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Benedict-Tilman Berger
Benedict-Tilman Berger
PostDoc Biochemistry, Goethe University Frankfurt
Bestätigte E-Mail-Adresse bei chemie.uni-frankfurt.de
Titel
Zitiert von
Zitiert von
Jahr
Quantitative, wide-spectrum kinase profiling in live cells for assessing the effect of cellular ATP on target engagement
JD Vasta, CR Corona, J Wilkinson, CA Zimprich, JR Hartnett, MR Ingold, ...
Cell chemical biology 25 (2), 206-214. e11, 2018
2082018
Binding kinetics survey of the drugged kinome
V Georgi, F Schiele, BT Berger, A Steffen, PA Marin Zapata, H Briem, ...
Journal of the American Chemical Society 140 (46), 15774-15782, 2018
612018
SGC-GAK-1: a chemical probe for cyclin G associated kinase (GAK)
CRM Asquith, BT Berger, J Wan, JM Bennett, SJ Capuzzi, DJ Crona, ...
Journal of medicinal chemistry 62 (5), 2830-2836, 2019
582019
Development, Optimization, and Structure–Activity Relationships of Covalent-Reversible JAK3 Inhibitors Based on a Tricyclic Imidazo[5,4-d]pyrrolo[2,3-b]pyridine …
M Forster, A Chaikuad, T Dimitrov, E Döring, J Holstein, BT Berger, ...
Journal of Medicinal Chemistry 61 (12), 5350-5366, 2018
522018
Furo[3,2‐b]pyridine: A Privileged Scaffold for Highly Selective Kinase Inhibitors and Effective Modulators of the Hedgehog Pathway
V Němec, M Hylsová, L Maier, J Flegel, S Sievers, S Ziegler, M Schröder, ...
Angewandte Chemie International Edition 58 (4), 1062-1066, 2019
482019
Structure-kinetic relationship reveals the mechanism of selectivity of FAK inhibitors over PYK2
BT Berger, M Amaral, DB Kokh, A Nunes-Alves, D Musil, T Heinrich, ...
Cell Chemical Biology 28 (5), 686-698. e7, 2021
422021
Quantifying target occupancy of small molecules within living cells
MB Robers, R Friedman-Ohana, KVM Huber, L Kilpatrick, JD Vasta, ...
Annual review of biochemistry 89, 557-581, 2020
392020
Mutation in Abl kinase with altered drug-binding kinetics indicates a novel mechanism of imatinib resistance
A Lyczek, BT Berger, AM Rangwala, YT Paung, J Tom, H Philipose, J Guo, ...
Proceedings of the National Academy of Sciences 118 (46), e2111451118, 2021
372021
Characterization of a dual BET/HDAC inhibitor for treatment of pancreatic ductal adenocarcinoma
X Zhang, T Zegar, T Weiser, FH Hamdan, BT Berger, R Lucas, ...
International Journal of Cancer 147 (10), 2847-2861, 2020
352020
Identification of molecular targets for the targeted treatment of gastric cancer using dasatinib
RC Montenegro, A Howarth, A Ceroni, V Fedele, B Farran, FP Mesquita, ...
Oncotarget 11 (5), 535, 2020
302020
Controlling the covalent reactivity of a kinase inhibitor with light
M Reynders, A Chaikuad, BT Berger, K Bauer, P Koch, S Laufer, S Knapp, ...
Angewandte Chemie International Edition 60 (37), 20178-20183, 2021
282021
Optimization of pyrazolo [1, 5-a] pyrimidines lead to the identification of a highly selective casein kinase 2 inhibitor
A Krämer, CG Kurz, BT Berger, IE Celik, A Tjaden, FA Greco, S Knapp, ...
European Journal of Medicinal Chemistry 208, 112770, 2020
272020
NVP‐BHG712: Effects of Regioisomers on the Affinity and Selectivity toward the EPHrin Family
A Tröster, S Heinzlmeir, BT Berger, SL Gande, K Saxena, S Sreeramulu, ...
ChemMedChem 13 (16), 1629-1633, 2018
262018
Structure-based design of selective salt-inducible kinase inhibitors
R Tesch, M Rak, M Raab, LM Berger, T Kronenberger, AC Joerger, ...
Journal of Medicinal Chemistry 64 (12), 8142-8160, 2021
252021
CDK11 regulates pre-mRNA splicing by phosphorylation of SF3B1
M Hluchý, P Gajdušková, I Ruiz de los Mozos, M Rájecký, M Kluge, ...
Nature 609 (7928), 829-834, 2022
232022
Fast iterative synthetic approach toward identification of novel highly selective p38 MAP kinase inhibitors
S Röhm, BT Berger, M Schröder, A Chaikuad, R Winkel, KFW Hekking, ...
Journal of medicinal chemistry 62 (23), 10757-10782, 2019
232019
Design of a “two-in-one” mutant-selective epidermal growth factor receptor inhibitor that spans the orthosteric and allosteric sites
F Wittlinger, DE Heppner, C To, M Günther, BH Shin, JK Rana, ...
Journal of medicinal chemistry 65 (2), 1370-1383, 2021
182021
Highly selective inhibitors of protein kinases CLK and HIPK with the furo [3, 2-b] pyridine core
V Němec, L Maier, BT Berger, A Chaikuad, S Drapela, K Souček, S Knapp, ...
European Journal of Medicinal Chemistry 215, 113299, 2021
152021
Bioisosteric Replacement of Arylamide-Linked Spine Residues with N-Acylhydrazones and Selenophenes as a Design Strategy to Novel Dibenzosuberone …
JGB Pedreira, P Nahidino, M Kudolo, T Pantsar, BT Berger, M Forster, ...
Journal of Medicinal Chemistry 63 (13), 7347-7354, 2020
152020
A highly selective chemical probe for activin receptor-like kinases ALK4 and ALK5
T Hanke, JF Wong, BT Berger, I Abdi, LM Berger, R Tesch, C Tredup, ...
ACS Chemical Biology 15 (4), 862-870, 2020
142020
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