Rowan Higgs
Rowan Higgs
Postdoctoral Research Fellow, Trinity College Dublin
Verified email at
Cited by
Cited by
Bioinformatic discovery and initial characterisation of nine novel antimicrobial peptide genes in the chicken
DJ Lynn, R Higgs, S Gaines, J Tierney, T James, AT Lloyd, MA Fares, ...
Immunogenetics 56 (3), 170-177, 2004
The E3 ubiquitin ligase Ro52 negatively regulates IFN-β production post-pathogen recognition by polyubiquitin-mediated degradation of IRF3
R Higgs, JN Gabhann, NB Larbi, EP Breen, KA Fitzgerald, CA Jefferies
The Journal of Immunology 181 (3), 1780-1786, 2008
Loss of the lupus autoantigen Ro52/Trim21 induces tissue inflammation and systemic autoimmunity by disregulating the IL-23–Th17 pathway
A Espinosa, V Dardalhon, S Brauner, A Ambrosi, R Higgs, FJ Quintana, ...
Journal of experimental medicine 206 (8), 1661-1671, 2009
Immunity to the respiratory pathogen Bordetella pertussis
R Higgs, SC Higgins, PJ Ross, KHG Mills
Mucosal immunology 5 (5), 485-500, 2012
Retinoic acid expression associates with enhanced IL-22 production by γδ T cells and innate lymphoid cells and attenuation of intestinal inflammation
LA Mielke, SA Jones, M Raverdeau, R Higgs, A Stefanska, JR Groom, ...
Journal of Experimental Medicine 210 (6), 1117-1124, 2013
Induction of a novel chicken Toll-like receptor following Salmonella enterica serovar Typhimurium infection
R Higgs, P Cormican, S Cahalane, B Allan, AT Lloyd, K Meade, T James, ...
Infection and immunity 74 (3), 1692-1698, 2006
Avian beta-defensin nomenclature: a community proposed update
DJ Lynn, R Higgs, AT Lloyd, C O'Farrelly, V Hervé-Grépinet, Y Nys, ...
Immunology letters 110 (1), 86-89, 2007
The synthetic form of a novel chicken β-defensin identified in silico is predominantly active against intestinal pathogens
R Higgs, DJ Lynn, S Gaines, J McMahon, J Tierney, T James, AT Lloyd, ...
Immunogenetics 57 (1-2), 90-98, 2005
Self protection from anti-viral responses–Ro52 promotes degradation of the transcription factor IRF7 downstream of the viral Toll-Like receptors
R Higgs, E Lazzari, C Wynne, JN Gabhann, A Espinosa, ...
PloS one 5 (7), e11776, 2010
Antiviral TRIMs: friend or foe in autoimmune and autoinflammatory disease?
C Jefferies, C Wynne, R Higgs
Nature Reviews Immunology 11 (9), 617-625, 2011
Immunotherapy with PI3K inhibitor and Toll-like receptor agonist induces IFN-γ+ IL-17+ polyfunctional T cells that mediate rejection of murine tumors
NA Marshall, KC Galvin, AMB Corcoran, L Boon, R Higgs, KHG Mills
Cancer research 72 (3), 581-591, 2012
Differential antimicrobial peptide gene expression patterns during early chicken embryological development
KG Meade, R Higgs, AT Lloyd, S Giles, C O’Farrelly
Developmental & Comparative Immunology 33 (4), 516-524, 2009
Absence of SHIP-1 results in constitutive phosphorylation of tank-binding kinase 1 and enhanced TLR3-dependent IFN-β production
JN Gabhann, R Higgs, K Brennan, W Thomas, JE Damen, NB Larbi, ...
The Journal of Immunology 184 (5), 2314-2320, 2010
Modification of chicken avian β-defensin-8 at positively selected amino acid sites enhances specific antimicrobial activity
R Higgs, DJ Lynn, S Cahalane, I Alaña, CM Hewage, T James, AT Lloyd, ...
Immunogenetics 59 (7), 573-580, 2007
Enhanced interferon regulatory factor 3 binding to the interleukin‐23p19 promoter correlates with enhanced interleukin‐23 expression in systemic lupus erythematosus
S Smith, JN Gabhann, R Higgs, K Stacey, M Wahren‐Herlenius, ...
Arthritis & Rheumatism 64 (5), 1601-1609, 2012
Targeting IRFs by ubiquitination: regulating antiviral responses
R Higgs, CA Jefferies
Biochemical Society Transactions 36 (3), 453-458, 2008
In silico cloning of new antimicrobial peptides and Toll-like receptor pathway components in the chicken
D Lynn, R Higgs, S Gaines, T James, A Lloyd, J Tierney, G Mulcahy, ...
Tissue Antigens 64 (4), 333-334, 2004
The role of TRIM68 in Toll-like receptor and RIG-I-like receptor induced interferon production (72.5)
C Wynne, R Higgs, C Biron, C Jefferies
The Journal of Immunology 188 (1 Supplement), 72.5-72.5, 2012
Cancer-initiating cells identified in acute promyelocytic leukemia
R Higgs
Nature Reviews Clinical Oncology 7 (3), 124-124, 2010
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