Javier Iglesias-Fernández
Javier Iglesias-Fernández
Nostrum Biodiscovery - NBD
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Cited by
Cited by
Privateer: software for the conformational validation of carbohydrate structures
J Agirre, J Iglesias-Fernández, C Rovira, GJ Davies, KS Wilson, ...
Nature structural & molecular biology 22 (11), 833-834, 2015
Role of conformational dynamics in the evolution of novel enzyme function
MA Maria-Solano, E Serrano-Hervás, A Romero-Rivera, ...
Chemical Communications 54 (50), 6622-6634, 2018
Catalytic itinerary in 1, 3-1, 4-β-glucanase unraveled by QM/MM metadynamics. Charge is not yet fully developed at the oxocarbenium ion-like transition state
X Biarnés, A Ardèvol, J Iglesias-Fernández, A Planas, C Rovira
Journal of the American Chemical Society 133 (50), 20301-20309, 2011
Dynamic interplay between catalytic and lectin domains of GalNAc-transferases modulates protein O-glycosylation
E Lira-Navarrete, M de Las Rivas, I Compañón, MC Pallarés, Y Kong, ...
Nature communications 6 (1), 6937, 2015
Substrate‐Guided Front‐Face Reaction Revealed by Combined Structural Snapshots and Metadynamics for the Polypeptide N‐Acetylgalactosaminyltransferase 2
E Lira‐Navarrete, J Iglesias‐Fernández, WF Zandberg, I Compañón, ...
Angewandte Chemie 126 (31), 8345-8349, 2014
Enzyme conformation influences the performance of lipase‐powered nanomotors
L Wang, M Marciello, M Estévez‐Gay, PED Soto Rodriguez, ...
Angewandte Chemie 132 (47), 21266-21273, 2020
The Reaction Coordinate of a Bacterial GH47 α‐Mannosidase: A Combined Quantum Mechanical and Structural Approach
AJ Thompson, J Dabin, J Iglesias‐Fernández, A Ardèvol, Z Dinev, ...
Angewandte Chemie 124 (44), 11159-11163, 2012
Deciphering the allosterically driven conformational ensemble in tryptophan synthase evolution
MA Maria-Solano, J Iglesias-Fernández, S Osuna
Journal of the American Chemical Society 141 (33), 13049-13056, 2019
The reaction mechanism of retaining glycosyltransferases
A Ardevol, J Iglesias-Fernandez, V Rojas-Cervellera, C Rovira
Biochemical Society Transactions 44 (1), 51-60, 2016
The complete conformational free energy landscape of β-xylose reveals a two-fold catalytic itinerary for β-xylanases
J Iglesias-Fernández, L Raich, A Ardèvol, C Rovira
Chemical science 6 (2), 1167-1177, 2015
Evidence for a Boat Conformation at the Transition State of GH76 α‐1, 6‐Mannanases—Key Enzymes in Bacterial and Fungal Mannoprotein Metabolism
AJ Thompson, G Speciale, J Iglesias‐Fernández, Z Hakki, T Belz, ...
Angewandte Chemie International Edition 54 (18), 5378-5382, 2015
Combined inhibitor free‐energy landscape and structural analysis reports on the mannosidase conformational coordinate
RJ Williams, J Iglesias‐Fernández, J Stepper, A Jackson, AJ Thompson, ...
Angewandte Chemie 126 (4), 1105-1109, 2014
In Silico Identification and Experimental Validation of Distal Activity-Enhancing Mutations in Tryptophan Synthase
MA Maria-Solano, T Kinateder, J Iglesias-Fernández, R Sterner, S Osuna
ACS catalysis 11 (21), 13733-13743, 2021
Palladium-mediated enzyme activation suggests multiphase initiation of glycogenesis
MK Bilyard, HJ Bailey, L Raich, MA Gafitescu, T Machida, ...
Nature 563 (7730), 235-240, 2018
A front-face 'SNi synthase' engineered from a retaining 'double-SN2' hydrolase
J Iglesias-Fernández, SM Hancock, SS Lee, M Khan, J Kirkpatrick, ...
Nature Chemical Biology 13 (8), 874-881, 2017
Hidden Conformations in Aspergillus niger Monoamine Oxidase are Key for Catalytic Efficiency
C Curado‐Carballada, F Feixas, J Iglesias‐Fernández, S Osuna
Angewandte Chemie International Edition 58 (10), 3097-3101, 2019
A single glycosidase harnesses different pyranoside ring transition state conformations for hydrolysis of mannosides and glucosides
A Tankrathok, J Iglesias-Fernandez, RJ Williams, S Pengthaisong, ...
ACS Catalysis 5 (10), 6041-6051, 2015
Molecular dynamics simulations and neutron reflectivity as an effective approach to characterize biological membranes and related macromolecular assemblies
L Darré, J Iglesias-Fernandez, A Kohlmeyer, H Wacklin, C Domene
Journal of Chemical Theory and Computation 11 (10), 4875-4884, 2015
Enantioselective Preparation of δ‐Valerolactones with Horse Liver Alcohol Dehydrogenase
A Díaz‐Rodríguez, J Iglesias‐Fernández, C Rovira, V Gotor‐Fernández
ChemCatChem 6 (4), 977-980, 2014
Surfactin at the water/air interface and in solution
J Iglesias-Fernandez, L Darre, A Kohlmeyer, RK Thomas, HH Shen, ...
Langmuir 31 (40), 11097-11104, 2015
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