| Naturally secreted oligomers of amyloid β protein potently inhibit hippocampal long-term potentiation in vivo DM Walsh, I Klyubin, JV Fadeeva, WK Cullen, R Anwyl, MS Wolfe, ... Nature 416 (6880), 535-539, 2002 | 5509 | 2002 |
| Amyloid-β protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory GM Shankar, S Li, TH Mehta, A Garcia-Munoz, NE Shepardson, I Smith, ... Nature medicine 14 (8), 837-842, 2008 | 4405 | 2008 |
| Aβ oligomers–a decade of discovery DM Walsh, DJ Selkoe Journal of neurochemistry 101 (5), 1172-1184, 2007 | 2532 | 2007 |
| Natural oligomers of the amyloid-β protein specifically disrupt cognitive function JP Cleary, DM Walsh, JJ Hofmeister, GM Shankar, MA Kuskowski, ... Nature neuroscience 8 (1), 79-84, 2005 | 2217 | 2005 |
| Deciphering the molecular basis of memory failure in Alzheimer's disease DM Walsh, DJ Selkoe Neuron 44 (1), 181-193, 2004 | 1572 | 2004 |
| Amyloid β-protein fibrillogenesis: structure and biological activity of protofibrillar intermediates DM Walsh, DM Hartley, Y Kusumoto, Y Fezoui, MM Condron, A Lomakin, ... Journal of Biological Chemistry 274 (36), 25945-25952, 1999 | 1423 | 1999 |
| Amyloid β-protein fibrillogenesis: detection of a protofibrillar intermediate DM Walsh, A Lomakin, GB Benedek, MM Condron, DB Teplow Journal of Biological Chemistry 272 (35), 22364-22372, 1997 | 1380 | 1997 |
| Protofibrillar intermediates of amyloid β-protein induce acute electrophysiological changes and progressive neurotoxicity in cortical neurons DM Hartley, DM Walsh, PY Chianping, T Diehl, S Vasquez, PM Vassilev, ... Journal of Neuroscience 19 (20), 8876-8884, 1999 | 1236 | 1999 |
| Soluble oligomers of amyloid β protein facilitate hippocampal long-term depression by disrupting neuronal glutamate uptake S Li, S Hong, NE Shepardson, DM Walsh, GM Shankar, D Selkoe Neuron 62 (6), 788-801, 2009 | 1155 | 2009 |
| Exogenous induction of cerebral ß-amyloidogenesis is governed by agent and host M Meyer-Luehmann, J Coomaraswamy, T Bolmont, S Kaeser, C Schaefer, ... Science 313 (5794), 1781-1784, 2006 | 1113 | 2006 |
| Soluble amyloid β-protein dimers isolated from Alzheimer cortex directly induce Tau hyperphosphorylation and neuritic degeneration M Jin, N Shepardson, T Yang, G Chen, D Walsh, DJ Selkoe Proceedings of the National Academy of Sciences 108 (14), 5819-5824, 2011 | 1088 | 2011 |
| Enhanced proteolysis of β-amyloid in APP transgenic mice prevents plaque formation, secondary pathology, and premature death MA Leissring, W Farris, AY Chang, DM Walsh, X Wu, X Sun, MP Frosch, ... Neuron 40 (6), 1087-1093, 2003 | 928 | 2003 |
| Effects of secreted oligomers of amyloid β‐protein on hippocampal synaptic plasticity: a potent role for trimers M Townsend, GM Shankar, T Mehta, DM Walsh, DJ Selkoe The Journal of physiology 572 (2), 477-492, 2006 | 819 | 2006 |
| Protein aggregation in the brain: the molecular basis for Alzheimer’s and Parkinson’s diseases GB Irvine, OM El-Agnaf, GM Shankar, DM Walsh Molecular medicine 14, 451-464, 2008 | 693 | 2008 |
| Amyloid β protein immunotherapy neutralizes Aβ oligomers that disrupt synaptic plasticity in vivo I Klyubin, DM Walsh, CA Lemere, WK Cullen, GM Shankar, V Betts, ... Nature medicine 11 (5), 556-561, 2005 | 688 | 2005 |
| The formation of highly soluble oligomers of α-synuclein is regulated by fatty acids and enhanced in Parkinson's disease R Sharon, I Bar-Joseph, MP Frosch, DM Walsh, JA Hamilton, DJ Selkoe Neuron 37 (4), 583-595, 2003 | 682 | 2003 |
| The oligomerization of amyloid β-protein begins intracellularly in cells derived from human brain DM Walsh, BP Tseng, RE Rydel, MB Podlisny, DJ Selkoe Biochemistry 39 (35), 10831-10839, 2000 | 647 | 2000 |
| Neurons regulate extracellular levels of amyloid β-protein via proteolysis by insulin-degrading enzyme K Vekrellis, Z Ye, WQ Qiu, D Walsh, D Hartley, V Chesneau, MR Rosner, ... Journal of Neuroscience 20 (5), 1657-1665, 2000 | 641 | 2000 |
| Alzheimer's disease: synaptic dysfunction and Aβ GM Shankar, DM Walsh Molecular neurodegeneration 4, 1-13, 2009 | 626 | 2009 |
| Block of long-term potentiation by naturally secreted and synthetic amyloid β-peptide in hippocampal slices is mediated via activation of the kinases c-Jun N-terminal kinase … Q Wang, DM Walsh, MJ Rowan, DJ Selkoe, R Anwyl Journal of Neuroscience 24 (13), 3370-3378, 2004 | 570 | 2004 |
