Roy Ummels
Roy Ummels
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General secretion signal for the mycobacterial type VII secretion pathway
MH Daleke, R Ummels, P Bawono, J Heringa, ...
Proceedings of the National Academy of Sciences 109 (28), 11342-11347, 2012
Composition of the type VII secretion system membrane complex
ENG Houben, J Bestebroer, R Ummels, L Wilson, SR Piersma, ...
Molecular microbiology 86 (2), 472-484, 2012
Conserved Pro-Glu (PE) and Pro-Pro-Glu (PPE) protein domains target LipY lipases of pathogenic mycobacteria to the cell surface via the ESX-5 pathway
MH Daleke, A Cascioferro, K De Punder, R Ummels, AM Abdallah, ...
Journal of Biological Chemistry 286 (21), 19024-19034, 2011
Identification of mycobacterial α-glucan as a novel ligand for DC-SIGN: involvement of mycobacterial capsular polysaccharides in host immune modulation
J Geurtsen, S Chedammi, J Mesters, M Cot, NN Driessen, T Sambou, ...
The journal of immunology 183 (8), 5221-5231, 2009
The mannose cap of mycobacterial lipoarabinomannan does not dominate the Mycobacterium–host interaction
BJ Appelmelk, J Den Dunnen, NN Driessen, R Ummels, M Pak, J Nigou, ...
Cellular microbiology 10 (4), 930-944, 2008
Essential role of the ESX-5 secretion system in outer membrane permeability of pathogenic mycobacteria
LS Ates, R Ummels, S Commandeur, R van der Weerd, M Sparrius, ...
PLoS Genet 11 (5), e1005190, 2015
Role of phosphatidylinositol mannosides in the interaction between mycobacteria and DC-SIGN
NN Driessen, R Ummels, JJ Maaskant, SS Gurcha, GS Besra, GD Ainge, ...
Infection and immunity 77 (10), 4538-4547, 2009
Structure of the mycobacterial ESX-5 type VII secretion system membrane complex by single-particle analysis
KSH Beckham, L Ciccarelli, CM Bunduc, HDT Mertens, R Ummels, ...
Nature microbiology 2 (6), 1-7, 2017
SecB-like chaperone controls a toxin–antitoxin stress-responsive system in Mycobacterium tuberculosis
P Bordes, AM Cirinesi, R Ummels, A Sala, S Sakr, W Bitter, P Genevaux
Proceedings of the National Academy of Sciences 108 (20), 8438-8443, 2011
Specific chaperones for the type VII protein secretion pathway
MH Daleke, AD Van Der Woude, AHA Parret, R Ummels, AM de Groot, ...
Journal of Biological Chemistry 287 (38), 31939-31947, 2012
Mutations in ppe38 block PE_PGRS secretion and increase virulence of Mycobacterium tuberculosis
LS Ates, A Dippenaar, R Ummels, SR Piersma, AD van der Woude, ...
Nature microbiology 3 (2), 181-188, 2018
Structure of the Mycobacterium tuberculosis type VII secretion system chaperone EspG5 in complex with PE25–PPE41 dimer
N Korotkova, D Freire, TH Phan, R Ummels, CC Creekmore, TJ Evans, ...
Molecular microbiology 94 (2), 367-382, 2014
Genomic expression catalogue of a global collection of BCG vaccine strains show evidence for highly diverged metabolic and cell-wall adaptations
AM Abdallah, GA Hill-Cawthorne, TD Otto, F Coll, JA Guerra-Assunção, ...
Scientific reports 5 (1), 1-15, 2015
Genome-wide transposon mutagenesis indicates that Mycobacterium marinum customizes its virulence mechanisms for survival and replication in different hosts
EM Weerdenburg, AM Abdallah, F Rangkuti, M Abd El Ghany, TD Otto, ...
Infection and immunity 83 (5), 1778-1788, 2015
Identification of a novel conjugative plasmid in mycobacteria that requires both type IV and type VII secretion
R Ummels, AM Abdallah, V Kuiper, A Aâjoud, M Sparrius, R Naeem, ...
MBio 5 (5), e01744-14, 2014
Analysis of SecA2‐dependent substrates in Mycobacterium marinum identifies protein kinase G (PknG) as a virulence effector
AD van der Woude, EJM Stoop, M Stiess, S Wang, R Ummels, ...
Cellular microbiology 16 (2), 280-295, 2014
Mycosins are required for the stabilization of the ESX-1 and ESX-5 type VII secretion membrane complexes
VJC van Winden, R Ummels, SR Piersma, CR Jiménez, KV Korotkov, ...
MBio 7 (5), e01471-16, 2016
Lipoarabinomannan mannose caps do not affect mycobacterial virulence or the induction of protective immunity in experimental animal models of infection and have minimal impact …
A Afonso‐Barroso, SO Clark, A Williams, GT Rosa, C Nóbrega, ...
Cellular microbiology 15 (4), 660-674, 2013
The anti-mycobacterial activity of the cytochrome bcc inhibitor Q203 can be enhanced by small-molecule inhibition of cytochrome bd
P Lu, AH Asseri, M Kremer, J Maaskant, R Ummels, H Lill, D Bald
Scientific reports 8 (1), 1-7, 2018
Identification of a substrate domain that determines system specificity in mycobacterial type VII secretion systems
TH Phan, R Ummels, W Bitter, ENG Houben
Scientific reports 7 (1), 1-9, 2017
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