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David Nedrud
David Nedrud
Bestätigte E-Mail-Adresse bei umn.edu - Startseite
Titel
Zitiert von
Zitiert von
Jahr
Targeted insertional mutagenesis libraries for deep domain insertion profiling
W Coyote-Maestas, D Nedrud, S Okorafor, Y He, D Schmidt
Nucleic acids research 48 (2), e11-e11, 2020
352020
Determinants of trafficking, conduction, and disease within a K+ channel revealed through multiparametric deep mutational scanning
W Coyote-Maestas, D Nedrud, Y He, D Schmidt
Elife 11, e76903, 2022
302022
Uncovering divergent evolution of α/β-hydrolases: a surprising residue substitution needed to convert Hevea brasiliensis hydroxynitrile lyase into an esterase
DM Nedrud, H Lin, G Lopez, SK Padhi, GA Legatt, RJ Kazlauskas
Chemical science 5 (11), 4265-4277, 2014
262014
Probing ion channel functional architecture and domain recombination compatibility by massively parallel domain insertion profiling
W Coyote-Maestas, D Nedrud, A Suma, Y He, KA Matreyek, DM Fowler, ...
Nature communications 12 (1), 7114, 2021
202021
Increasing the Reaction Rate of Hydroxynitrile Lyase from Hevea brasiliensis toward Mandelonitrile by Copying Active Site Residues from an Esterase that Accepts …
J Von Langermann, DM Nedrud, RJ Kazlauskas
ChemBioChem 15 (13), 1931-1938, 2014
162014
A large‐scale survey of pairwise epistasis reveals a mechanism for evolutionary expansion and specialization of PDZ domains
D Nedrud, W Coyote‐Maestas, D Schmidt
Proteins: Structure, Function, and Bioinformatics 89 (8), 899-914, 2021
142021
DIMPLE: deep insertion, deletion, and missense mutation libraries for exploring protein variation in evolution, disease, and biology
CB Macdonald, D Nedrud, PR Grimes, D Trinidad, JS Fraser, ...
Genome biology 24 (1), 36, 2023
112023
Deep insertion, deletion, and missense mutation libraries for exploring protein variation in evolution, disease, and biology
CB Macdonald, D Nedrud, PR Grimes, D Trinidad, JS Fraser, ...
BioRxiv, 2022.07. 26.501589, 2022
42022
DIMPLE library generation and assembly protocol
C Macdonald, D Nedrud, PR Grimes, D Trinidad, J Fraser, ...
12023
The biophysical basis of protein domain compatibility in ion channels
W Coyote-Maestas, D Nedrud, A Suma, Y He, KA Matreyek, DM Fowler, ...
bioRxiv, 2020.12. 09.418442, 2020
12020
A survey of pairwise epistasis supports an outside-in hierarchy of clade-specifying and function-defining residues in PSD95 PDZ3
D Nedrud, W Coyote-Maestas, D Schmidt
bioRxiv, 2020.06. 26.174375, 2020
12020
Multiparametric domain insertional profiling of adeno-associated virus VP1
MD Hoffmann, AC Zdechlik, Y He, D Nedrud, G Aslanidi, W Gordon, ...
Molecular Therapy-Methods & Clinical Development 31, 2023
2023
Deep insertional mutagenesis and multiplex assessment of phenotype reveals biophysical mechanisms of protein domain compatibility
D Schmidt, W Coyote-Maestas, D Nedrud, M Hoffmann
Biophysical Journal 121 (3), 156a, 2022
2022
Deconvoluting receptor trafficking, regulation, and function using massively parallel assays
D Nedrud, Y He, D Schmidt, J Fraser, W Coyote-Maestas
Biophysical Journal 121 (3), 2a, 2022
2022
The Biophysical basis of protein domain compatibility
D Schmidt, W Coyote-Maestas, D Nedrud, A Suma, Y He, KA Matreyek, ...
PROTEIN SCIENCE 30, 73-74, 2021
2021
Comprehensive Domain Insertion Profiling to Study Inward Rectifier K+ Channel Folding Robustness
W Coyote-Maestas, D Nedrud, Y He, D Schmidt
Biophysical Journal 120 (3), 338a-339a, 2021
2021
Programmed mutagenesis and high-throughput methods to study protein recombination and epistasis
D Nedrud
University of Minnesota, 2021
2021
Deep Domain Insertion Profiling is a Window into Inward Rectifier K+ Channel Dynamics and Gating
W Coyote-Maestas, A Suma, D Nedrud, V Carnevale, D Schmidt
Biophysical Journal 118 (3), 320a, 2020
2020
PROFILING LATENT AND ENGINEERABLE ALLOSTERY IN ION CHANNELS THROUGH SYSTEMATIC DOMAIN INSERTION
D Schmidt, W Coyote-Maestas, D Nedrud, Y He, C Myers
PROTEIN SCIENCE 28, 95-95, 2019
2019
Efficient mesoscale phenotypic screening in cultured primary neuron culture
D Nedrud, Y He, D Schmidt
bioRxiv, 562298, 2019
2019
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