| A novel pathogenic pathway of immune activation detectable before clinical onset in Huntington's disease M Björkqvist, EJ Wild, J Thiele, A Silvestroni, R Andre, N Lahiri, ... The Journal of experimental medicine 205 (8), 1869-1877, 2008 | 715 | 2008 |
| Huntingtin modulates transcription, occupies gene promoters in vivo, and binds directly to DNA in a polyglutamine-dependent manner CL Benn, T Sun, G Sadri-Vakili, KN McFarland, DP DiRocco, GJ Yohrling, ... Journal of Neuroscience 28 (42), 10720-10733, 2008 | 277 | 2008 |
| Physiology of hyperuricemia and urate-lowering treatments CL Benn, P Dua, R Gurrell, P Loudon, A Pike, RI Storer, C Vangjeli Frontiers in medicine 5, 160, 2018 | 276 | 2018 |
| Histones associated with downregulated genes are hypo-acetylated in Huntington's disease models G Sadri-Vakili, B Bouzou, CL Benn, MO Kim, P Chawla, RP Overland, ... Human molecular genetics 16 (11), 1293-1306, 2007 | 239 | 2007 |
| Molecular and functional variation in iPSC-derived sensory neurons J Schwartzentruber, S Foskolou, H Kilpinen, J Rodrigues, K Alasoo, ... Nature genetics 50 (1), 54-61, 2018 | 198 | 2018 |
| (R)-PFI-2 is a potent and selective inhibitor of SETD7 methyltransferase activity in cells D Barsyte-Lovejoy, F Li, MJ Oudhoff, JH Tatlock, A Dong, H Zeng, H Wu, ... Proceedings of the National Academy of Sciences 111 (35), 12853-12858, 2014 | 181 | 2014 |
| SAHA decreases HDAC 2 and 4 levels in vivo and improves molecular phenotypes in the R6/2 mouse model of Huntington's disease M Mielcarek, CL Benn, SA Franklin, DL Smith, B Woodman, PA Marks, ... PloS one 6 (11), e27746, 2011 | 171 | 2011 |
| Contribution of nuclear and extranuclear polyQ to neurological phenotypes in mouse models of Huntington's disease CL Benn, C Landles, H Li, AD Strand, B Woodman, K Sathasivam, SH Li, ... Human molecular genetics 14 (20), 3065-3078, 2005 | 153 | 2005 |
| Characterizing human stem cell–derived sensory neurons at the single-cell level reveals their ion channel expression and utility in pain research GT Young, A Gutteridge, HDE Fox, AL Wilbrey, L Cao, LT Cho, AR Brown, ... Molecular Therapy 22 (8), 1530-1543, 2014 | 147 | 2014 |
| Decreased association of the transcription factor Sp1 with genes downregulated in Huntington's disease AS Chen-Plotkin, G Sadri-Vakili, GJ Yohrling, MW Braveman, CL Benn, ... Neurobiology of disease 22 (2), 233-241, 2006 | 138 | 2006 |
| Sp1 is up-regulated in cellular and transgenic models of Huntington disease, and its reduction is neuroprotective Z Qiu, F Norflus, B Singh, MK Swindell, R Buzescu, M Bejarano, R Chopra, ... Journal of Biological Chemistry 281 (24), 16672-16680, 2006 | 130 | 2006 |
| Forebrain adenosine A2A receptors contribute to L-3, 4-dihydroxyphenylalanine-induced dyskinesia in hemiparkinsonian mice D Xiao, E Bastia, YH Xu, CL Benn, JHJ Cha, TS Peterson, JF Chen, ... Journal of Neuroscience 26 (52), 13548-13555, 2006 | 104 | 2006 |
| Genetic knock-down of HDAC7 does not ameliorate disease pathogenesis in the R6/2 mouse model of Huntington's disease CL Benn, R Butler, L Mariner, J Nixon, H Moffitt, M Mielcarek, B Woodman, ... PLoS One 4 (6), e5747, 2009 | 74 | 2009 |
| Glutamate receptor abnormalities in the YAC128 transgenic mouse model of Huntington’s disease CL Benn, EJ Slow, LA Farrell, R Graham, Y Deng, MR Hayden, JHJ Cha Neuroscience 147 (2), 354-372, 2007 | 72 | 2007 |
| Optimisation of region-specific reference gene selection and relative gene expression analysis methods for pre-clinical trials of Huntington's disease CL Benn, H Fox, GP Bates Molecular neurodegeneration 3, 1-17, 2008 | 65 | 2008 |
| 14 The polyglutamine diseases GP Bates, C Benn Huntington's disease, 429, 2002 | 62 | 2002 |
| A novel disorder reveals clathrin heavy chain-22 is essential for human pain and touch development MS Nahorski, L Al-Gazali, J Hertecant, DJ Owen, GHH Borner, YC Chen, ... Brain 138 (8), 2147-2160, 2015 | 58 | 2015 |
| Mechanisms of distribution of mouse β-galactosidase in the adult GM1-gangliosidosis brain MLD Broekman, LA Tierney, C Benn, P Chawla, JH Cha, M Sena-Esteves Gene therapy 16 (2), 303-308, 2009 | 40 | 2009 |
| Environmental enrichment reduces neuronal intranuclear inclusion load but has no effect on messenger RNA expression in a mouse model of Huntington disease CL Benn, R Luthi-Carter, A Kuhn, G Sadri-Vakili, KL Blankson, SC Dalai, ... Journal of Neuropathology & Experimental Neurology 69 (8), 817-827, 2010 | 39 | 2010 |
| Subcellular localization and formation of huntingtin aggregates correlates with symptom onset and progression in a Huntington’s disease model C Landles, RE Milton, N Ali, R Flomen, M Flower, F Schindler, ... Brain communications 2 (2), fcaa066, 2020 | 37 | 2020 |
