| CellProfiler: image analysis software for identifying and quantifying cell phenotypes AE Carpenter, TR Jones, MR Lamprecht, C Clarke, IH Kang, O Friman, ... Genome biology 7 (10), 1-11, 2006 | 3875 | 2006 |
| A lentiviral RNAi library for human and mouse genes applied to an arrayed viral high-content screen J Moffat, DA Grueneberg, X Yang, SY Kim, AM Kloepfer, G Hinkle, ... Cell 124 (6), 1283-1298, 2006 | 1672 | 2006 |
| Ablation in mice of the mTORC components raptor, rictor, or mLST8 reveals that mTORC2 is required for signaling to Akt-FOXO and PKCα, but not S6K1 DA Guertin, DM Stevens, CC Thoreen, AA Burds, NY Kalaany, J Moffat, ... Developmental cell 11 (6), 859-871, 2006 | 1519 | 2006 |
| Mechanism of inhibition of protein-tyrosine phosphatases by vanadate and pervanadate G Huyer, S Liu, J Kelly, J Moffat, P Payette, B Kennedy, G Tsaprailis, ... Journal of Biological Chemistry 272 (2), 843-851, 1997 | 888 | 1997 |
| High-resolution CRISPR screens reveal fitness genes and genotype-specific cancer liabilities T Hart, M Chandrashekhar, M Aregger, Z Steinhart, KR Brown, ... Cell 163 (6), 1515-1526, 2015 | 884 | 2015 |
| Exploration of essential gene functions via titratable promoter alleles S Mnaimneh, AP Davierwala, J Haynes, J Moffat, WT Peng, W Zhang, ... Cell 118 (1), 31-44, 2004 | 633 | 2004 |
| Inhibition of mitochondrial translation as a therapeutic strategy for human acute myeloid leukemia M Škrtić, S Sriskanthadevan, B Jhas, M Gebbia, X Wang, Z Wang, ... Cancer cell 20 (5), 674-688, 2011 | 429 | 2011 |
| Dissecting DNA damage response pathways by analysing protein localization and abundance changes during DNA replication stress JM Tkach, A Yimit, AY Lee, M Riffle, M Costanzo, D Jaschob, JA Hendry, ... Nature cell biology 14 (9), 966-976, 2012 | 401 | 2012 |
| Scoring diverse cellular morphologies in image-based screens with iterative feedback and machine learning TR Jones, AE Carpenter, MR Lamprecht, J Moffat, SJ Silver, JK Grenier, ... Proceedings of the National Academy of Sciences 106 (6), 1826-1831, 2009 | 369 | 2009 |
| A dynamic protein interaction landscape of the human centrosome-cilium interface GD Gupta, É Coyaud, J Gonçalves, BA Mojarad, Y Liu, Q Wu, ... Cell 163 (6), 1484-1499, 2015 | 330 | 2015 |
| Essential gene profiles in breast, pancreatic, and ovarian cancer cells R Marcotte, KR Brown, F Suarez, A Sayad, K Karamboulas, ... Cancer discovery 2 (2), 172-189, 2012 | 292 | 2012 |
| Functional genomic landscape of human breast cancer drivers, vulnerabilities, and resistance R Marcotte, A Sayad, KR Brown, F Sanchez-Garcia, J Reimand, M Haider, ... Cell 164 (1-2), 293-309, 2016 | 264 | 2016 |
| MBNL proteins repress ES-cell-specific alternative splicing and reprogramming H Han, M Irimia, PJ Ross, HK Sung, B Alipanahi, L David, A Golipour, ... Nature 498 (7453), 241-245, 2013 | 262 | 2013 |
| Building mammalian signalling pathways with RNAi screens J Moffat, DM Sabatini Nature Reviews Molecular Cell Biology 7 (3), 177-187, 2006 | 254 | 2006 |
| Yeast proteome dynamics from single cell imaging and automated analysis YT Chong, JLY Koh, H Friesen, SK Duffy, MJ Cox, A Moses, J Moffat, ... Cell 161 (6), 1413-1424, 2015 | 231 | 2015 |
| Measuring error rates in genomic perturbation screens: gold standards for human functional genomics T Hart, KR Brown, F Sircoulomb, R Rottapel, J Moffat Molecular systems biology 10 (7), 733, 2014 | 222 | 2014 |
| A strategy for modulation of enzymes in the ubiquitin system A Ernst, G Avvakumov, J Tong, Y Fan, Y Zhao, P Alberts, A Persaud, ... Science 339 (6119), 590-595, 2013 | 216 | 2013 |
| The shieldin complex mediates 53BP1-dependent DNA repair SM Noordermeer, S Adam, D Setiaputra, M Barazas, SJ Pettitt, AK Ling, ... Nature 560 (7716), 117-121, 2018 | 201 | 2018 |
| Genome-wide CRISPR screens reveal a Wnt–FZD5 signaling circuit as a druggable vulnerability of RNF43-mutant pancreatic tumors Z Steinhart, Z Pavlovic, M Chandrashekhar, T Hart, X Wang, X Zhang, ... Nature medicine 23 (1), 60-68, 2017 | 184 | 2017 |
| Evaluation and design of genome-wide CRISPR/SpCas9 knockout screens T Hart, AHY Tong, K Chan, J Van Leeuwen, A Seetharaman, M Aregger, ... G3: Genes, Genomes, Genetics 7 (8), 2719-2727, 2017 | 178 | 2017 |
Kevin R BrownUniversity of TorontoVerified email at utoronto.ca
