Marianne G Rots
Marianne G Rots
hoogleraar Moleculaire Epigenetica
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EpCAM in carcinogenesis: the good, the bad or the ugly
BTF van der Gun, LJ Melchers, MHJ Ruiters, LFMH de Leij, ...
Carcinogenesis 31 (11), 1913-1921, 2010
Expression of deoxycytidine kinase in leukaemic cells compared with solid tumour cell lines, liver metastases and normal liver
CL Van Der Wilt, JR Kroep, WJP Loves, MG Rots, CJ Van Groeningen, ...
European Journal of Cancer 39 (5), 691-697, 2003
Epigenetic reprogramming of cancer cells via targeted DNA methylation
AG Rivenbark, S Stolzenburg, AS Beltran, X Yuan, MG Rots, BD Strahl, ...
Epigenetics 7 (4), 350-360, 2012
Differential effects of NF-κB and p38 MAPK inhibitors and combinations thereof on TNF-α-and IL-1β-induced proinflammatory status of endothelial cells in vitro
JM Kułdo, J Westra, SA Ásgeirsdóttir, RJ Kok, K Oosterhuis, MG Rots, ...
American Journal of Physiology-Cell Physiology 289 (5), C1229-C1239, 2005
Different drug sensitivity profiles of acute myeloid and lymphoblastic leukemia and normal peripheral blood mononuclear cells in children with and without Down syndrome
CM Zwaan, GJL Kaspers, R Pieters, K Hählen, GE Janka-Schaub, ...
Blood, The Journal of the American Society of Hematology 99 (1), 245-251, 2002
A Novel Strategy to Modify Adenovirus Tropism and Enhance Transgene Delivery to Activated Vascular Endothelial Cells In Vitro and In Vivo
K Ogawara, MG Rots, RJ Kok, HE Moorlag, AM Van Loenen, DKF Meijer, ...
Human gene therapy 15 (5), 433-443, 2004
Genetic evidence of assortative mating in humans
MR Robinson, A Kleinman, M Graff, AAE Vinkhuyzen, D Couper, ...
Nature Human Behaviour 1 (1), 1-13, 2017
Epigenetic Editing : targeted rewriting of epigenetic marks to modulate expression of selected target genes
ML de Groote, PJ Verschure, MG Rots
Nucleic acids research 40 (21), 10596-10613, 2012
Role of folylpolyglutamate synthetase and folylpolyglutamate hydrolase in methotrexate accumulation and polyglutamylation in childhood leukemia
MG Rots, R Pieters, GJ Peters, P Noordhuis, CH Van Zantwijk, ...
Blood, The Journal of the American Society of Hematology 93 (5), 1677-1683, 1999
Targeted silencing of the oncogenic transcription factor SOX2 in breast cancer
S Stolzenburg, MG Rots, AS Beltran, AG Rivenbark, X Yuan, H Qian, ...
Nucleic acids research 40 (14), 6725-6740, 2012
Writing of H3K4Me3 overcomes epigenetic silencing in a sustained but context-dependent manner
D Cano-Rodriguez, RAF Gjaltema, LJ Jilderda, P Jellema, ...
Nature communications 7 (1), 1-11, 2016
Targeted methylation and gene silencing of VEGF-A in human cells by using a designed Dnmt3a–Dnmt3L single-chain fusion protein with increased DNA methylation activity
AN Siddique, S Nunna, A Rajavelu, Y Zhang, RZ Jurkowska, R Reinhardt, ...
Journal of molecular biology 425 (3), 479-491, 2013
Induced DNA demethylation by targeting Ten-Eleven Translocation 2 to the human ICAM-1 promoter
H Chen, HG Kazemier, ML de Groote, MHJ Ruiters, GL Xu, MG Rots
Nucleic acids research 42 (3), 1563-1574, 2014
Therapeutic modulation of endogenous gene function by agents with designed DNA‐sequence specificities
TG Uil, HJ Haisma, MG Rots
Nucleic acids research 31 (21), 6064-6078, 2003
Genome analyses of> 200,000 individuals identify 58 loci for chronic inflammation and highlight pathways that link inflammation and complex disorders
S Ligthart, A Vaez, U Võsa, MG Stathopoulou, PS De Vries, BP Prins, ...
The American Journal of Human Genetics 103 (5), 691-706, 2018
mRNA expression levels of methotrexate resistance-related proteins in childhood leukemia as determined by a standardized competitive template-based RT-PCR method
MG Rots, JC Willey, G Jansen, CH Van Zantwijk, P Noordhuis, JP DeMuth, ...
Leukemia 14 (12), 2166-2175, 2000
The timeline of epigenetic drug discovery: from reality to dreams
A Ganesan, PB Arimondo, MG Rots, C Jeronimo, M Berdasco
Clinical epigenetics 11 (1), 1-17, 2019
Protein transduction domains and their utility in gene therapy
AMJ Beerens, AFY Al Hadithy, MG Rots, HJ Haisma
Current gene therapy 3 (5), 486-494, 2003
A novel ex vivo model system for evaluation of conditionally replicative adenoviruses therapeutic efficacy and toxicity
TO Kirby, A Rivera, D Rein, M Wang, I Ulasov, M Breidenbach, M Kataram, ...
Clinical Cancer Research 10 (24), 8697-8703, 2004
Engineering zinc finger protein transcription factors: the therapeutic relevance of switching endogenous gene expression on or off at command
WM Gommans, HJ Haisma, MG Rots
Journal of molecular biology 354 (3), 507-519, 2005
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