| A potent mechanism-inspired O-GlcNAcase inhibitor that blocks phosphorylation of tau in vivo SA Yuzwa, MS Macauley, JE Heinonen, X Shan, RJ Dennis, Y He, ... Nature chemical biology 4 (8), 483-490, 2008 | 770 | 2008 |
| Increasing O-GlcNAc slows neurodegeneration and stabilizes tau against aggregation SA Yuzwa, X Shan, MS Macauley, T Clark, Y Skorobogatko, K Vosseller, ... Nature chemical biology 8 (4), 393-399, 2012 | 603 | 2012 |
| The emerging link between O-GlcNAc and Alzheimer disease Y Zhu, X Shan, SA Yuzwa, DJ Vocadlo Journal of Biological Chemistry 289 (50), 34472-34481, 2014 | 281 | 2014 |
| Enhanced de novo neurogenesis and dopaminergic neurogenesis in the substantia nigra of 1‐methyl‐4‐phyenyl‐1, 2, 3, 6‐tetrahydropyridine‐induced Parkinson's disease‐like mice X Shan, L Chi, M Bishop, C Luo, L Lien, Z Zhang, R Liu Stem cells 24 (5), 1280-1287, 2006 | 152 | 2006 |
| Pharmacological inhibition of O-GlcNAcase (OGA) prevents cognitive decline and amyloid plaque formation in bigenic tau/APP mutant mice SA Yuzwa, X Shan, BA Jones, G Zhao, ML Woodward, X Li, Y Zhu, ... Molecular neurodegeneration 9, 1-14, 2014 | 140 | 2014 |
| Manganese superoxide dismutase protects mouse cortical neurons from chronic intermittent hypoxia-mediated oxidative damage X Shan, L Chi, Y Ke, C Luo, S Qian, D Gozal, R Liu Neurobiology of disease 28 (2), 206-215, 2007 | 128 | 2007 |
| Mislocalization of TDP-43 in the G93A mutant SOD1 transgenic mouse model of ALS X Shan, D Vocadlo, C Krieger Neuroscience letters 458 (2), 70-74, 2009 | 96 | 2009 |
| Elevation of Global O-GlcNAc in rodents using a selective O-GlcNAcase inhibitor does not cause insulin resistance or perturb glucohomeostasis MS Macauley, X Shan, SA Yuzwa, TM Gloster, DJ Vocadlo Chemistry & biology 17 (9), 949-958, 2010 | 86 | 2010 |
| Fluorescence-quenched substrates for live cell imaging of human glucocerebrosidase activity AK Yadav, DL Shen, X Shan, X He, AR Kermode, DJ Vocadlo Journal of the American Chemical Society 137 (3), 1181-1189, 2015 | 75 | 2015 |
| Metabolic inhibitors of O‐GlcNAc transferase that act in vivo implicate decreased O‐GlcNAc levels in leptin‐mediated nutrient sensing TW Liu, WF Zandberg, TM Gloster, L Deng, KD Murray, X Shan, ... Angewandte Chemie 130 (26), 7770-7774, 2018 | 65 | 2018 |
| Reduced protein O-glycosylation in the nervous system of the mutant SOD1 transgenic mouse model of amyotrophic lateral sclerosis X Shan, DJ Vocadlo, C Krieger Neuroscience letters 516 (2), 296-301, 2012 | 57 | 2012 |
| Pharmacological inhibition of O-GlcNAcase enhances autophagy in brain through an mTOR-independent pathway Y Zhu, X Shan, F Safarpour, N Erro Go, N Li, A Shan, MC Huang, M Deen, ... ACS Chemical Neuroscience 9 (6), 1366-1379, 2018 | 52 | 2018 |
| A convenient approach to stereoisomeric iminocyclitols: generation of potent brain‐permeable OGA inhibitors M Bergeron‐Brlek, J Goodwin‐Tindall, N Cekic, C Roth, WF Zandberg, ... Angewandte Chemie International Edition 54 (51), 15429-15433, 2015 | 47 | 2015 |
| Magnetic resonance microscopy and immunohistochemistry of the CNS of the mutant SOD murine model of ALS reveals widespread neural deficits MS Petrik, JMB Wilson, SC Grant, SJ Blackband, RC Tabata, X Shan, ... NeuroMolecular Medicine 9, 216-229, 2007 | 33 | 2007 |
| Erro Go Y Zhu, X Shan, F Safarpour N., Li, N., Shan, A., Huang, MC, Deen, M., Holicek, V., Ashmus, R., Madden …, 2018 | 28 | 2018 |
| Enhanced de novo neurogenesis and dopaminergic neurogenesis in the substantia nigra of MPTP-induced Parkinson’s disease-like mice X Shan, L Chi, M Bishop, C Luo, L Lien, Z Zhang, R Liu Stem cells (Dayton, Ohio) 24 (5), 1280, 2006 | 25 | 2006 |
| Increased phospho-adducin immunoreactivity in a murine model of amyotrophic lateral sclerosis X Shan, JH Hu, FS Cayabyab, C Krieger Neuroscience 134 (3), 833-846, 2005 | 16 | 2005 |
| Quantifying lysosomal glycosidase activity within cells using bis-acetal substrates S Cecioni, RA Ashmus, PA Gilormini, S Zhu, X Chen, X Shan, C Gros, ... Nature Chemical Biology 18 (3), 332-341, 2022 | 12 | 2022 |
| A versatile fluorescence-quenched substrate for quantitative measurement of glucocerebrosidase activity within live cells MC Deen, Y Zhu, C Gros, N Na, PA Gilormini, DL Shen, S Bhosale, ... Proceedings of the National Academy of Sciences 119 (29), e2200553119, 2022 | 11 | 2022 |
| Selective fluorogenic β-glucocerebrosidase substrates for convenient analysis of enzyme activity in cell and tissue homogenates MC Deen, C Proceviat, X Shan, L Wu, DL Shen, GJ Davies, DJ Vocadlo ACS Chemical Biology 15 (4), 824-829, 2020 | 11 | 2020 |
David VocadloProfessor of Chemistry, Simon Fraser UniversityVerified email at sfu.ca
