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Alfonso De Simone
Alfonso De Simone
Professor at University of Naples Federico II
Bestätigte E-Mail-Adresse bei unina.it - Startseite
Titel
Zitiert von
Zitiert von
Jahr
Atomic structure and hierarchical assembly of a cross-β amyloid fibril
AWP Fitzpatrick, GT Debelouchina, MJ Bayro, DK Clare, MA Caporini, ...
Proceedings of the National Academy of Sciences 110 (14), 5468-5473, 2013
6242013
Amyloid β protein and Alzheimer’s disease: When computer simulations complement experimental studies
J Nasica-Labouze, PH Nguyen, F Sterpone, O Berthoumieu, NV Buchete, ...
Chemical reviews 115 (9), 3518-3563, 2015
5902015
Structural basis of membrane disruption and cellular toxicity by α-synuclein oligomers
G Fusco, SW Chen, PTF Williamson, R Cascella, M Perni, JA Jarvis, ...
Science 358 (6369), 1440-1443, 2017
5402017
Release of High-Energy Water as an Essential Driving Force for the High-Affinity Binding of Cucurbit[n]urils
F Biedermann, VD Uzunova, OA Scherman, WM Nau, A De Simone
Journal of the American Chemical Society 134 (37), 15318-15323, 2012
5022012
Direct observation of the three regions in α-synuclein that determine its membrane-bound behaviour
G Fusco, A De Simone, T Gopinath, V Vostrikov, M Vendruscolo, ...
Nature communications 5 (1), 3827, 2014
4312014
Amyloid oligomers: A joint experimental/computational perspective on Alzheimer’s disease, Parkinson’s disease, type II diabetes, and amyotrophic lateral sclerosis
PH Nguyen, A Ramamoorthy, BR Sahoo, J Zheng, P Faller, JE Straub, ...
Chemical reviews 121 (4), 2545-2647, 2021
3992021
Determination of secondary structure populations in disordered states of proteins using nuclear magnetic resonance chemical shifts
C Camilloni, A De Simone, WF Vranken, M Vendruscolo
Biochemistry 51 (11), 2224-2231, 2012
3632012
C-terminal calcium binding of α-synuclein modulates synaptic vesicle interaction
J Lautenschläger, AD Stephens, G Fusco, F Ströhl, N Curry, ...
Nature communications 9 (1), 712, 2018
2552018
Structural basis of synaptic vesicle assembly promoted by α-synuclein
G Fusco, T Pape, AD Stephens, P Mahou, AR Costa, CF Kaminski, ...
Nature communications 7 (1), 12563, 2016
2302016
Cucurbit [8] uril and blue-box: high-energy water release overwhelms electrostatic interactions
F Biedermann, M Vendruscolo, OA Scherman, A De Simone, WM Nau
Journal of the American Chemical Society 135 (39), 14879-14888, 2013
1852013
Prion and water: tight and dynamical hydration sites have a key role in structural stability
A De Simone, GG Dodson, CS Verma, A Zagari, F Fraternali
Proceedings of the National Academy of Sciences 102 (21), 7535-7540, 2005
1772005
The inverted free energy landscape of an intrinsically disordered peptide by simulations and experiments
D Granata, F Baftizadeh, J Habchi, C Galvagnion, A De Simone, ...
Scientific reports 5 (1), 15449, 2015
1322015
Intrinsic disorder modulates protein self-assembly and aggregation
A De Simone, C Kitchen, AH Kwan, M Sunde, CM Dobson, D Frenkel
Proceedings of the National Academy of Sciences 109 (18), 6951-6956, 2012
1242012
Accurate random coil chemical shifts from an analysis of loop regions in native states of proteins
A De Simone, A Cavalli, STD Hsu, W Vranken, M Vendruscolo
Journal of the American Chemical Society 131 (45), 16332-16333, 2009
1152009
Josephin domain of ataxin‐3 contains two distinct ubiquitin‐binding sites
G Nicastro, L Masino, V Esposito, RP Menon, A De Simone, F Fraternali, ...
Biopolymers: Original Research on Biomolecules 91 (12), 1203-1214, 2009
1022009
Characterization of the conformational equilibrium between the two major substates of RNase A using NMR chemical shifts
C Camilloni, P Robustelli, AD Simone, A Cavalli, M Vendruscolo
Journal of the American Chemical Society 134 (9), 3968-3971, 2012
1002012
Extent of N-terminus exposure of monomeric alpha-synuclein determines its aggregation propensity
AD Stephens, M Zacharopoulou, R Moons, G Fusco, N Seetaloo, A Chiki, ...
Nature communications 11 (1), 2820, 2020
992020
Structural and hydration properties of the partially unfolded states of the prion protein
A De Simone, A Zagari, P Derreumaux
Biophysical journal 93 (4), 1284-1292, 2007
962007
Structural ensembles of membrane-bound α-synuclein reveal the molecular determinants of synaptic vesicle affinity
G Fusco, A De Simone, P Arosio, M Vendruscolo, G Veglia, CM Dobson
Scientific reports 6 (1), 27125, 2016
902016
Small-molecule sequestration of amyloid-β as a drug discovery strategy for Alzheimer’s disease
GT Heller, FA Aprile, TCT Michaels, R Limbocker, M Perni, FS Ruggeri, ...
Science Advances 6 (45), eabb5924, 2020
892020
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