Jae Jin Chae
Jae Jin Chae
Bestätigte E-Mail-Adresse bei mail.nih.gov
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A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases
RC Coll, AAB Robertson, JJ Chae, SC Higgins, R Muñoz-Planillo, ...
Nature medicine 21 (3), 248-255, 2015
10462015
De novo CIAS1 mutations, cytokine activation, and evidence for genetic heterogeneity in patients with neonatal‐onset multisystem inflammatory disease (NOMID …
I Aksentijevich, M Nowak, M Mallah, JJ Chae, WT Watford, SR Hofmann, ...
Arthritis & Rheumatism 46 (12), 3340-3348, 2002
7012002
The calcium-sensing receptor regulates the NLRP3 inflammasome through Ca2+ and cAMP
GS Lee, N Subramanian, AI Kim, I Aksentijevich, R Goldbach-Mansky, ...
Nature 492 (7427), 123-127, 2012
5892012
The B30. 2 domain of pyrin, the familial Mediterranean fever protein, interacts directly with caspase-1 to modulate IL-1β production
JJ Chae, G Wood, SL Masters, K Richard, G Park, BJ Smith, DL Kastner
Proceedings of the National Academy of Sciences 103 (26), 9982-9987, 2006
5482006
Targeted disruption of pyrin, the FMF protein, causes heightened sensitivity to endotoxin and a defect in macrophage apoptosis
JJ Chae, HD Komarow, J Cheng, G Wood, N Raben, PP Liu, DL Kastner
Molecular cell 11 (3), 591-604, 2003
4652003
Early-onset stroke and vasculopathy associated with mutations in ADA2
Q Zhou, D Yang, AK Ombrello, AV Zavialov, C Toro, AV Zavialov, ...
New England Journal of Medicine 370 (10), 911-920, 2014
4382014
Gain-of-function Pyrin mutations induce NLRP3 protein-independent interleukin-1β activation and severe autoinflammation in mice
JJ Chae, YH Cho, GS Lee, J Cheng, PP Liu, L Feigenbaum, SI Katz, ...
Immunity 34 (5), 755-768, 2011
3692011
Mutation and haplotype studies of familial Mediterranean fever reveal new ancestral relationships and evidence for a high carrier frequency with reduced penetrance in the …
I Aksentijevich, Y Torosyan, J Samuels, M Centola, E Pras, JJ Chae, ...
The American Journal of Human Genetics 64 (4), 949-962, 1999
3071999
Loss-of-function mutations in TNFAIP3 leading to A20 haploinsufficiency cause an early-onset autoinflammatory disease
Q Zhou, H Wang, DM Schwartz, M Stoffels, YH Park, Y Zhang, D Yang, ...
Nature genetics 48 (1), 67-73, 2016
2872016
The expanding spectrum of systemic autoinflammatory disorders and their rheumatic manifestations
KM Hull, N Shoham, JJ Chae, I Aksentijevich, DL Kastner
Current opinion in rheumatology 15 (1), 61-69, 2003
2502003
Pyrin inflammasome activation and RhoA signaling in the autoinflammatory diseases FMF and HIDS
YH Park, G Wood, DL Kastner, JJ Chae
Nature immunology 17 (8), 914, 2016
2362016
Familial mediterranean fever with a single MEFV mutation: Where is the second hit?
MG Booty, JJ Chae, SL Masters, EF Remmers, B Barham, JM Le, ...
Arthritis & Rheumatism: Official Journal of the American College of …, 2009
2312009
The familial Mediterranean fever protein, pyrin, associates with microtubules and colocalizes with actin filaments
E Mansfield, JJ Chae, HD Komarow, TM Brotz, DM Frucht, I Aksentijevich, ...
Blood, The Journal of the American Society of Hematology 98 (3), 851-859, 2001
2312001
Advances in the understanding of familial Mediterranean fever and possibilities for targeted therapy
JJ Chae, I Aksentijevich, DL Kastner
British journal of haematology 146 (5), 467-478, 2009
2112009
Concerted action of wild-type and mutant TNF receptors enhances inflammation in TNF receptor 1-associated periodic fever syndrome
A Simon, H Park, R Maddipati, AA Lobito, AC Bulua, AJ Jackson, JJ Chae, ...
Proceedings of the National Academy of Sciences 107 (21), 9801-9806, 2010
1752010
The familial Mediterranean fever protein, pyrin, is cleaved by caspase-1 and activates NF-κB through its N-terminal fragment
JJ Chae, G Wood, K Richard, H Jaffe, NT Colburn, SL Masters, ...
Blood, The Journal of the American Society of Hematology 112 (5), 1794-1803, 2008
1612008
Additive loss-of-function proteasome subunit mutations in CANDLE/PRAAS patients promote type I IFN production
A Brehm, Y Liu, A Sheikh, B Marrero, E Omoyinmi, Q Zhou, ...
The Journal of clinical investigation 125 (11), 4196-4211, 2015
1532015
Biallelic hypomorphic mutations in a linear deubiquitinase define otulipenia, an early-onset autoinflammatory disease
Q Zhou, X Yu, E Demirkaya, N Deuitch, D Stone, WL Tsai, HS Kuehn, ...
Proceedings of the National Academy of Sciences 113 (36), 10127-10132, 2016
1142016
Prostaglandin E2 inhibits NLRP3 inflammasome activation through EP4 receptor and intracellular cyclic AMP in human macrophages
M Sokolowska, LY Chen, Y Liu, A Martinez-Anton, HY Qi, C Logun, ...
The Journal of Immunology 194 (11), 5472-5487, 2015
1062015
Sexual dimorphism in immune response genes as a function of puberty
R Lamason, P Zhao, R Rawat, A Davis, JC Hall, JJ Chae, R Agarwal, ...
BMC immunology 7 (1), 2, 2006
972006
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