| Cpf1 is a single RNA-guided endonuclease of a class 2 CRISPR-Cas system B Zetsche, JS Gootenberg, OO Abudayyeh, IM Slaymaker, KS Makarova, ... cell 163 (3), 759-771, 2015 | 4670 | 2015 |
| Rationally engineered Cas9 nucleases with improved specificity IM Slaymaker, L Gao, B Zetsche, DA Scott, WX Yan, F Zhang Science 351 (6268), 84-88, 2016 | 2583 | 2016 |
| C2c2 is a single-component programmable RNA-guided RNA-targeting CRISPR effector OO Abudayyeh, JS Gootenberg, S Konermann, J Joung, IM Slaymaker, ... Science 353 (6299), aaf5573, 2016 | 2100 | 2016 |
| Crystal structure of Cpf1 in complex with guide RNA and target DNA T Yamano, H Nishimasu, B Zetsche, H Hirano, IM Slaymaker, Y Li, ... Cell 165 (4), 949-962, 2016 | 682 | 2016 |
| Cas13b is a type VI-B CRISPR-associated RNA-guided RNase differentially regulated by accessory proteins Csx27 and Csx28 AA Smargon, DBT Cox, NK Pyzocha, K Zheng, IM Slaymaker, ... Molecular cell 65 (4), 618-630. e7, 2017 | 568 | 2017 |
| CRISPR enzymes and systems F Zhang, B Zetsche, I Slaymaker, J Gootenberg, OO Abudayyeh US Patent 9,790,490, 2017 | 488 | 2017 |
| Directed evolution of adenine base editors with increased activity and therapeutic application NM Gaudelli, DK Lam, HA Rees, NM Solá-Esteves, LA Barrera, DA Born, ... Nature biotechnology 38 (7), 892-900, 2020 | 419 | 2020 |
| Base editing: advances and therapeutic opportunities EM Porto, AC Komor, IM Slaymaker, GW Yeo Nature Reviews Drug Discovery 19 (12), 839-859, 2020 | 270 | 2020 |
| Chd8 mutation leads to autistic-like behaviors and impaired striatal circuits RJ Platt, Y Zhou, IM Slaymaker, AS Shetty, NR Weisbach, JA Kim, ... Cell reports 19 (2), 335-350, 2017 | 195 | 2017 |
| High-resolution structure of Cas13b and biochemical characterization of RNA targeting and cleavage IM Slaymaker, P Mesa, MJ Kellner, S Kannan, E Brignole, J Koob, ... Cell reports 26 (13), 3741-3751. e5, 2019 | 100 | 2019 |
| Rationally designed base editors for precise editing of the sickle cell disease mutation SH Chu, M Packer, H Rees, D Lam, Y Yu, J Marshall, LI Cheng, D Lam, ... The CRISPR Journal 4 (2), 169-177, 2021 | 66 | 2021 |
| Crispr enzymes and systems F Zhang, B Zetsche, JS Gootenberg, OO Abudayyeh, I Slaymaker US Patent 11,781,172, 2023 | 41 | 2023 |
| CRISPR enzymes and systems F Zhang, B Zetsche, I Slaymaker, J Gootenberg, OO Abudayyeh US Patent 10,669,540, 2020 | 41 | 2020 |
| MCM structure and mechanics: what we have learned from archaeal MCM IM Slaymaker, XS Chen The Eukaryotic Replisome: a Guide to Protein Structure and Function, 89-111, 2012 | 34 | 2012 |
| Crispr enzyme mutations reducing off-target effects F Zhang, L Gao, B Zetsche, I Slaymaker US Patent 10,876,100, 2020 | 33 | 2020 |
| Mini-chromosome maintenance complexes form a filament to remodel DNA structure and topology IM Slaymaker, Y Fu, DB Toso, N Ranatunga, A Brewster, SL Forsburg, ... Nucleic acids research 41 (5), 3446-3456, 2013 | 32 | 2013 |
| CRISPR–Cas9 mediated DNA unwinding detected using site-directed spin labeling NS Tangprasertchai, R Di Felice, X Zhang, IM Slaymaker, ... ACS chemical biology 12 (6), 1489-1493, 2017 | 25 | 2017 |
| Mutational analysis of an archaeal minichromosome maintenance protein exterior hairpin reveals critical residues for helicase activity and DNA binding AS Brewster, IM Slaymaker, SA Afif, XS Chen BMC Molecular Biology 11, 1-8, 2010 | 22 | 2010 |
| Engineering Cas9 for human genome editing IM Slaymaker, NM Gaudelli Current Opinion in Structural Biology 69, 86-98, 2021 | 19 | 2021 |
| CRISPR enzymes and systems F Zhang, B Zetsche, JS Gootenberg, OO Abudayyeh, I Slaymaker US Patent 10,648,020, 2020 | 18 | 2020 |
