Calcium-independent phospholipases A2 and their roles in biological processes and diseases S Ramanadham, T Ali, JW Ashley, RN Bone, WD Hancock, X Lei Journal of lipid research 56 (9), 1643-1668, 2015 | 198 | 2015 |
Endoplasmic reticulum stress alters ryanodine receptor function in the murine pancreatic β cell WR Yamamoto, RN Bone, P Sohn, F Syed, CA Reissaus, AL Mosley, ... Journal of Biological Chemistry 294 (1), 168-181, 2019 | 101 | 2019 |
Regeneration of pancreatic non-β endocrine cells in adult mice following a single diabetes-inducing dose of streptozotocin Y Zhang, Y Zhang, RN Bone, W Cui, JB Peng, GP Siegal, H Wang, H Wu PloS one 7 (5), e36675, 2012 | 77 | 2012 |
Impaired store-operated calcium entry and STIM1 loss lead to reduced insulin secretion and increased endoplasmic reticulum stress in the diabetic β-cell T Kono, X Tong, S Taleb, RN Bone, H Iida, CC Lee, P Sohn, P Gilon, ... Diabetes 67 (11), 2293-2304, 2018 | 61 | 2018 |
Polarization of macrophages toward M2 phenotype is favored by reduction in iPLA2β (group VIA phospholipase A2) JW Ashley, WD Hancock, AJ Nelson, RN Bone, MT Hubert, M Wohltmann, ... Journal of Biological Chemistry 291 (44), 23268-23281, 2016 | 47 | 2016 |
Inhibition of Ca2+-Independent Phospholipase A2β (iPLA2β) Ameliorates Islet Infiltration and Incidence of Diabetes in NOD Mice RN Bone, Y Gai, V Magrioti, MG Kokotou, T Ali, X Lei, HM Tse, G Kokotos, ... Diabetes 64 (2), 541-554, 2015 | 46 | 2015 |
Characterization of FKGK18 as Inhibitor of Group VIA Ca2+-Independent Phospholipase A2 (iPLA2β): Candidate Drug for Preventing Beta-Cell Apoptosis and … T Ali, G Kokotos, V Magrioti, RN Bone, JA Mobley, W Hancock, ... PloS one 8 (8), e71748, 2013 | 44 | 2013 |
Combination immunotherapy for type 1 diabetes RN Bone, C Evans-Molina Current diabetes reports 17 (7), 50, 2017 | 40 | 2017 |
Genetic modulation of islet β-cell iPLA2β expression provides evidence for its impact on β-cell apoptosis and autophagy X Lei, RN Bone, T Ali, M Wohltmann, Y Gai, KJ Goodwin, AE Bohrer, ... Islets 5 (1), 29-44, 2013 | 36 | 2013 |
Evidence of Contribution of iPLA2β-Mediated Events During Islet β-Cell Apoptosis Due to Proinflammatory Cytokines Suggests a Role for iPLA2β in T1D … X Lei, RN Bone, T Ali, S Zhang, A Bohrer, HM Tse, KR Bidasee, ... Endocrinology 155 (9), 3352-3364, 2014 | 32 | 2014 |
Cigarette smoke exposure impairs β-cell function through activation of oxidative stress and ceramide accumulation X Tong, Z Chaudhry, CC Lee, RN Bone, S Kanojia, J Maddatu, P Sohn, ... Molecular Metabolism 37, 100975, 2020 | 27 | 2020 |
A computational approach for defining a signature of β-cell Golgi stress in diabetes RN Bone, O Oyebamiji, S Talware, S Selvaraj, P Krishnan, F Syed, H Wu, ... Diabetes 69 (11), 2364-2376, 2020 | 26 | 2020 |
Gene transfer of active Akt1 by an infectivity-enhanced adenovirus impacts β-cell survival and proliferation differentially in vitro and in vivo RN Bone, M Icyuz, Y Zhang, Y Zhang, W Cui, H Wang, JB Peng, ... Islets 4 (6), 366-378, 2012 | 25 | 2012 |
Lipid mediators and biomarkers associated with type 1 diabetes development AJ Nelson, DJ Stephenson, RN Bone, CL Cardona, MA Park, YG Tusing, ... JCI insight 5 (16), 2020 | 19 | 2020 |
Offspring of obese dams exhibit sex-differences in pancreatic heparan sulfate glycosaminoglycans and islet insulin secretion J Casasnovas, CL Damron, J Jarrell, KS Orr, RN Bone, ... Frontiers in Endocrinology 12, 658439, 2021 | 12 | 2021 |
A high-fat diet catalyzes progression to hyperglycemia in mice with selective impairment of insulin action in Glut4-expressing tissues AM Reilly, S Yan, M Huang, SD Abhyankar, JM Conley, RN Bone, ... Journal of Biological Chemistry 298 (1), 2022 | 11 | 2022 |
A discovery-based proteomics approach identifies protein disulphide isomerase (PDIA1) as a biomarker of β cell stress in type 1 diabetes F Syed, D Singhal, K Raedschelders, P Krishnan, RN Bone, ... EBioMedicine 87, 2023 | 8 | 2023 |
Nmp4, a regulator of induced osteoanabolism, also influences insulin secretion and sensitivity J Bidwell, SA Tersey, M Adaway, RN Bone, A Creecy, A Klunk, ... Calcified tissue international 110 (2), 244-259, 2022 | 4 | 2022 |
SERCA2 regulates proinsulin processing and processing enzyme maturation in pancreatic beta cells H Iida, T Kono, CC Lee, P Krishnan, MC Arvin, SA Weaver, TS Jarvela, ... Diabetologia 66 (11), 2042-2061, 2023 | 3 | 2023 |
Reduced ß cell SPCA1 leads to impaired calcium oscillations and decreased autophagy RN Bone, T Kono, C Evans-Molina Diabetes 67 (Supplement_1), 2018 | 2 | 2018 |