Francis Chan
Francis Chan
Professor, Duke University School of Medicine
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Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018
L Galluzzi, I Vitale, SA Aaronson, JM Abrams, D Adam, P Agostinis, ...
Cell Death & Differentiation 25 (3), 486-541, 2018
Phosphorylation-driven assembly of the RIP1-RIP3 complex regulates programmed necrosis and virus-induced inflammation
YS Cho, S Challa, D Moquin, R Genga, TD Ray, M Guildford, FKM Chan
Cell 137 (6), 1112-1123, 2009
A domain in TNF receptors that mediates ligand-independent receptor assembly and signaling
FKM Chan, HJ Chun, L Zheng, RM Siegel, KL Bui, MJ Lenardo
Science 288 (5475), 2351-2354, 2000
Mature T lymphocyte apoptosis—immune regulation in a dynamic and unpredictable antigenic environment
M Lenardo, FKM Chan, F Hornung, H McFarland, R Siegel, J Wang, ...
Annual review of immunology 17 (1), 221-253, 1999
The RIP1/RIP3 necrosome forms a functional amyloid signaling complex required for programmed necrosis
J Li, T McQuade, AB Siemer, J Napetschnig, K Moriwaki, YS Hsiao, ...
Cell 150 (2), 339-350, 2012
Essential versus accessory aspects of cell death: recommendations of the NCCD 2015
L Galluzzi, BS Pedro, I Vitale, SA Aaronson, JM Abrams, D Adam, ...
Cell Death & Differentiation 22 (1), 58-73, 2015
Detection of necrosis by release of lactate dehydrogenase activity
FKM Chan, K Moriwaki, MJ De Rosa
Immune Homeostasis: Methods and Protocols, 65-70, 2013
Fas preassociation required for apoptosis signaling and dominant inhibition by pathogenic mutations
RM Siegel, JK Frederiksen, DA Zacharias, FKM Chan, M Johnson, ...
Science 288 (5475), 2354-2357, 2000
Inherited human Caspase 10 mutations underlie defective lymphocyte and dendritic cell apoptosis in autoimmune lymphoproliferative syndrome type II
J Wang, L Zheng, A Lobito, FKM Chan, J Dale, M Sneller, X Yao, JM Puck, ...
Cell 98 (1), 47-58, 1999
A role for tumor necrosis factor receptor-2 and receptor-interacting protein in programmed necrosis and antiviral responses
FKM Chan, J Shisler, JG Bixby, M Felices, L Zheng, M Appel, J Orenstein, ...
Journal of Biological Chemistry 278 (51), 51613-51621, 2003
RIP3 induces apoptosis independent of pronecrotic kinase activity
P Mandal, SB Berger, S Pillay, K Moriwaki, C Huang, H Guo, JD Lich, ...
Molecular cell 56 (4), 481-495, 2014
CTLA-4-Mediated inhibition of early events of T cell proliferation
MC Brunner, CA Chambers, FKM Chan, J Hanke, A Winoto, JP Allison
The Journal of Immunology 162 (10), 5813-5820, 1999
Necroptosis: mechanisms and relevance to disease
L Galluzzi, O Kepp, FKM Chan, G Kroemer
Annual Review of Pathology: Mechanisms of Disease 12, 103-130, 2017
The multifaceted role of Fas signaling in immune cell homeostasis and autoimmunity
RM Siegel, F Ka-Ming Chan, HJ Chun, MJ Lenardo
Nature immunology 1 (6), 469-474, 2000
Identification of Human and Mouse p19, a Novel CDK4 and CDK6 Inhibitor with Homology to p16ink4
FKM Chan, J Zhang, L Cheng, DN Shapiro, A Winoto
Molecular and cellular biology 15 (5), 2682-2688, 1995
Functional complementation between FADD and RIP1 in embryos and lymphocytes
H Zhang, X Zhou, T McQuade, J Li, FKM Chan, J Zhang
Nature 471 (7338), 373-376, 2011
RIP3: a molecular switch for necrosis and inflammation
K Moriwaki, FKM Chan
Genes & development 27 (15), 1640-1649, 2013
A role for the orphan steroid receptor Nur77 in apoptosis accompanying antigen-induced negative selection
BJ Cainan, S Szychowski, FKM Chan, D Cado, A Winoto
Immunity 3 (3), 273-282, 1995
Functional redundancy of the Nur77 and Nor‐1 orphan steroid receptors in T‐cell apoptosis
LEC Cheng, FKM Chan, D Cado, A Winoto
The EMBO journal, 1997
Programmed necrosis in the cross talk of cell death and inflammation
FKM Chan, NF Luz, K Moriwaki
Annual review of immunology 33, 79-106, 2015
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