Gerhard F Ecker
Gerhard F Ecker
Professor of Pharmacoinformatics, University of Vienna
Verified email at - Homepage
Cited by
Cited by
Coexistence of passive and carrier-mediated processes in drug transport
K Sugano, M Kansy, P Artursson, A Avdeef, S Bendels, L Di, GF Ecker, ...
Nature reviews Drug discovery 9 (8), 597-614, 2010
On the relationship between feature selection and classification accuracy
A Janecek, W Gansterer, M Demel, G Ecker
New challenges for feature selection in data mining and knowledge discovery …, 2008
Open PHACTS: semantic interoperability for drug discovery
AJ Williams, L Harland, P Groth, S Pettifer, C Chichester, EL Willighagen, ...
Drug discovery today 17 (21-22), 1188-1198, 2012
Resveratrol analogues as selective cyclooxygenase-2 inhibitors: synthesis and structure–activity relationship
M Murias, N Handler, T Erker, K Pleban, G Ecker, P Saiko, T Szekeres, ...
Bioorganic & medicinal chemistry 12 (21), 5571-5578, 2004
Adverse outcome pathways: opportunities, limitations and open questions
M Leist, A Ghallab, R Graepel, R Marchan, R Hassan, SH Bennekou, ...
Archives of Toxicology 91, 3477-3505, 2017
Prediction of drug–ABC-transporter interaction—Recent advances and future challenges
F Montanari, GF Ecker
Advanced drug delivery reviews 86, 17-26, 2015
Diazepam-bound GABAA receptor models identify new benzodiazepine binding-site ligands
L Richter, C De Graaf, W Sieghart, Z Varagic, M Mörzinger, IJP De Esch, ...
Nature chemical biology 8 (5), 455-464, 2012
Kinetics for Drug Discovery: an industry-driven effort to target drug residence time
DA Schuetz, WEA de Witte, YC Wong, B Knasmueller, L Richter, DB Kokh, ...
Drug Discovery Today 22 (6), 896-911, 2017
The importance of a nitrogen atom in modulators of multidrug resistance
G Ecker, M Huber, D Schmid, P Chiba
Molecular pharmacology 56 (4), 791-796, 1999
Evidence-based approach to assess passive diffusion and carrier-mediated drug transport
L Di, P Artursson, A Avdeef, GF Ecker, B Faller, H Fischer, JB Houston, ...
Drug discovery today 17 (15-16), 905-912, 2012
P-glycoprotein substrate binding domains are located at the transmembrane domain/transmembrane domain interfaces: a combined photoaffinity labeling-protein homology modeling …
K Pleban, S Kopp, E Csaszar, M Peer, T Hrebicek, A Rizzi, GF Ecker, ...
Molecular pharmacology 67 (2), 365-374, 2005
The N terminus of monoamine transporters is a lever required for the action of amphetamines
S Sucic, S Dallinger, B Zdrazil, R Weissensteiner, TN Jørgensen, M Holy, ...
Journal of Biological Chemistry 285 (14), 10924-10938, 2010
Passive lipoidal diffusion and carrier-mediated cell uptake are both important mechanisms of membrane permeation in drug disposition
D Smith, P Artursson, A Avdeef, L Di, GF Ecker, B Faller, JB Houston, ...
Molecular pharmaceutics 11 (6), 1727-1738, 2014
Translation termination factor GSPT1 is a phenotypically relevant off-target of heterobifunctional phthalimide degraders
M Ishoey, S Chorn, N Singh, MG Jaeger, M Brand, J Paulk, S Bauer, ...
ACS Chemical Biology 13 (3), 553-560, 2018
Reversal of antifungal resistance mediated by ABC efflux pumps from Candida albicans functionally expressed in yeast
M Schuetzer-Muehlbauer, B Willinger, R Egner, G Ecker, K Kuchler
International journal of antimicrobial agents 22 (3), 291-300, 2003
Structural requirements for activity of propafenone-type modulators in P-glycoprotein-mediated multidrug resistance.
P Chiba, G Ecker, D Schmid, J Drach, B Tell, S Goldenberg, V Gekeler
Molecular Pharmacology 49 (6), 1122-1130, 1996
Insights into the structure, function, and ligand discovery of the large neutral amino acid transporter 1, LAT1
N Singh, GF Ecker
International journal of molecular sciences 19 (5), 1278, 2018
Aminorex, a metabolite of the cocaine adulterant levamisole, exerts amphetamine like actions at monoamine transporters
T Hofmaier, A Luf, A Seddik, T Stockner, M Holy, M Freissmuth, GF Ecker, ...
Neurochemistry international 73, 32-41, 2014
Structure–activity relationships, ligand efficiency, and lipophilic efficiency profiles of benzophenone-type inhibitors of the multidrug transporter P-glycoprotein
I Jabeen, K Pleban, U Rinner, P Chiba, GF Ecker
Journal of medicinal chemistry 55 (7), 3261-3273, 2012
Substituted 4-acylpyrazoles and 4-acylpyrazolones: synthesis and multidrug resistance-modulating activity
P Chiba, W Holzer, M Landau, G Bechmann, K Lorenz, B Plagens, ...
Journal of medicinal chemistry 41 (21), 4001-4011, 1998
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