| Requirement for generation of H2O2 for platelet-derived growth factor signal transduction M Sundaresan, ZX Yu, VJ Ferrans, K Irani, T Finkel Science 270 (5234), 296-299, 1995 | 3151 | 1995 |
| Mitogenic signaling mediated by oxidants in Ras-transformed fibroblasts K Irani, Y Xia, JL Zweier, SJ Sollott, CJ Der, ER Fearon, M Sundaresan, ... Science 275 (5306), 1649-1652, 1997 | 2016 | 1997 |
| Oxidant signaling in vascular cell growth, death, and survival: a review of the roles of reactive oxygen species in smooth muscle and endothelial cell mitogenic and apoptotic … K Irani Circulation research 87 (3), 179-183, 2000 | 1036 | 2000 |
| SIRT1 promotes endothelium-dependent vascular relaxation by activating endothelial nitric oxide synthase I Mattagajasingh, CS Kim, A Naqvi, T Yamamori, TA Hoffman, SB Jung, ... Proceedings of the National Academy of Sciences 104 (37), 14855-14860, 2007 | 968 | 2007 |
| Regulation of reactive-oxygen-species generation in fibroblasts by Rac 1 M Sundaresan, ZX Yu, VJ Ferrans, DJ Sulciner, S GUTKIND, KJ IRANI, ... Biochemical Journal 318 (2), 379-382, 1996 | 617 | 1996 |
| Rac1 regulates a cytokine-stimulated, redox-dependent pathway necessary for NF-κB activation DJ Sulciner, K Irani, ZX Yu, VJ Ferrans, P Goldschmidt-Clermont, T Finkel Molecular and cellular biology, 1996 | 423 | 1996 |
| Rac1 inhibits TNF‐α‐induced endothelial cell apoptosis: dual regulation by reactive oxygen species SS Deshpande, P Angkeow, J Huang, M Ozaki, K Irani The FASEB Journal 14 (12), 1705-1714, 2000 | 305 | 2000 |
| Stat3 protects against Fas-induced liver injury by redox-dependent and-independent mechanisms S Haga, K Terui, HQ Zhang, S Enosawa, W Ogawa, H Inoue, T Okuyama, ... The Journal of clinical investigation 112 (7), 989-998, 2003 | 303 | 2003 |
| Inducible NO Synthase–Dependent S-Nitrosylation and Activation of Arginase1 Contribute to Age-Related Endothelial Dysfunction L Santhanam, HK Lim, HK Lim, V Miriel, T Brown, M Patel, S Balanson, ... Circulation research 101 (7), 692-702, 2007 | 222 | 2007 |
| Ras, superoxide and signal transduction. K Irani, PJ Goldschmidt-Clermont Biochemical pharmacology 55 (9), 1339-1346, 1998 | 218 | 1998 |
| SIRT1 deacetylates APE1 and regulates cellular base excision repair T Yamamori, J DeRicco, A Naqvi, TA Hoffman, I Mattagajasingh, ... Nucleic acids research 38 (3), 832-845, 2010 | 209 | 2010 |
| Vascular endothelial growth factor induces manganese‐superoxide dismutase expression in endothelial cells by a Racl‐regulated NADPH oxidase‐dependent mechanism MR Abid, JC Tsai, KC Spokes, SS Deshpande, K Irani, WC Aird The FASEB journal 15 (13), 2548-2550, 2001 | 206 | 2001 |
| Wall stiffness suppresses Akt/eNOS and cytoprotection in pulse-perfused endothelium X Peng, S Haldar, S Deshpande, K Irani, DA Kass Hypertension 41 (2), 378-381, 2003 | 187 | 2003 |
| Shear-induced tyrosine phosphorylation in endothelial cells requires Rac1-dependent production of ROS LH Yeh, YJ Park, RJ Hansalia, IS Ahmed, SS Deshpande, ... American Journal of Physiology-Cell Physiology 276 (4), C838-C847, 1999 | 183 | 1999 |
| Alterations in the expression of the apurinic/apyrimidinic endonuclease-1/redox factor-1 (APE/Ref-1) in human melanoma and identification of the therapeutic potential of … S Yang, K Irani, SE Heffron, F Jurnak, FL Meyskens Jr Molecular cancer therapeutics 4 (12), 1923-1935, 2005 | 180 | 2005 |
| Inhibition of the Rac1 GTPase protects against nonlethal ischemia/reperfusion‐induced necrosis and apoptosis in vivo M Ozaki, S S. Deshpande, P Angkeow, J Bellan, C J. Lowenstein, ... The FASEB journal 14 (2), 418-429, 2000 | 177 | 2000 |
| Redox factor-1: an extra-nuclear role in the regulation of endothelial oxidative stress and apoptosis P Angkeow, SS Deshpande, B Qi, YX Liu, YC Park, BH Jeon, M Ozaki, ... Cell Death & Differentiation 9 (7), 717-725, 2002 | 176 | 2002 |
| A requirement for the rac1 GTPase in the signal transduction pathway leading to cardiac myocyte hypertrophy. JB Pracyk, K Tanaka, DD Hegland, KS Kim, R Sethi, II Rovira, DR Blazina, ... The Journal of clinical investigation 102 (5), 929-937, 1998 | 167 | 1998 |
| MicroRNA miR-27b rescues bone marrow–derived angiogenic cell function and accelerates wound healing in type 2 diabetes mellitus JM Wang, J Tao, DD Chen, JJ Cai, K Irani, Q Wang, H Yuan, AF Chen Arteriosclerosis, thrombosis, and vascular biology 34 (1), 99-109, 2014 | 165 | 2014 |
| Protection from reoxygenation injury by inhibition of rac1. KS Kim, K Takeda, R Sethi, JB Pracyk, K Tanaka, YF Zhou, ZX Yu, ... The Journal of clinical investigation 101 (9), 1821-1826, 1998 | 164 | 1998 |
