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Leiyun Weng, PhD
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The E3 ubiquitin ligase TRIM21 negatively regulates the innate immune response to intracellular double-stranded DNA
Z Zhang, M Bao, N Lu, L Weng, B Yuan, YJ Liu
Nature immunology 14 (2), 172-178, 2013
2302013
Identification of a role for TRIM29 in the control of innate immunity in the respiratory tract
J Xing, L Weng, B Yuan, Z Wang, L Jia, R Jin, H Lu, XC Li, YJ Liu, ...
Nature immunology 17 (12), 1373-1380, 2016
1392016
Human NLRP3 inflammasome senses multiple types of bacterial RNAs
W Sha, H Mitoma, S Hanabuchi, M Bao, L Weng, N Sugimoto, Y Liu, ...
Proceedings of the National Academy of Sciences 111 (45), 16059-16064, 2014
1362014
Self-enhancement of hepatitis C virus replication by promotion of specific sphingolipid biosynthesis
Y Hirata, K Ikeda, M Sudoh, Y Tokunaga, A Suzuki, L Weng, M Ohta, ...
Public Library of Science 8 (8), e1002860, 2012
842012
Sphingomyelin activates hepatitis C virus RNA polymerase in a genotype-specific manner
L Weng, Y Hirata, M Arai, M Kohara, T Wakita, K Watashi, K Shimotohno, ...
Journal of virology 84 (22), 11761-11770, 2010
842010
The E3 ubiquitin ligase tripartite motif 33 is essential for cytosolic RNA–induced NLRP3 inflammasome activation
L Weng, H Mitoma, C Tricot, M Bao, Y Liu, Z Zhang, YJ Liu
The Journal of Immunology 193 (7), 3676-3682, 2014
822014
DHX15 senses double-stranded RNA in myeloid dendritic cells
H Lu, N Lu, L Weng, B Yuan, Y Liu, Z Zhang
The Journal of Immunology 193 (3), 1364-1372, 2014
672014
RNA polymerase activity and specific RNA structure are required for efficient HCV replication in cultured cells
A Murayama, L Weng, T Date, D Akazawa, X Tian, T Suzuki, T Kato, ...
PLoS pathogens 6 (4), e1000885, 2010
632010
The interaction between the helicase DHX33 and IPS-1 as a novel pathway to sense double-stranded RNA and RNA viruses in myeloid dendritic cells
Y Liu, N Lu, B Yuan, L Weng, F Wang, YJ Liu, Z Zhang
Cellular & molecular immunology 11 (1), 49-57, 2014
602014
Biochemical characterization of enterovirus 71 3D RNA polymerase
H Jiang, L Weng, N Zhang, M Arita, R Li, L Chen, T Toyoda
Biochimica et Biophysica Acta (BBA)-Gene Regulatory Mechanisms 1809 (3), 211-219, 2011
392011
NFATC3 promotes IRF7 transcriptional activity in plasmacytoid dendritic cells
M Bao, Y Wang, Y Liu, P Shi, H Lu, W Sha, L Weng, S Hanabuchi, J Qin, ...
Journal of Experimental Medicine 213 (11), 2383-2398, 2016
292016
Biochemical and kinetic analysis of the influenza virus RNA polymerase purified from insect cells
S Zhang, L Weng, L Geng, J Wang, J Zhou, V Deubel, P Buchy, T Toyoda
Biochemical and biophysical research communications 391 (1), 570-574, 2010
272010
Modification of hepatitis C virus 1b RNA polymerase to make a highly active JFH1-type polymerase by mutation of the thumb domain
L Weng, J Du, J Zhou, J Ding, T Wakita, M Kohara, T Toyoda
Archives of virology 154, 765-773, 2009
182009
Effect of the methyltransferase domain of Japanese encephalitis virus NS5 on the polymerase activity
Q Wang, L Weng, X Tian, D Counor, J Sun, Y Mao, V Deubel, H Okada, ...
Biochimica et Biophysica Acta (BBA)-Gene Regulatory Mechanisms 1819 (5), 411-418, 2012
172012
The N-terminal helix α0 of hepatitis C virus NS3 protein dictates the subcellular localization and stability of NS3/NS4A complex
Y He, L Weng, R Li, L Li, T Toyoda, J Zhong
Virology 422 (2), 214-223, 2012
162012
Inhibition of influenza virus replication by constrained peptides targeting nucleoprotein
H Jiang, Y Xu, L Li, L Weng, Q Wang, S Zhang, B Jia, H Hu, Y He, Y Jacob, ...
Antiviral Chemistry and Chemotherapy 22 (3), 119-130, 2011
132011
PA from an H5N1 highly pathogenic avian influenza virus activates viral transcription and replication and induces apoptosis and interferon expression at an early stage of infection
Q Wang, S Zhang, H Jiang, J Wang, L Weng, Y Mao, S Sekiguchi, F Yasui, ...
Virology journal 9, 1-13, 2012
122012
Different mechanisms of hepatitis C virus RNA polymerase activation by cyclophilin A and B in vitro
L Weng, X Tian, Y Gao, K Watashi, K Shimotohno, T Wakita, M Kohara, ...
Biochimica et Biophysica Acta (BBA)-General Subjects 1820 (12), 1886-1892, 2012
92012
Detergent-induced activation of the hepatitis C virus genotype 1b RNA polymerase
L Weng, M Kohara, T Wakita, K Shimotohno, T Toyoda
Gene 496 (2), 79-87, 2012
52012
Fluorescent primer-based in vitro transcription system of viral RNA-dependent RNA polymerases.
Q Wang, L Weng, H Jiang, S Zhang, T Toyoda
Analytical Biochemistry 433 (2), 92-94, 2012
12012
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