| Highly efficient therapeutic gene editing of human hematopoietic stem cells Y Wu, J Zeng, BP Roscoe, P Liu, Q Yao, CR Lazzarotto, K Clement, ... Nature medicine 25 (5), 776-783, 2019 | 437 | 2019 |
| Genetic inactivation of CD33 in hematopoietic stem cells to enable CAR T cell immunotherapy for acute myeloid leukemia MY Kim, KR Yu, SS Kenderian, M Ruella, S Chen, TH Shin, AA Aljanahi, ... Cell 173 (6), 1439-1453. e19, 2018 | 402 | 2018 |
| Base editing of haematopoietic stem cells rescues sickle cell disease in mice GA Newby, JS Yen, KJ Woodard, T Mayuranathan, CR Lazzarotto, Y Li, ... Nature 595 (7866), 295-302, 2021 | 235 | 2021 |
| CHANGE-seq reveals genetic and epigenetic effects on CRISPR–Cas9 genome-wide activity CR Lazzarotto, NL Malinin, Y Li, R Zhang, Y Yang, GH Lee, E Cowley, ... Nature biotechnology 38 (11), 1317-1327, 2020 | 173 | 2020 |
| Deleting DNMT3A in CAR T cells prevents exhaustion and enhances antitumor activity B Prinzing, CC Zebley, CT Petersen, Y Fan, AA Anido, Z Yi, P Nguyen, ... Science translational medicine 13 (620), eabh0272, 2021 | 147 | 2021 |
| Genome editing of HBG1 and HBG2 to induce fetal hemoglobin JY Métais, PA Doerfler, T Mayuranathan, DE Bauer, SC Fowler, MM Hsieh, ... Blood advances 3 (21), 3379-3392, 2019 | 138 | 2019 |
| The transgenic animal platform for biopharmaceutical production LR Bertolini, H Meade, CR Lazzarotto, LT Martins, KC Tavares, ... Transgenic research 25, 329-343, 2016 | 110 | 2016 |
| Defining CRISPR–Cas9 genome-wide nuclease activities with CIRCLE-seq CR Lazzarotto, NT Nguyen, X Tang, J Malagon-Lopez, JA Guo, MJ Aryee, ... Nature protocols 13 (11), 2615-2642, 2018 | 83 | 2018 |
| Prime editing in mice reveals the essentiality of a single base in driving tissue-specific gene expression P Gao, Q Lyu, AR Ghanam, CR Lazzarotto, GA Newby, W Zhang, M Choi, ... Genome biology 22, 1-21, 2021 | 73 | 2021 |
| BCL11A enhancer–edited hematopoietic stem cells persist in rhesus monkeys without toxicity S Demirci, J Zeng, Y Wu, N Uchida, AH Shen, D Pellin, J Gamer, ... The Journal of clinical investigation 130 (12), 6677-6687, 2020 | 56 | 2020 |
| Enhanced homology-directed repair for highly efficient gene editing in hematopoietic stem/progenitor cells SS De Ravin, J Brault, RJ Meis, S Liu, L Li, M Pavel-Dinu, CR Lazzarotto, ... Blood, The Journal of the American Society of Hematology 137 (19), 2598-2608, 2021 | 52 | 2021 |
| Defining genome-wide CRISPR–Cas genome-editing nuclease activity with GUIDE-seq NL Malinin, GH Lee, CR Lazzarotto, Y Li, Z Zheng, NT Nguyen, M Liebers, ... Nature protocols 16 (12), 5592-5615, 2021 | 35 | 2021 |
| In vivo engineered B cells secrete high titers of broadly neutralizing anti-HIV antibodies in mice AD Nahmad, CR Lazzarotto, N Zelikson, T Kustin, M Tenuta, D Huang, ... Nature biotechnology 40 (8), 1241-1249, 2022 | 34 | 2022 |
| Production and characterization of virus-free, CRISPR-CAR T cells capable of inducing solid tumor regression KP Mueller, NJ Piscopo, MH Forsberg, LA Saraspe, A Das, B Russell, ... Journal for immunotherapy of cancer 10 (9), 2022 | 27 | 2022 |
| Alanyl-glutamine attenuates 5-fluorouracil-induced intestinal mucositis in apolipoprotein E-deficient mice CV Araújo, CR Lazzarotto, CC Aquino, IL Figueiredo, TB Costa, ... Brazilian Journal of Medical and Biological Research 48, 493-501, 2015 | 27 | 2015 |
| CRISPR-targeted MAGT1 insertion restores XMEN patient hematopoietic stem cells and lymphocytes J Brault, T Liu, E Bello, S Liu, CL Sweeney, RJ Meis, S Koontz, C Corsino, ... Blood, The Journal of the American Society of Hematology 138 (26), 2768-2780, 2021 | 26 | 2021 |
| Prediction and validation of hematopoietic stem and progenitor cell off-target editing in transplanted rhesus macaques AA AlJanahi, CR Lazzarotto, S Chen, TH Shin, S Cordes, X Fan, I Jabara, ... Molecular Therapy 30 (1), 209-222, 2022 | 20 | 2022 |
| Potent and uniform fetal hemoglobin induction via base editing T Mayuranathan, GA Newby, R Feng, Y Yao, KD Mayberry, CR Lazzarotto, ... Nature genetics 55 (7), 1210-1220, 2023 | 18 | 2023 |
| Efficient correction of a deleterious point mutation in primary horse fibroblasts with CRISPR-Cas9 C Pinzon-Arteaga, MD Snyder, CR Lazzarotto, NF Moreno, R Juras, ... Scientific Reports 10 (1), 7411, 2020 | 17 | 2020 |
| A fast and simple method for the polymerase chain reaction-based sexing of livestock embryos KCS Tavares, IS Carneiro, DB Rios, C Feltrin, AKC Ribeiro, ... Genet Mol Res 15 (1), 2016 | 17 | 2016 |
