fonseca-Ornelas, K Shimanaka, ... npj Parkinson's Disease 9 (1), 4, 2023 | 20 | 2023 |
| Burial of the polymorphic residue 129 in amyloid fibrils of prion stop mutants L Skora, L Fonseca-Ornelas, RV Hofele, D Riedel, K Giller, J Watzlawik, ... Journal of Biological Chemistry 288 (5), 2994-3002, 2013 | 20 | 2013 |
| Small‐Molecule‐Induced Soluble Oligomers of α‐Synuclein with Helical Structure L Fonseca‐Ornelas, C Schmidt, AR Camacho‐Zarco, CO Fernandez, ... Chemistry–A European Journal 23 (53), 13010-13014, 2017 | 18 | 2017 |
| Parkinson-causing mutations in LRRK2 impair the physiological tetramerization of endogenous α-synuclein in human neurons L Fonseca-Ornelas, JMS Stricker, S Soriano-Cruz, B Weykopf, U Dettmer, ... npj Parkinson's Disease 8 (1), 118, 2022 | 11 | 2022 |
| Small molecule-mediated stabilization of vesicle-associated helical α-synuclein inhibits pathogenic misfolding and aggregation.[Internet]. Nat. Commun 5: 5857 L Fonseca-Ornelas, SE Eisbach, M Paulat, K Giller, CO Fernández, ... | 5 | 2014 |
| The protonation state of histidine 111 regulates the aggregation of the evolutionary most conserved region of the human prion protein L Fonseca‐Ornelas, M Zweckstetter Protein Science 25 (8), 1563-1567, 2016 | 3 | 2016 |
| Modulating the aggregation of alpha-synuclein and prion protein with small molecules. L Fonseca-Ornelas Georg-August-Universität Göttingen, 2016 | 2 | 2016 |
| Reconstitution of Helical Soluble α-Synuclein through Transient Interaction with Lipid Interfaces M Rovere, JB Sanderson, L Fonseca-Ornelas, T Bartels bioRxiv, 202994, 2017 | | 2017 |
| The Parkinson-Causing LRRK2 Mutation G2019S Impairs the Physiological Tetramerization of Α-Synuclein in Human Neurons L Fonseca-Ornelas, J Stricker, U Dettmer, C Muratore, D Selkoe Available at SSRN 3775871, 0 | | |
| Altered Conformation of α-Synuclein Drives Malfunction of Synaptic Vesicles in a Model of Parkinson's Disease L Fonseca-Ornelas, T Viennet, M Rovere, H Jiang, L Liu, S Nuber, ... Available at SSRN 3684858, 0 | | |
Tiago Fleming OuteiroUniversity Medical Center Goettingen, Goettingen, GermanyBestätigte E-Mail-Adresse bei gwdg.de
