Non-genetic origins of cell-to-cell variability in TRAIL-induced apoptosis SL Spencer, S Gaudet, JG Albeck, JM Burke, PK Sorger Nature 459 (7245), 428-432, 2009 | 987 | 2009 |
The proliferation-quiescence decision is controlled by a bifurcation in CDK2 activity at mitotic exit SL Spencer, SD Cappell, FC Tsai, KW Overton, CL Wang, T Meyer Cell 155 (2), 369-383, 2013 | 381 | 2013 |
Measuring and modeling apoptosis in single cells SL Spencer, PK Sorger Cell 144 (6), 926-939, 2011 | 320 | 2011 |
Modeling a snap-action, variable-delay switch controlling extrinsic cell death JG Albeck, JM Burke, SL Spencer, DA Lauffenburger, PK Sorger PLoS Biol 6 (12), e299, 2008 | 315 | 2008 |
Non-genetic cell-to-cell variability and the consequences for pharmacology M Niepel, SL Spencer, PK Sorger Current opinion in chemical biology 13 (5-6), 556-561, 2009 | 206 | 2009 |
Irreversible APCCdh1 inactivation underlies the point of no return for cell-cycle entry SD Cappell, M Chung, A Jaimovich, SL Spencer, T Meyer Cell 166 (1), 167-180, 2016 | 130 | 2016 |
Modeling somatic evolution in tumorigenesis SL Spencer, RA Gerety, KJ Pienta, S Forrest PLoS Comput Biol 2 (8), e108, 2006 | 129 | 2006 |
Synthesis: cancer research meets evolutionary biology JW Pepper, C Scott Findlay, R Kassen, SL Spencer, CC Maley Evolutionary applications 2 (1), 62-70, 2009 | 118 | 2009 |
Ki67 is a graded rather than a binary marker of proliferation versus quiescence I Miller, M Min, C Yang, C Tian, S Gookin, D Carter, SL Spencer Cell reports 24 (5), 1105-1112. e5, 2018 | 109 | 2018 |
An ordinary differential equation model for the multistep transformation to cancer SL Spencer, MJ Berryman, JA García, D Abbott Journal of Theoretical Biology 231 (4), 515-524, 2004 | 101 | 2004 |
Endogenous replication stress in mother cells leads to quiescence of daughter cells M Arora, J Moser, H Phadke, AA Basha, SL Spencer Cell reports 19 (7), 1351-1364, 2017 | 94 | 2017 |
Exploring the contextual sensitivity of factors that determine cell-to-cell variability in receptor-mediated apoptosis S Gaudet, SL Spencer, WW Chen, PK Sorger PLoS Comput Biol 8 (4), e1002482, 2012 | 87 | 2012 |
Cells surviving fractional killing by TRAIL exhibit transient but sustainable resistance and inflammatory phenotypes DA Flusberg, J Roux, SL Spencer, PK Sorger Molecular biology of the cell 24 (14), 2186-2200, 2013 | 76 | 2013 |
Basal p21 controls population heterogeneity in cycling and quiescent cell cycle states KW Overton, SL Spencer, WL Noderer, T Meyer, CL Wang Proceedings of the National Academy of Sciences 111 (41), E4386-E4393, 2014 | 74 | 2014 |
Systematic calibration of a cell signaling network model KA Kim, SL Spencer, JG Albeck, JM Burke, PK Sorger, S Gaudet, DH Kim BMC bioinformatics 11 (1), 202, 2010 | 53 | 2010 |
Control of the Restriction Point by Rb and p21 J Moser, I Miller, D Carter, SL Spencer Proceedings of the National Academy of Sciences 115 (35), E8219-E8227, 2018 | 43 | 2018 |
A map of protein dynamics during cell-cycle progression and cell-cycle exit S Gookin, M Min, H Phadke, M Chung, J Moser, I Miller, D Carter, ... PLoS biology 15 (9), e2003268, 2017 | 37 | 2017 |
p53 suppresses muscle differentiation at the myogenin step in response to genotoxic stress WCL Yang ZJ, Broz DK, Noderer WL, Ferreira JP, Overton KW, Spencer SL, Meyer ... Cell Death and Differentiation 22 (4), 560-73, 2015 | 34 | 2015 |
Temporal integration of mitogen history in mother cells controls proliferation of daughter cells M Min, Y Rong, C Tian, SL Spencer Science 368 (6496), 1261-1265, 2020 | 17 | 2020 |
Spontaneously slow-cycling subpopulations of human cells originate from activation of stress-response pathways M Min, SL Spencer PLoS biology 17 (3), e3000178, 2019 | 13 | 2019 |