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Hepatitis C virus targets the interferon-α JAK/STAT pathway by promoting proteasomal degradation in immune cells and hepatocytes NJ Stevenson, NM Bourke, EJ Ryan, M Binder, L Fanning, JA Johnston, ... FEBS letters 587 (10), 1571-1578, 2013 | 62 | 2013 |
Ribavirin enhances IFN-α signalling and MxA expression: a novel immune modulation mechanism during treatment of HCV NJ Stevenson, AG Murphy, NM Bourke, CA Keogh, JE Hegarty, ... PloS one 6 (11), e27866, 2011 | 61 | 2011 |
A novel anti-viral role for STAT3 in IFN-α signalling responses R Mahony, S Gargan, KL Roberts, N Bourke, SE Keating, AG Bowie, ... Cellular and Molecular Life Sciences 74, 1755-1764, 2017 | 48 | 2017 |
Longitudinal analysis of COVID-19 patients shows age-associated T cell changes independent of ongoing ill-health L Townsend, AH Dyer, A Naughton, R Kiersey, D Holden, M Gardiner, ... Frontiers in immunology 12, 676932, 2021 | 46 | 2021 |
Epigenetic clocks and allostatic load reveal potential sex-specific drivers of biological aging C McCrory, G Fiorito, S McLoughlin, S Polidoro, CN Cheallaigh, N Bourke, ... The Journals of Gerontology: Series A 75 (3), 495-503, 2020 | 46 | 2020 |
Properties and functions of the novel type I interferon epsilon ZRC Marks, N Campbell, NA deWeerd, SS Lim, LJ Gearing, NM Bourke, ... Seminars in Immunology 43, 101328, 2019 | 35 | 2019 |
Defective activation and regulation of type I interferon immunity is associated with increasing COVID-19 severity N Smith, C Possémé, V Bondet, J Sugrue, L Townsend, B Charbit, ... Nature Communications 13 (1), 7254, 2022 | 34 | 2022 |
Investigating the relationship between vitamin D and persistent symptoms following SARS-CoV-2 infection L Townsend, AH Dyer, P McCluskey, K O’Brien, J Dowds, E Laird, ... Nutrients 13 (7), 2430, 2021 | 32 | 2021 |
A comparative analysis of the status anxiety hypothesis of socio-economic inequalities in health based on 18,349 individuals in four countries and five cohort studies R Layte, C McCrory, CN Cheallaigh, N Bourke, M Kivimaki, AI Ribeiro, ... Scientific reports 9 (1), 796, 2019 | 32 | 2019 |
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A hot spot on interferon α/β receptor subunit 1 (IFNAR1) underpins its interaction with interferon-β and dictates signaling NA de Weerd, AY Matthews, PR Pattie, NM Bourke, SS Lim, JP Vivian, ... Journal of Biological Chemistry 292 (18), 7554-7565, 2017 | 26 | 2017 |
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