| Structural basis of membrane disruption and cellular toxicity by α-synuclein oligomers G Fusco, SW Chen, PTF Williamson, R Cascella, M Perni, JA Jarvis, ... Science 358 (6369), 1440-1443, 2017 | 586 | 2017 |
| Oxidative stress in neurodegenerative diseases: from a mitochondrial point of view G Cenini, A Lloret, R Cascella Oxidative medicine and cellular longevity 2019, 2019 | 400 | 2019 |
| A natural product inhibits the initiation of α-synuclein aggregation and suppresses its toxicity M Perni, C Galvagnion, A Maltsev, G Meisl, MBD Müller, PK Challa, ... Proceedings of the National Academy of Sciences 114 (6), E1009-E1017, 2017 | 300 | 2017 |
| Toxicity of protein oligomers is rationalized by a function combining size and surface hydrophobicity B Mannini, E Mulvihill, C Sgromo, R Cascella, R Khodarahmi, ... ACS chemical biology 9 (10), 2309-2317, 2014 | 206 | 2014 |
| Molecular mechanisms used by chaperones to reduce the toxicity of aberrant protein oligomers B Mannini, R Cascella, M Zampagni, M van Waarde-Verhagen, S Meehan, ... Proceedings of the National Academy of Sciences 109 (31), 12479-12484, 2012 | 168 | 2012 |
| The release of toxic oligomers from α-synuclein fibrils induces dysfunction in neuronal cells R Cascella, SW Chen, A Bigi, JD Camino, CK Xu, CM Dobson, F Chiti, ... Nature communications 12 (1), 1814, 2021 | 147 | 2021 |
| Trodusquemine enhances Aβ42 aggregation but suppresses its toxicity by displacing oligomers from cell membranes R Limbocker, S Chia, FS Ruggeri, M Perni, R Cascella, GT Heller, G Meisl, ... Nature communications 10 (1), 225, 2019 | 133 | 2019 |
| Oleuropein aglycone induces autophagy via the AMPK/mTOR signalling pathway: a mechanistic insight S Rigacci, C Miceli, C Nediani, A Berti, R Cascella, D Pantano, ... Oncotarget 6 (34), 35344, 2015 | 132 | 2015 |
| Binding affinity of amyloid oligomers to cellular membranes is a generic indicator of cellular dysfunction in protein misfolding diseases E Evangelisti, R Cascella, M Becatti, G Marrazza, CM Dobson, F Chiti, ... Scientific reports 6 (1), 32721, 2016 | 126 | 2016 |
| Proteostasis failure in neurodegenerative diseases: focus on oxidative stress A Höhn, A Tramutola, R Cascella Oxidative medicine and cellular longevity 2020, 2020 | 121 | 2020 |
| Multistep Inhibition of α-Synuclein Aggregation and Toxicity in Vitro and in Vivo by Trodusquemine M Perni, P Flagmeier, R Limbocker, R Cascella, FA Aprile, C Galvagnion, ... ACS chemical biology 13 (8), 2308-2319, 2018 | 104 | 2018 |
| Calcium dyshomeostasis in Alzheimer’s disease pathogenesis R Cascella, C Cecchi International journal of molecular sciences 22 (9), 4914, 2021 | 94 | 2021 |
| Membrane lipid composition and its physicochemical properties define cell vulnerability to aberrant protein oligomers E Evangelisti, C Cecchi, R Cascella, C Sgromo, M Becatti, CM Dobson, ... Journal of cell science 125 (10), 2416-2427, 2012 | 89 | 2012 |
| Selenium and zinc: Two key players against cadmium-induced neuronal toxicity JJV Branca, G Morucci, M Maresca, B Tenci, R Cascella, F Paternostro, ... Toxicology in Vitro 48, 159-169, 2018 | 86 | 2018 |
| Transthyretin suppresses the toxicity of oligomers formed by misfolded proteins in vitro R Cascella, S Conti, B Mannini, X Li, JN Buxbaum, B Tiribilli, F Chiti, ... Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease 1832 (12 …, 2013 | 85 | 2013 |
| Quantification of the Relative Contributions of Loss-of-function and Gain-of-function Mechanisms in TAR DNA-binding Protein 43 (TDP-43) Proteinopathies R Cascella, C Capitini, G Fani, CM Dobson, C Cecchi, F Chiti Journal of Biological Chemistry 291 (37), 19437-19448, 2016 | 81 | 2016 |
| TDP-43 inclusion bodies formed in bacteria are structurally amorphous, non-amyloid and inherently toxic to neuroblastoma cells C Capitini, S Conti, M Perni, F Guidi, R Cascella, A De Poli, A Penco, ... PloS one 9 (1), e86720, 2014 | 81 | 2014 |
| Extracellular chaperones prevent Aβ42-induced toxicity in rat brains R Cascella, S Conti, F Tatini, E Evangelisti, T Scartabelli, F Casamenti, ... Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease 1832 (8 …, 2013 | 77 | 2013 |
| A comparison of the biochemical modifications caused by toxic and non‐toxic protein oligomers in cells M Zampagni, R Cascella, F Casamenti, C Grossi, E Evangelisti, D Wright, ... Journal of cellular and molecular medicine 15 (10), 2106-2116, 2011 | 70 | 2011 |
| Allele specific Taqman-based real-time PCR assay to quantify circulating BRAFV600E mutated DNA in plasma of melanoma patients P Pinzani, F Salvianti, R Cascella, D Massi, V De Giorgi, M Pazzagli, ... Clinica Chimica Acta 411 (17-18), 1319-1324, 2010 | 68 | 2010 |
