Mechanisms of action of Bcl-2 family proteins A Shamas-Din, J Kale, B Leber, DW Andrews Cold Spring Harbor perspectives in biology 5 (4), a008714, 2013 | 853 | 2013 |
Membrane binding by tBid initiates an ordered series of events culminating in membrane permeabilization by Bax JF Lovell, LP Billen, S Bindner, A Shamas-Din, C Fradin, B Leber, ... Cell 135 (6), 1074-1084, 2008 | 692 | 2008 |
BH3-only proteins: Orchestrators of apoptosis A Shamas-Din, H Brahmbhatt, B Leber, DW Andrews Biochimica et Biophysica Acta (BBA)-Molecular Cell Research 1813 (4), 508-520, 2011 | 504 | 2011 |
Bid: a Bax-like BH3 protein LP Billen, A Shamas-Din, DW Andrews Oncogene 27 (1), S93-S104, 2008 | 371 | 2008 |
tBid undergoes multiple conformational changes at the membrane required for Bax activation A Shamas-Din, S Bindner, W Zhu, Y Zaltsman, C Campbell, A Gross, ... Journal of Biological Chemistry 288 (30), 22111-22127, 2013 | 109 | 2013 |
Leveraging increased cytoplasmic nucleoside kinase activity to target mtDNA and oxidative phosphorylation in AML SU Liyanage, R Hurren, V Voisin, G Bridon, X Wang, CJ Xu, N MacLean, ... Blood, The Journal of the American Society of Hematology 129 (19), 2657-2666, 2017 | 79 | 2017 |
A Phase 1 study of intravenous infusions of tigecycline in patients with acute myeloid leukemia GA Reed, GJ Schiller, S Kambhampati, MS Tallman, D Douer, MD Minden, ... Cancer medicine 5 (11), 3031-3040, 2016 | 64 | 2016 |
Distinct lipid effects on tBid and Bim activation of membrane permeabilization by pro-apoptotic Bax A Shamas-Din, S Bindner, X Chi, B Leber, DW Andrews, C Fradin Biochemical Journal 467 (3), 495-505, 2015 | 61 | 2015 |
A phase I study of elesclomol sodium in patients with acute myeloid leukemia D Hedley, A Shamas-Din, S Chow, D Sanfelice, AC Schuh, JM Brandwein, ... Leukemia & lymphoma 57 (10), 2437-2440, 2016 | 53 | 2016 |
Multiple partners can kiss-and-run: Bax transfers between multiple membranes and permeabilizes those primed by tBid A Shamas-Din, D Satsoura, O Khan, W Zhu, B Leber, C Fradin, ... Cell death & disease 5 (6), e1277-e1277, 2014 | 44 | 2014 |
Allosteric regulation of BH3 proteins in Bcl-xL complexes enables switch-like activation of Bax C Bogner, J Kale, J Pogmore, X Chi, A Shamas-Din, C Fradin, B Leber, ... Molecular Cell 77 (4), 901-912. e9, 2020 | 36 | 2020 |
The proapoptotic protein tBid forms both superficially bound and membrane-inserted oligomers S Shivakumar, M Kurylowicz, N Hirmiz, Y Manan, O Friaa, A Shamas-Din, ... Biophysical journal 106 (10), 2085-2095, 2014 | 27 | 2014 |
A novel isoflavone, ME-344, targets the cytoskeleton in acute myeloid leukemia DV Jeyaraju, R Hurren, X Wang, N MacLean, M Gronda, A Shamas-Din, ... Oncotarget 7 (31), 49777, 2016 | 22 | 2016 |
Drug discovery in academia A Shamas-Din, AD Schimmer Experimental Hematology 43 (8), 713-717, 2015 | 19 | 2015 |
Characterizing the mitochondrial DNA polymerase gamma interactome by BioID identifies Ruvbl2 localizes to the mitochondria SU Liyanage, E Coyaud, EMN Laurent, R Hurren, N Maclean, SR Wood, ... Mitochondrion 32, 31-35, 2017 | 17 | 2017 |
Increased pressure alters plasma membrane dynamics and renders acute myeloid leukemia cells resistant to daunorubicin VS Nirmalanandhan, R Hurren, WD Cameron, M Gronda, A Shamas-Din, ... Haematologica 100 (10), e406, 2015 | 9 | 2015 |
Optimizing the Acquisition and Analysis of Confocal Images for Quantitative Single‐Mobile‐Particle Detection O Friaa, M Furukawa, A Shamas‐Din, B Leber, DW Andrews, C Fradin ChemPhysChem 14 (11), 2476-2490, 2013 | 6 | 2013 |
FV-162 is a novel, orally bioavailable, irreversible proteasome inhibitor with improved pharmacokinetics displaying preclinical efficacy with continuous daily dosing Z Wang, P Dove, X Wang, A Shamas-Din, Z Li, A Nachman, YJ Oh, ... Cell death & disease 6 (7), e1815-e1815, 2015 | 4 | 2015 |
The highly potent bromodomain (BRD) inhibitor FV-281 displays preclinical efficacy in acute myeloid leukemia (AML) Z Wang, P Dove, A Shamas-Din, R Hurren, X Wang, N MacLean, ... Blood, The Journal of the American Society of Hematology 126 (23), 1364-1364, 2015 | 1 | 2015 |
Binding and oligomerization of bcl-2 family proteins on supported lipid bilayers with single molecule resolution M Kurylowicz, S Shivakumar, A Shamas-Din, B Leber, DW Andrews, ... Biophysical Journal 104 (2), 222a, 2013 | 1 | 2013 |