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Stina Syvänen
Stina Syvänen
Professor, Public Health and Caring Sciences
Bestätigte E-Mail-Adresse bei pubcare.uu.se - Startseite
Titel
Zitiert von
Zitiert von
Jahr
On the rate and extent of drug delivery to the brain
M Hammarlund-Udenaes, M Fridén, S Syvänen, A Gupta
Pharmaceutical research 25, 1737-1750, 2008
5112008
Species differences in blood-brain barrier transport of three positron emission tomography radioligands with emphasis on P-glycoprotein transport
S Syvänen, Ö Lindhe, M Palner, BR Kornum, O Rahman, B Långström, ...
Drug metabolism and disposition 37 (3), 635-643, 2009
3732009
Antibody-based PET imaging of amyloid beta in mouse models of Alzheimer’s disease
D Sehlin, XT Fang, L Cato, G Antoni, L Lannfelt, S Syvänen
Nature communications 7 (1), 10759, 2016
1932016
Bivalent brain shuttle increases antibody uptake by monovalent binding to the transferrin receptor
G Hultqvist, S Syvänen, XT Fang, L Lannfelt, D Sehlin
Theranostics 7 (2), 308, 2017
1632017
Efficient and inexpensive transient expression of multispecific multivalent antibodies in Expi293 cells
XT Fang, D Sehlin, L Lannfelt, S Syvänen, G Hultqvist
Biological procedures online 19, 1-9, 2017
882017
Advances in PET imaging of P-glycoprotein function at the blood-brain barrier
S Syvänen, J Eriksson
ACS chemical neuroscience 4 (2), 225-237, 2013
882013
Advances in the development of new biomarkers for Alzheimer’s disease
TO Klyucherev, P Olszewski, AA Shalimova, VN Chubarev, VV Tarasov, ...
Translational neurodegeneration 11 (1), 25, 2022
872022
Specific uptake of an amyloid-β protofibril-binding antibody-tracer in AβPP transgenic mouse brain
K Magnusson, D Sehlin, S Syvänen, MM Svedberg, O Philipson, ...
Journal of Alzheimer's Disease 37 (1), 29-40, 2013
782013
Delineating amyloid plaque associated neuronal sphingolipids in transgenic Alzheimer’s disease mice (tgArcSwe) using MALDI imaging mass spectrometry
I Kaya, D Brinet, W Michno, S Syvänen, D Sehlin, H Zetterberg, ...
ACS chemical neuroscience 8 (2), 347-355, 2017
772017
Duration and degree of cyclosporin induced P-glycoprotein inhibition in the rat blood–brain barrier can be studied with PET
S Syvänen, G Blomquist, M Sprycha, AU Höglund, M Roman, O Eriksson, ...
Neuroimage 32 (3), 1134-1141, 2006
742006
Astroglial responses to amyloid-beta progression in a mouse model of Alzheimer’s disease
M Olsen, X Aguilar, D Sehlin, XT Fang, G Antoni, A Erlandsson, ...
Molecular Imaging and Biology 20, 605-614, 2018
722018
Pharmacokinetic consequences of active drug efflux at the blood–brain barrier
S Syvänen, R Xie, S Sahin, M Hammarlund-Udenaes
Pharmaceutical research 23, 705-717, 2006
722006
Pyroglutamation of amyloid-βx-42 (Aβx-42) followed by Aβ1–40 deposition underlies plaque polymorphism in progressing Alzheimer’s disease pathology
W Michno, S Nyström, P Wehrli, T Lashley, G Brinkmalm, L Guerard, ...
Journal of Biological Chemistry 294 (17), 6719-6732, 2019
652019
Engineered antibodies: new possibilities for brain PET?
D Sehlin, S Syvänen
European journal of nuclear medicine and molecular imaging 46 (13), 2848-2858, 2019
632019
High detection sensitivity with antibody-based PET radioligand for amyloid beta in brain
XT Fang, G Hultqvist, SR Meier, G Antoni, D Sehlin, S Syvänen
Neuroimage 184, 881-888, 2019
612019
Efficient clearance of Aβ protofibrils in AβPP-transgenic mice treated with a brain-penetrating bifunctional antibody
S Syvänen, G Hultqvist, T Gustavsson, A Gumucio, H Laudon, ...
Alzheimer's Research & Therapy 10, 1-10, 2018
582018
A bispecific Tribody PET radioligand for visualization of amyloid-beta protofibrils–a new concept for neuroimaging
S Syvänen, XT Fang, G Hultqvist, SR Meier, L Lannfelt, D Sehlin
Neuroimage 148, 55-63, 2017
582017
Pharmacokinetics, biodistribution and brain retention of a bispecific antibody-based PET radioligand for imaging of amyloid-β
D Sehlin, XT Fang, SR Meier, M Jansson, S Syvänen
Scientific Reports 7 (1), 17254, 2017
502017
Antibody-based in vivo PET imaging detects amyloid-β reduction in Alzheimer transgenic mice after BACE-1 inhibition
SR Meier, S Syvänen, G Hultqvist, XT Fang, S Roshanbin, L Lannfelt, ...
Journal of Nuclear Medicine 59 (12), 1885-1891, 2018
492018
Probing amyloid‐β pathology in transgenic Alzheimer's disease (tgArcSwe) mice using MALDI imaging mass spectrometry
L Carlred, W Michno, I Kaya, P Sjövall, S Syvänen, J Hanrieder
Journal of neurochemistry 138 (3), 469-478, 2016
482016
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