| Biological and chemical approaches to diseases of proteostasis deficiency ET Powers, RI Morimoto, A Dillin, JW Kelly, WE Balch Annual review of biochemistry 78, 959-991, 2009 | 1422 | 2009 |
| Tafamidis, a potent and selective transthyretin kinetic stabilizer that inhibits the amyloid cascade CE Bulawa, S Connelly, M DeVit, L Wang, C Weigel, JA Fleming, ... Proceedings of the National Academy of Sciences 109 (24), 9629-9634, 2012 | 720 | 2012 |
| Aβ induces astrocytic glutamate release, extrasynaptic NMDA receptor activation, and synaptic loss M Talantova, S Sanz-Blasco, X Zhang, P Xia, MW Akhtar, S Okamoto, ... Proceedings of the National Academy of Sciences 110 (27), E2518-E2527, 2013 | 632 | 2013 |
| Prevention of transthyretin amyloid disease by changing protein misfolding energetics P Hammarstrom, RL Wiseman, ET Powers, JW Kelly Science 299 (5607), 713-716, 2003 | 599 | 2003 |
| Amyloid-β forms fibrils by nucleated conformational conversion of oligomers J Lee, EK Culyba, ET Powers, JW Kelly Nature chemical biology 7 (9), 602-609, 2011 | 460 | 2011 |
| Targeting protein aggregation for the treatment of degenerative diseases YS Eisele, C Monteiro, C Fearns, SE Encalada, RL Wiseman, ET Powers, ... Nature reviews Drug discovery 14 (11), 759-780, 2015 | 417 | 2015 |
| Transthyretin aggregation under partially denaturing conditions is a downhill polymerization AR Hurshman, JT White, ET Powers, JW Kelly Biochemistry 43 (23), 7365-7381, 2004 | 412 | 2004 |
| Sequence-dependent denaturation energetics: a major determinant in amyloid disease diversity P Hammarström, X Jiang, AR Hurshman, ET Powers, JW Kelly Proceedings of the National Academy of Sciences 99 (suppl_4), 16427-16432, 2002 | 411 | 2002 |
| Elevated levels of oxidized cholesterol metabolites in Lewy body disease brains accelerate α-synuclein fibrilization DA Bosco, DM Fowler, Q Zhang, J Nieva, ET Powers, P Wentworth, ... Nature chemical biology 2 (5), 249-253, 2006 | 394 | 2006 |
| The transthyretin amyloidoses: from delineating the molecular mechanism of aggregation linked to pathology to a regulatory-agency-approved drug SM Johnson, S Connelly, C Fearns, ET Powers, JW Kelly Journal of molecular biology 421 (2-3), 185-203, 2012 | 365 | 2012 |
| Context-dependent contributions of backbone hydrogen bonding to β-sheet folding energetics S Deechongkit, H Nguyen, ET Powers, PE Dawson, M Gruebele, JW Kelly Nature 430 (6995), 101-105, 2004 | 321 | 2004 |
| Benzoxazoles as transthyretin amyloid fibril inhibitors: synthesis, evaluation, and mechanism of action H Razavi, SK Palaninathan, ET Powers, RL Wiseman, HE Purkey, ... Angewandte Chemie 115 (24), 2864-2867, 2003 | 284 | 2003 |
| Diversity in the origins of proteostasis networks—a driver for protein function in evolution ET Powers, WE Balch Nature reviews Molecular cell biology 14 (4), 237-248, 2013 | 259 | 2013 |
| The core trisaccharide of an N-linked glycoprotein intrinsically accelerates folding and enhances stability SR Hanson, EK Culyba, TL Hsu, CH Wong, JW Kelly, ET Powers Proceedings of the National Academy of Sciences 106 (9), 3131-3136, 2009 | 259 | 2009 |
| ALS mutants of human superoxide dismutase form fibrous aggregates via framework destabilization M DiDonato, L Craig, ME Huff, MM Thayer, RMF Cardoso, CJ Kassmann, ... Journal of molecular biology 332 (3), 601-615, 2003 | 258 | 2003 |
| Metabolite-initiated protein misfolding may trigger Alzheimer's disease Q Zhang, ET Powers, J Nieva, ME Huff, MA Dendle, J Bieschke, CG Glabe, ... Proceedings of the National Academy of Sciences 101 (14), 4752-4757, 2004 | 247 | 2004 |
| The kinetics of nucleated polymerizations at high concentrations: amyloid fibril formation near and above the “supercritical concentration” ET Powers, DL Powers Biophysical journal 91 (1), 122-132, 2006 | 243 | 2006 |
| “Inverse drug discovery” strategy to identify proteins that are targeted by latent electrophiles as exemplified by aryl fluorosulfates DE Mortenson, GJ Brighty, L Plate, G Bare, W Chen, S Li, H Wang, ... Journal of the American Chemical Society 140 (1), 200-210, 2018 | 230 | 2018 |
| Localized thermodynamic coupling between hydrogen bonding and microenvironment polarity substantially stabilizes proteins J Gao, DA Bosco, ET Powers, JW Kelly Nature structural & molecular biology 16 (7), 684-690, 2009 | 226 | 2009 |
| Arylfluorosulfates inactivate intracellular lipid binding protein (s) through chemoselective SuFEx reaction with a binding site Tyr residue W Chen, J Dong, L Plate, DE Mortenson, GJ Brighty, S Li, Y Liu, ... Journal of the American Chemical Society 138 (23), 7353-7364, 2016 | 223 | 2016 |
