Design of a peptide-based vector, PepFect6, for efficient delivery of siRNA in cell culture and systemically in vivo S EL Andaloussi, T Lehto, I Mäger, K Rosenthal-Aizman, II Oprea, ... Nucleic acids research 39 (9), 3972-3987, 2011 | 327 | 2011 |
PepFect 14, a novel cell-penetrating peptide for oligonucleotide delivery in solution and as solid formulation K Ezzat, S EL Andaloussi, EM Zaghloul, T Lehto, S Lindberg, P Moreno, ... Nucleic acids research 39 (12), 5284-5298, 2011 | 288 | 2011 |
A peptide-based vector for efficient gene transfer in vitro and in vivo T Lehto, OE Simonson, I Mäger, K Ezzat, H Sork, DM Copolovici, JR Viola, ... Molecular Therapy 19 (8), 1457-1467, 2011 | 138 | 2011 |
THERAPEUTIC ANTISENSE OLIGONUCLEOTIDES AGAINST CANCER: HURDLING TO THE CLINIC PMD Moreno, AP Pêgo Chemical Engineering 2, 87, 2014 | 135 | 2014 |
Splice-correcting oligonucleotides restore BTK function in X-linked agammaglobulinemia model B Bestas, PMD Moreno, KEM Blomberg, DK Mohammad, AF Saleh, ... The Journal of clinical investigation 124 (9), 4067-4081, 2014 | 75 | 2014 |
Optimizing anti-gene oligonucleotide ‘Zorro-LNA’for improved strand invasion into duplex DNA EM Zaghloul, AS Madsen, PMD Moreno, II Oprea, S El-Andaloussi, ... Nucleic acids research 39 (3), 1142-1154, 2011 | 50 | 2011 |
A synthetic snRNA m3G-CAP enhances nuclear delivery of exogenous proteins and nucleic acids PMD Moreno, M Wenska, KE Lundin, Ö Wrange, R Strömberg, CIE Smith Nucleic acids research 37 (6), 1925-1935, 2009 | 42 | 2009 |
2.13 Chitosan MA Barbosa, IC Gonçalves, PMD Moreno, RM Gonçalves, SG Santos, ... Elsevier, 2017 | 40 | 2017 |
Development of bis-locked nucleic acid (bisLNA) oligonucleotides for efficient invasion of supercoiled duplex DNA P Moreno, S Geny, YV Pabon, H Bergquist, EM Zaghloul, CSJ Rocha, ... Nucleic acids research 41 (5), 3257-3273, 2013 | 40 | 2013 |
Translating chitosan to clinical delivery of nucleic acid-based drugs CP Gomes, CDF Lopes, PMD Moreno, A Varela-Moreira, MJ Alonso, ... MRS bulletin 39 (1), 60-70, 2014 | 37 | 2014 |
Next-generation bis-locked nucleic acids with stacking linker and 2′-glycylamino-LNA show enhanced DNA invasion into supercoiled duplexes S Geny, P Moreno, T Krzywkowski, O Gissberg, NK Andersen, AJ Isse, ... Nucleic acids research 44 (5), 2007-2019, 2016 | 32 | 2016 |
Increased stability and specificity through combined hybridization of peptide nucleic acid (PNA) and locked nucleic acid (LNA) to supercoiled plasmids for PNA-anchored “Bioplex … KE Lundin, M Hasan, PM Moreno, E Törnquist, I Oprea, MG Svahn, ... Biomolecular engineering 22 (5-6), 185-192, 2005 | 32 | 2005 |
Biodegradable PEG–dendritic block copolymers: synthesis and biofunctionality assessment as vectors of siRNA V Leiro, JP Garcia, PMD Moreno, AP Spencer, M Fernandez-Villamarin, ... Journal of Materials Chemistry B 5 (25), 4901-4917, 2017 | 31 | 2017 |
Functionalized chitosan derivatives as nonviral vectors: physicochemical properties of acylated N, N, N-trimethyl chitosan/oligonucleotide nanopolyplexes JCC Santos, PMD Moreno, AAP Mansur, V Leiro, HS Mansur, AP Pêgo Soft matter 11 (41), 8113-8125, 2015 | 31 | 2015 |
Nanotechnology approaches for gene transfer KE Lundin, OE Simonson, PMD Moreno, EM Zaghloul, II Oprea, ... Genetica 137 (1), 47-56, 2009 | 27 | 2009 |
CTG repeat-targeting oligonucleotides for down-regulating Huntingtin expression EM Zaghloul, O Gissberg, P Moreno, L Siggens, M Hällbrink, ... Nucleic acids research 45 (9), 5153-5169, 2017 | 23 | 2017 |
Fatty acid–spermine conjugates as DNA carriers for nonviral in vivo gene delivery JR Viola, H Leijonmarck, OE Simonson, II Oprea, R Frithiof, P Purhonen, ... Gene therapy 16 (12), 1429-1440, 2009 | 23 | 2009 |
Nuclease resistant oligonucleotides with cell penetrating properties S Milton, D Honcharenko, CSJ Rocha, PMD Moreno, CIE Smith, ... Chemical Communications 51 (19), 4044-4047, 2015 | 22 | 2015 |
RNA therapeutics inactivate PCSK9 by inducing a unique intracellular retention form CSJ Rocha, OPB Wiklander, L Larsson, PMD Moreno, P Parini, ... Journal of molecular and cellular cardiology 82, 186-193, 2015 | 21 | 2015 |
A high-throughput bioimaging study to assess the impact of chitosan-based nanoparticle degradation on DNA delivery performance CP Gomes, A Varela-Moreira, V Leiro, CDF Lopes, PMD Moreno, ... Acta Biomaterialia 46, 129-140, 2016 | 17 | 2016 |