フォロー
Ikuo Miyahisa
Ikuo Miyahisa
Takeda Pharmaceutical Co.
確認したメール アドレス: takeda.com
タイトル
引用先
引用先
Synthesis of unnatural flavonoids and stilbenes by exploiting the plant biosynthetic pathway in Escherichia coli
Y Katsuyama, N Funa, I Miyahisa, S Horinouchi
Chemistry & biology 14 (6), 613-621, 2007
2722007
Efficient production of (2S)-flavanones by Escherichia coli containing an artificial biosynthetic gene cluster
I Miyahisa, M Kaneko, N Funa, H Kawasaki, H Kojima, Y Ohnishi, ...
Applied microbiology and biotechnology 68, 498-504, 2005
2272005
Combinatorial biosynthesis of flavones and flavonols in Escherichia coli
I Miyahisa, N Funa, Y Ohnishi, S Martens, T Moriguchi, S Horinouchi
Applied microbiology and biotechnology 71, 53-58, 2006
1982006
Discovery of potent Mcl-1/Bcl-xL dual inhibitors by using a hybridization strategy based on structural analysis of target proteins
Y Tanaka, K Aikawa, G Nishida, M Homma, S Sogabe, S Igaki, Y Hayano, ...
Journal of medicinal chemistry 56 (23), 9635-9645, 2013
1282013
One-pot synthesis of genistein from tyrosine by coincubation of genetically engineered Escherichia coli and Saccharomyces cerevisiae cells
Y Katsuyama, I Miyahisa, N Funa, S Horinouchi
Applied microbiology and biotechnology 73, 1143-1149, 2007
872007
A Single Target Is Sufficient To Account for the Biological Effects of the A-Factor Receptor Protein of Streptomyces griseus
J Kato, I Miyahisa, M Mashiko, Y Ohnishi, S Horinouchi
Journal of bacteriology 186 (7), 2206-2211, 2004
552004
Rapid Determination of the Specificity Constant of Irreversible Inhibitors (kinact /KI) by Means of an Endpoint Competition Assay
Ikuo Miyahisa, Tomoya Sameshima, Mark S Hixon
Angewandte Chemie International Edition 54 (47), 14099–14102, 2015
54*2015
A novel selective inhibitor of delta-5 desaturase lowers insulin resistance and reduces body weight in diet-induced obese C57BL/6J mice
H Yashiro, S Takagahara, YO Tamura, I Miyahisa, J Matsui, H Suzuki, ...
PLoS One 11 (11), e0166198, 2016
402016
Discovery of novel and potent stearoyl coenzyme a desaturase 1 (SCD1) inhibitors as anticancer agents
K Imamura, N Tomita, Y Kawakita, Y Ito, K Ono, N Nii, T Miyazaki, ...
Bioorganic & medicinal chemistry 25 (14), 3768-3779, 2017
392017
Discovery of an irreversible and cell-active BCL6 inhibitor selectively targeting Cys53 located at the protein–protein interaction interface
T Sameshima, T Yamamoto, O Sano, S Sogabe, S Igaki, K Sakamoto, ...
Biochemistry 57 (8), 1369-1379, 2018
272018
In vitro and in vivo antitumor activities of T-3764518, a novel and orally available small molecule stearoyl-CoA desaturase 1 inhibitor
S Nishizawa, H Sumi, Y Satoh, Y Yamamoto, S Kitazawa, K Honda, ...
European journal of pharmacology 807, 21-31, 2017
232017
Discovery of 3, 5-diphenyl-4-methyl-1, 3-oxazolidin-2-ones as novel, potent, and orally available Δ-5 desaturase (D5D) inhibitors
J Fujimoto, R Okamoto, N Noguchi, R Hara, S Masada, T Kawamoto, ...
Journal of Medicinal Chemistry 60 (21), 8963-8981, 2017
212017
Structure-based rational design of staurosporine-based fluorescent probe with broad-ranging kinase affinity for kinase panel application
Y Hirozane, M Toyofuku, T Yogo, Y Tanaka, T Sameshima, I Miyahisa, ...
Bioorganic & medicinal chemistry letters 29 (21), 126641, 2019
172019
T-3364366 Targets the Desaturase Domain of Delta-5 Desaturase with Nanomolar Potency and a Multihour Residence Time
I Miyahisa, H Suzuki, A Mizukami, Y Tanaka, M Ono, MS Hixon, J Matsui
ACS Medicinal Chemistry Letters 7 (9), 868-872, 2016
172016
Small-scale panel comprising diverse gene family targets to evaluate compound promiscuity
T Sameshima, T Yukawa, Y Hirozane, M Yoshikawa, T Katoh, H Hara, ...
Chemical Research in Toxicology 33 (1), 154-161, 2019
132019
High-throughput quantitative intrinsic thiol reactivity evaluation using a fluorescence-based competitive endpoint assay
T Sameshima, I Miyahisa, S Yamasaki, M Gotou, T Kobayashi, ...
SLAS DISCOVERY: Advancing Life Sciences R&D 22 (9), 1168-1174, 2017
132017
Discovery and characterization of a small‐molecule enteropeptidase inhibitor, SCO‐792
M Sasaki, I Miyahisa, S Itono, H Yashiro, H Hiyoshi, K Tsuchimori, ...
Pharmacology research & perspectives 7 (5), e00517, 2019
122019
Universal and quantitative method to evaluate inhibitor potency for cysteinome proteins using a nonspecific activity-based protein profiling probe
T Sameshima, Y Tanaka, I Miyahisa
Biochemistry 56 (23), 2921-2927, 2017
52017
A simple and widely applicable hit validation strategy for protein-protein interaction inhibitors based on a quantitative ligand displacement assay
T Sameshima, I Miyahisa, M Homma, K Aikawa, MS Hixon, J Matsui
Bioorganic & Medicinal Chemistry Letters, 2014
22014
Asymmetric and Regiospecific Synthesis of Isotopically Labelled Cyclopropane Fatty Acid (9R, 10S)-Dihydrosterculic Acid: Overcoming Spontaneous Protonation During Lithium …
SWJ Shields, PH Buist, JM Manthorpe
SynOpen 2 (02), 0168-0175, 2018
12018
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