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Irina Alecu
Irina Alecu
Verified email at uottawa.ca
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Year
Dysregulated lipid metabolism and its role in α-synucleinopathy in Parkinson’s disease
I Alecu, SAL Bennett
Frontiers in neuroscience 13, 444188, 2019
1982019
1-Deoxysphingolipids
HT Lone M, Santos T, Alecu I, Silva L
Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, 2019
842019
HSAN1 mutations in serine palmitoyltransferase reveal a close structure–function–phenotype relationship
H Bode, F Bourquin, S Suriyanarayanan, Y Wei, I Alecu, A Othman, ...
Human molecular genetics 25 (5), 853-865, 2016
802016
Lowering plasma 1-deoxysphingolipids improves neuropathy in diabetic rats
A Othman, R Bianchi, I Alecu, Y Wei, C Porretta-Serapiglia, R Lombardi, ...
Diabetes 64 (3), 1035-1045, 2015
802015
Localization of 1-deoxysphingolipids to mitochondria induces mitochondrial dysfunction
I Alecu, A Tedeschi, N Behler, K Wunderling, C Lamberz, M Lauterbach, ...
Journal of Lipid Research, jlr.M068676, 2016
782016
Neurotoxic 1-deoxysphingolipids and paclitaxel-induced peripheral neuropathy
R Kramer, J Bielawski, E Kistner-Griffin, A Othman, I Alecu, D Ernst, ...
The FASEB Journal 29 (11), 4461-4472, 2015
782015
Cytotoxic 1-Deoxysphingolipids Are Metabolized by a Cytochrome P450-Dependent Pathway
I Alecu, A Othman, A Penno, E M. Saied, C Arenz, von Eckardstein Arnold, ...
Journal of Lipid Research, jlr.M072421, 2016
572016
Elevation of plasma 1‐deoxy‐sphingolipids in type 2 diabetes mellitus: a susceptibility to neuropathy?
MF Dohrn, A Othman, SK Hirshman, H Bode, I Alecu, E Fähndrich, ...
European journal of neurology 22 (5), 806-e55, 2015
562015
Altered sphingoid base profiles in type 1 compared to type 2 diabetes
N Wei, J Pan, R Pop-Busui, A Othman, I Alecu, T Hornemann, FS Eichler
Lipids in health and disease 13, 1-4, 2014
462014
Fenofibrate lowers atypical sphingolipids in plasma of dyslipidemic patients: A novel approach for treating diabetic neuropathy?
A Othman, R Benghozi, I Alecu, Y Wei, E Niesor, A von Eckardstein, ...
Journal of clinical lipidology 9 (4), 568-575, 2015
392015
ORMDL3 expression levels have no influence on the activity of serine palmitoyltransferase
A Zhakupova, N Debeuf, M Krols, W Toussaint, L Vanhoutte, I Alecu, ...
The FASEB Journal 30 (12), 4289-4300, 2016
312016
Farnesoid X receptor activation induces the degradation of hepatotoxic 1‐deoxysphingolipids in non‐alcoholic fatty liver disease
Z Gai, T Gui, I Alecu, MA Lone, T Hornemann, Q Chen, M Visentin, ...
Liver International 40 (4), 844-859, 2020
252020
Serine palmitoyltransferase assembles at ER–mitochondria contact sites
MJ Aaltonen, I Alecu, T König, SAL Bennett, EA Shoubridge
Life Science Alliance 5 (2), 2022
202022
Exercise training enhances muscle mitochondrial metabolism in diet-resistant obesity
MEH CA Pileggi, DP Blondin, BG Hooks, G Parmar, I Alecu, DA Patten, A ...
eBioMedicine, 2022
122022
Disturbed sphingolipid metabolism with elevated 1-deoxysphingolipids in glycogen storage disease type I – A link to metabolic control
T Hornemanna, I Alecu, N Hagenbuch, A Zhakupova, A Cremonesi, ...
Molecular Genetics and Metabolism, 2018
102018
1-deoxysphingolipids bind to COUP-TF to modulate lymphatic and cardiac cell development
T Wang, Z Wang, L de Fabritus, J Tao, EM Saied, HJ Lee, BR Ramazanov, ...
Developmental Cell 56 (22), 3128-3145. e15, 2021
92021
Oxidative stress increases 1-deoxysphingolipid levels in chronic kidney disease
ZG Ting Gui, Yunlun Li, Shijun Zhang, Irina Alecu, Qingfa Chen, Ying Zhao ...
Free Radical Biology and Medicine 164, 139-148, 2021
92021
Signed Distance Correlation (SiDCo): an online implementation of distance correlation and partial distance correlation for data-driven network analysis
F Monti, D Stewart, A Surendra, I Alecu, T Nguyen-Tran, SAL Bennett, ...
Bioinformatics 39 (5), btad210, 2023
62023
BATL: Bayesian annotations for targeted lipidomics.
PTJ Chitpin JG, Surendra A, Nguyen TT, Taylor GP, Xu H, Alecu I, Ortega R ...
Bioinformatics, 2021
4*2021
Plasma Sphingoid Base Profiles of Patients Diagnosed with Intrinsic or Idiosyncratic Drug-induced Liver Injury
Z Gai, SL Samodelov, I Alecu, T Hornemann, JI Grove, GP Aithal, ...
International Journal of Molecular Sciences 24 (3), 3013, 2023
32023
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