| Incorporation of pseudouridine into mRNA yields superior nonimmunogenic vector with increased translational capacity and biological stability K Karikó, H Muramatsu, FA Welsh, J Ludwig, H Kato, S Akira, ... Molecular therapy 16 (11), 1833-1840, 2008 | 1960 | 2008 |
| cGAS produces a 2′-5′-linked cyclic dinucleotide second messenger that activates STING A Ablasser, M Goldeck, T Cavlar, T Deimling, G Witte, I Röhl, KP Hopfner, ... Nature 498 (7454), 380-384, 2013 | 1615 | 2013 |
| Generating the optimal mRNA for therapy: HPLC purification eliminates immune activation and improves translation of nucleoside-modified, protein-encoding mRNA K Karikó, H Muramatsu, J Ludwig, D Weissman Nucleic acids research 39 (21), e142-e142, 2011 | 1004 | 2011 |
| Recognition of 5′ triphosphate by RIG-I helicase requires short blunt double-stranded RNA as contained in panhandle of negative-strand virus M Schlee, A Roth, V Hornung, CA Hagmann, V Wimmenauer, W Barchet, ... Immunity 31 (1), 25-34, 2009 | 970 | 2009 |
| Antiviral immunity via RIG-I-mediated recognition of RNA bearing 5′-diphosphates D Goubau, M Schlee, S Deddouche, AJ Pruijssers, T Zillinger, M Goldeck, ... Nature 514 (7522), 372-375, 2014 | 651 | 2014 |
| Identification of microRNAs and other small regulatory RNAs using cDNA library sequencing M Hafner, P Landgraf, J Ludwig, A Rice, T Ojo, C Lin, D Holoch, C Lim, ... Methods 44 (1), 3-12, 2008 | 588 | 2008 |
| Rapid and efficient synthesis of nucleoside 5'-0-(1-thiotriphosphates), 5'-triphosphates and 2', 3'-cyclophosphorothioates using 2-chloro-4H-1, 3, 2-benzodioxaphosphorin-4-one J Ludwig, F Eckstein The Journal of Organic Chemistry 54 (3), 631-635, 1989 | 576 | 1989 |
| RNA-ligase-dependent biases in miRNA representation in deep-sequenced small RNA cDNA libraries M Hafner, N Renwick, M Brown, A Mihailović, D Holoch, C Lin, JTG Pena, ... Rna 17 (9), 1697-1712, 2011 | 385 | 2011 |
| A new route to nucleoside 5′-triphosphates J Ludwig Acta Biochim. Biophys. Acad. Sci. Hung 16 ((3-4),), 131-133, 1981 | 385 | 1981 |
| miRNA in situ hybridization in formaldehyde and EDC–fixed tissues JTG Pena, C Sohn-Lee, SH Rouhanifard, J Ludwig, M Hafner, ... Nature methods 6 (2), 139-141, 2009 | 324 | 2009 |
| A conserved histidine in the RNA sensor RIG-I controls immune tolerance to N1-2′ O-methylated self RNA C Schuberth-Wagner, J Ludwig, AK Bruder, AM Herzner, T Zillinger, ... Immunity 43 (1), 41-51, 2015 | 308 | 2015 |
| Structural and functional insights into 5′-ppp RNA pattern recognition by the innate immune receptor RIG-I Y Wang, J Ludwig, C Schuberth, M Goldeck, M Schlee, H Li, S Juranek, ... Nature structural & molecular biology 17 (7), 781-787, 2010 | 287 | 2010 |
| Sequence-specific activation of the DNA sensor cGAS by Y-form DNA structures as found in primary HIV-1 cDNA AM Herzner, CA Hagmann, M Goldeck, S Wolter, K Kübler, S Wittmann, ... Nature immunology 16 (10), 1025-1033, 2015 | 266 | 2015 |
| Oligonucleotide duplexes containing 2′-amino-2′-deoxycytidines: thermal stability and chemical reactivity H Aurup, T Tuschl, F Benseler, J Ludwig, F Eckstein Nucleic acids research 22 (1), 20-24, 1994 | 174 | 1994 |
| Synthesis of nucleoside 5'-O-(1, 3-dithiotriphosphates) and 5'-O-(1, 1-dithiotriphosphates) J Ludwig, F Eckstein The Journal of Organic Chemistry 56 (5), 1777-1783, 1991 | 66 | 1991 |
| Hammerhead-like molecules containing non-nucleoside linkers are active RNA catalysts F Benseler, DJ Fu, J Ludwig, LW McLaughlin Journal of the American Chemical Society 115 (18), 8483-8484, 1993 | 58 | 1993 |
| Extending the cleavage rules for the hammerhead ribozyme: mutating adenosine15. 1 to inosine15. 1 changes the cleavage site specificity from N16. 2U16. 1H17 to N16. 2C16. 1H17 J Ludwig, M Blaschke, BS Sproat Nucleic acids research 26 (10), 2279-2285, 1998 | 52 | 1998 |
| Synthesis of α-P-modified nucleoside diphosphates with ethylenediamine P Li, Z Xu, H Liu, CK Wennefors, MI Dobrikov, J Ludwig, BR Shaw Journal of the American Chemical Society 127 (48), 16782-16783, 2005 | 45 | 2005 |
| Higher activation of TLR9 in plasmacytoid dendritic cells by microbial DNA compared with self-DNA based on CpG-specific recognition of phosphodiester DNA C Coch, N Busch, V Wimmenauer, E Hartmann, M Janke, ... Journal of leukocyte biology 86 (3), 663-670, 2009 | 42 | 2009 |
| n-Decyl-NHpppA2′ p5′ A2′ p5′ A a phosphatase-resistant, active pppA2′ p5′ A2′ p5′ A analog K Kariko, J Ludwig Biochemical and biophysical research communications 128 (2), 695-698, 1985 | 40 | 1985 |
