| Structural basis for DNA damage–dependent poly (ADP-ribosyl) ation by human PARP-1 MF Langelier, JL Planck, S Roy, JM Pascal Science 336 (6082), 728-732, 2012 | 683 | 2012 |
| Dual roles of PARP-1 promote cancer growth and progression MJ Schiewer, JF Goodwin, S Han, JC Brenner, MA Augello, JL Dean, ... Cancer discovery 2 (12), 1134-1149, 2012 | 461 | 2012 |
| Human DNA ligase I completely encircles and partially unwinds nicked DNA JM Pascal, PJ O'Brien, AE Tomkinson, T Ellenberger Nature 432 (7016), 473-478, 2004 | 391 | 2004 |
| DNA ligases: structure, reaction mechanism, and function AE Tomkinson, S Vijayakumar, JM Pascal, T Ellenberger Chemical reviews 106 (2), 687-699, 2006 | 337 | 2006 |
| A third zinc-binding domain of human poly (ADP-ribose) polymerase-1 coordinates DNA-dependent enzyme activation MF Langelier, KM Servent, EE Rogers, JM Pascal Journal of biological chemistry 283 (7), 4105-4114, 2008 | 309 | 2008 |
| Use of quantitative molecular diagnostic methods to assess the aetiology, burden, and clinical characteristics of diarrhoea in children in low-resource settings: a reanalysis … JA Platts-Mills, J Liu, ET Rogawski, F Kabir, P Lertsethtakarn, M Siguas, ... The Lancet Global Health 6 (12), e1309-e1318, 2018 | 307 | 2018 |
| The comings and goings of PARP-1 in response to DNA damage JM Pascal DNA repair 71, 177-182, 2018 | 307 | 2018 |
| PARP-1 activation requires local unfolding of an autoinhibitory domain JM Dawicki-McKenna, MF Langelier, JE DeNizio, AA Riccio, CD Cao, ... Molecular cell 60 (5), 755-768, 2015 | 305 | 2015 |
| Structural basis of detection and signaling of DNA single-strand breaks by human PARP-1 S Eustermann, WF Wu, MF Langelier, JC Yang, LE Easton, AA Riccio, ... Molecular cell 60 (5), 742-754, 2015 | 299 | 2015 |
| Use of quantitative molecular diagnostic methods to investigate the effect of enteropathogen infections on linear growth in children in low-resource settings: longitudinal … ET Rogawski, J Liu, JA Platts-Mills, F Kabir, P Lertsethtakarn, M Siguas, ... The Lancet Global Health 6 (12), e1319-e1328, 2018 | 291 | 2018 |
| Crystal structures of poly (ADP-ribose) polymerase-1 (PARP-1) zinc fingers bound to DNA: structural and functional insights into DNA-dependent PARP-1 activity MF Langelier, JL Planck, S Roy, JM Pascal Journal of biological chemistry 286 (12), 10690-10701, 2011 | 285 | 2011 |
| PARP-2 and PARP-3 are selectively activated by 5′ phosphorylated DNA breaks through an allosteric regulatory mechanism shared with PARP-1 MF Langelier, AA Riccio, JM Pascal Nucleic acids research 42 (12), 7762-7775, 2014 | 251 | 2014 |
| PARP-1 mechanism for coupling DNA damage detection to poly (ADP-ribose) synthesis MF Langelier, JM Pascal Current opinion in structural biology 23 (1), 134-143, 2013 | 228 | 2013 |
| Structural basis for allosteric PARP-1 retention on DNA breaks L Zandarashvili, MF Langelier, UK Velagapudi, MA Hancock, JD Steffen, ... Science 368 (6486), eaax6367, 2020 | 225 | 2020 |
| Causal pathways from enteropathogens to environmental enteropathy: findings from the MAL-ED birth cohort study MN Kosek, T Ahmed, Z Bhutta, L Caulfield, R Guerrant, E Houpt, G Kang, ... EBioMedicine 18, 109-117, 2017 | 225 | 2017 |
| The Zn3 domain of human poly (ADP-ribose) polymerase-1 (PARP-1) functions in both DNA-dependent poly (ADP-ribose) synthesis activity and chromatin compaction MF Langelier, DD Ruhl, JL Planck, WL Kraus, JM Pascal Journal of biological chemistry 285 (24), 18877-18887, 2010 | 210 | 2010 |
| NAD+ analog reveals PARP-1 substrate-blocking mechanism and allosteric communication from catalytic center to DNA-binding domains MF Langelier, L Zandarashvili, PM Aguiar, BE Black, JM Pascal Nature communications 9 (1), 844, 2018 | 191 | 2018 |
| ADP‐ribosyltransferases, an update on function and nomenclature B Lüscher, I Ahel, M Altmeyer, A Ashworth, P Bai, P Chang, M Cohen, ... The FEBS journal 289 (23), 7399-7410, 2022 | 178 | 2022 |
| Epidemiology and Impact of Campylobacter Infection in Children in 8 Low-Resource Settings: Results From the MAL-ED Study C Amour, J Gratz, E Mduma, E Svensen, ET Rogawski, M McGrath, ... Clinical Infectious Diseases 63 (9), 1171-1179, 2016 | 175 | 2016 |
| A flexible interface between DNA ligase and PCNA supports conformational switching and efficient ligation of DNA JM Pascal, OV Tsodikov, GL Hura, W Song, EA Cotner, S Classen, ... Molecular cell 24 (2), 279-291, 2006 | 169 | 2006 |
