Elisabeth Nyakatura
Elisabeth Nyakatura
Associate Director, Antibody Engineering
Verified email at tritdi.org
Cited by
Cited by
Fluorinated amino acids: compatibility with native protein structures and effects on protein–protein interactions
M Salwiczek, EK Nyakatura, UIM Gerling, S Ye, B Koksch
Chemical Society Reviews 41 (6), 2135-2171, 2012
Antibodies from a human survivor define sites of vulnerability for broad protection against ebolaviruses
AZ Wec, AS Herbert, CD Murin, EK Nyakatura, DM Abelson, JM Fels, ...
Cell 169 (5), 878-890. e15, 2017
A “Trojan horse” bispecific-antibody strategy for broad protection against ebolaviruses
AZ Wec, EK Nyakatura, AS Herbert, KA Howell, FW Holtsberg, RR Bakken, ...
Science 354 (6310), 350-354, 2016
Pan-ebolavirus and pan-filovirus mouse monoclonal antibodies: protection against Ebola and Sudan viruses
FW Holtsberg, S Shulenin, H Vu, KA Howell, SJ Patel, B Gunn, M Karim, ...
Journal of virology 90 (1), 266-278, 2016
Gyrase B inhibitor impairs HIV-1 replication by targeting Hsp90 and the capsid protein
L Vozzolo, B Loh, PJ Gane, M Tribak, L Zhou, I Anderson, E Nyakatura, ...
Journal of Biological Chemistry 285 (50), 39314-39328, 2010
Antibody treatment of Ebola and Sudan virus infection via a uniquely exposed epitope within the glycoprotein receptor-binding site
KA Howell, X Qiu, JM Brannan, C Bryan, E Davidson, FW Holtsberg, ...
Cell reports 15 (7), 1514-1526, 2016
Position‐Dependent Effects of Fluorinated Amino Acids on the Hydrophobic Core Formation of a Heterodimeric Coiled Coil
M Salwiczek, S Samsonov, T Vagt, E Nyakatura, E Fleige, J Numata, ...
Chemistry–A European Journal 15 (31), 7628-7636, 2009
Chemical and structural aspects of Ebola virus entry inhibitors
EK Nyakatura, JC Frei, JR Lai
ACS infectious diseases 1 (1), 42-52, 2015
Towards identifying preferred interaction partners of fluorinated amino acids within the hydrophobic environment of a dimeric coiled coil peptide
T Vagt, E Nyakatura, M Salwiczek, C Jäckel, B Koksch
Organic & biomolecular chemistry 8 (6), 1382-1386, 2010
Protocadherin-1 is essential for cell entry by New World hantaviruses
RK Jangra, AS Herbert, R Li, LT Jae, LM Kleinfelter, MM Slough, ...
Nature 563 (7732), 559-563, 2018
Accommodating fluorinated amino acids in a helical peptide environment
EK Nyakatura, O Reimann, T Vagt, M Salwiczek, B Koksch
RSC advances 3 (18), 6319-6322, 2013
Bispecific antibody affords complete post-exposure protection of mice from both Ebola (Zaire) and Sudan viruses
JC Frei, EK Nyakatura, SE Zak, RR Bakken, K Chandran, JM Dye, JR Lai
Scientific reports 6, 19193, 2016
Effects of single substitutions with hexafluoroleucine and trifluorovaline on the hydrophobic core formation of a heterodimeric coiled coil
S Huhmann, EK Nyakatura, H Erdbrink, UIM Gerling, C Czekelius, ...
Journal of Fluorine Chemistry 175, 32-35, 2015
Synthesis of enantiomerically pure (2S, 3S)-5, 5, 5-trifluoroisoleucine and (2R, 3S)-5, 5, 5-trifluoro-allo-isoleucine
H Erdbrink, EK Nyakatura, S Huhmann, UIM Gerling, D Lentz, B Koksch, ...
Beilstein journal of organic chemistry 9 (1), 2009-2014, 2013
An Unusual Interstrand H-Bond Stabilizes The Heteroassembly Of Helical αβγ-Chimeras with Natural Peptides
EK Nyakatura, R Rezaei Araghi, J Mortier, S Wieczorek, C Baldauf, ...
ACS Chemical Biology 9 (3), 613-616, 2014
Bispecific antibodies for viral immunotherapy
EK Nyakatura, AY Soare, JR Lai
Human vaccines & immunotherapeutics 13 (4), 836-842, 2017
β-and γ-Amino Acids at α-Helical Interfaces: Toward the Formation of Highly Stable Foldameric Coiled Coils
EK Nyakatura, J Mortier, VS Radtke, S Wieczorek, R Rezaei Araghi, ...
ACS Medicinal Chemistry Letters 5 (12), 1300-1303, 2014
Design and evaluation of bi-and trispecific antibodies targeting multiple filovirus glycoproteins
EK Nyakatura, SE Zak, AZ Wec, D Hofmann, S Shulenin, RR Bakken, ...
Journal of Biological Chemistry 293 (16), 6201-6211, 2018
Human monoclonal antibodies against chikungunya virus target multiple distinct epitopes in the E1 and E2 glycoproteins
JA Quiroz, RJ Malonis, LB Thackray, CA Cohen, J Pallesen, RK Jangra, ...
PLoS pathogens 15 (11), e1008061, 2019
Antibody Treatment of Ebola and Sudan Virus Infection via a Uniquely Exposed Epitope within the Glycoprotein Receptor-Binding Site. Cell Rep. 2016; 15: 1514–1526
KA Howell, X Qiu, JM Brannan, C Bryan, E Davidson, FW Holtsberg, ...
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