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Ashley Canning
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EGCG binds intrinsically disordered N-terminal domain of p53 and disrupts p53-MDM2 interaction
J Zhao, A Blayney, X Liu, L Gandy, W Jin, L Yan, JH Ha, AJ Canning, ...
Nature communications 12 (1), 986, 2021
1592021
ALS-linked mutations affect UBQLN2 oligomerization and phase separation in a position-and amino acid-dependent manner
TP Dao, B Martyniak, AJ Canning, Y Lei, EG Colicino, MS Cosgrove, ...
Structure 27 (6), 937-951. e5, 2019
842019
Structure analysis suggests Ess1 isomerizes the carboxy-terminal domain of RNA polymerase II via a bivalent anchoring mechanism
KEW Namitz, T Zheng, AJ Canning, NL Alicea-Velazquez, CA Castañeda, ...
Communications Biology 4 (1), 398, 2021
92021
Kinetics of the multitasking high-affinity Win binding site of WDR5 in restricted and unrestricted conditions
A Imran, BS Moyer, AJ Canning, D Kalina, TM Duncan, KJ Moody, ...
Biochemical Journal 478 (11), 2145-2161, 2021
72021
Molecular determinants of the interaction between HSV-1 glycoprotein D and heparan sulfate
LA Gandy, AJ Canning, H Lou, K Xia, P He, G Su, T Cairns, J Liu, F Zhang, ...
Frontiers in Molecular Biosciences 9, 1043713, 2022
52022
Identification of proteins using four methods of matrix-assisted laser desorption ionization time-of-flight mass spectrometry
KG Bendinskas, AJ Canning, AE Smith
Journal of Chemical Education 96 (11), 2600-2605, 2019
42019
Parallel functional annotation of cancer-associated missense mutations in histone methyltransferases
AJ Canning, S Viggiano, ME Fernandez-Zapico, MS Cosgrove
Scientific reports 12 (1), 18487, 2022
22022
Hernia and hydrocele in boys
DA Canning, C Pavlock
Atlas of the Urologic Clinics of North America 12 (1), 1-13, 2004
12004
Parallel functional annotation of cancer-associated missense mutations in histone methyltransferases
M Cosgrove, A Canning, S Viggiano, M Fernandez-Zapico
2022
Exploring the kinetics of the Win-site of WDR5
A Imran, BS Moyer, A Canning, D Kalina, T Duncan, KJ Moody, A Wolfe, ...
Biophysical Journal 121 (3), 54a, 2022
2022
A Structure/Function Perspective of Mixed Lineage Leukemia 3 (MLL3) Histone Monomethyltransferase Complexes and Their Cancer-Associated Catalytic Abnormalities
AJ Canning
State University of New York, Upstate Medical University, 2022
2022
Sensing Mixed Lineage Leukemia Win Motif Peptide-WD Repeat Protein-5 Association with an Engineered Biosensor
LA Mayse, A Canning, A Imran, M Cosgrove, L Movileanu
Biophysical Journal 118 (3), 152a-153a, 2020
2020
Solution Structure Studies of Ess1 Interactions with the RNAPII CTD Suggest a Dual Binding Mechanism that Differs from that of Human Pin1
T Zheng, K Namitz, A Canning, N Alicea-Velazquez, CA Castaneda, ...
Biophysical Journal 118 (3), 531a, 2020
2020
Disease-Linked Mutations in UBQLN2 Proline-Rich Region Promote Phase Separation and Liquid-To-Solid Phase Transitions
CA Castaneda, TP Dao, B Martyniak, Y Lei, A Canning, E Colicino, ...
Biophysical Journal 116 (3), 348a, 2019
2019
Systematic Mutational Analysis of Mixed Lineage Leukemia 3 (MLL3) Histone Methyltransferase Active Site Suggests Single Phe/Tyr Switch Position to Regulate Product Specificity
A Canning, N Alicea‐Velazquez, M Cosgrove
The FASEB Journal 31, 755.4-755.4, 2017
2017
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