David M. Sabatini
David M. Sabatini
Whitehead Institute/MIT/HHMI
Verified email at wi.mit.edu - Homepage
TitleCited byYear
Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex
DD Sarbassov, DA Guertin, SM Ali, DM Sabatini
Science 307 (5712), 1098-1101, 2005
Guidelines for the use and interpretation of assays for monitoring autophagy
DJ Klionsky, K Abdelmohsen, A Abe, MJ Abedin, H Abeliovich, ...
Autophagy 12 (1), 1-222, 2016
mTOR signaling in growth control and disease
M Laplante, DM Sabatini
Cell 149 (2), 274-293, 2012
mTOR: from growth signal integration to cancer, diabetes and ageing
R Zoncu, A Efeyan, DM Sabatini
Nature reviews Molecular cell biology 12 (1), 21-35, 2011
CellProfiler: image analysis software for identifying and quantifying cell phenotypes
AE Carpenter, TR Jones, MR Lamprecht, C Clarke, IH Kang, O Friman, ...
Genome biology 7 (10), R100, 2006
Defining the role of mTOR in cancer
DA Guertin, DM Sabatini
Cancer cell 12 (1), 9-22, 2007
mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery
DH Kim, DD Sarbassov, SM Ali, JE King, RR Latek, ...
Cell 110 (2), 163-175, 2002
Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton
DD Sarbassov, SM Ali, DH Kim, DA Guertin, RR Latek, ...
Current biology 14 (14), 1296-1302, 2004
Prolonged rapamycin treatment inhibits mTORC2 assembly and Akt/PKB
DD Sarbassov, SM Ali, S Sengupta, JH Sheen, PP Hsu, AF Bagley, ...
Molecular cell 22 (2), 159-168, 2006
The Rag GTPases bind raptor and mediate amino acid signaling to mTORC1
Y Sancak, TR Peterson, YD Shaul, RA Lindquist, CC Thoreen, ...
Science 320 (5882), 1496-1501, 2008
mTOR signaling in growth, metabolism, and disease
RA Saxton, DM Sabatini
Cell 168 (6), 960-976, 2017
Genetic screens in human cells using the CRISPR-Cas9 system
T Wang, JJ Wei, DM Sabatini, ES Lander
Science 343 (6166), 80-84, 2014
Cancer cell metabolism: Warburg and beyond
PP Hsu, DM Sabatini
Cell 134 (5), 703-707, 2008
mTOR signaling at a glance
M Laplante, DM Sabatini
Journal of cell science 122 (20), 3589-3594, 2009
Ragulator-Rag complex targets mTORC1 to the lysosomal surface and is necessary for its activation by amino acids
Y Sancak, L Bar-Peled, R Zoncu, AL Markhard, S Nada, DM Sabatini
Cell 141 (2), 290-303, 2010
Growing roles for the mTOR pathway
DD Sarbassov, SM Ali, DM Sabatini
Current opinion in cell biology 17 (6), 596-603, 2005
A lentiviral RNAi library for human and mouse genes applied to an arrayed viral high-content screen
J Moffat, DA Grueneberg, X Yang, SY Kim, AM Kloepfer, G Hinkle, ...
Cell 124 (6), 1283-1298, 2006
RAFT1: a mammalian protein that binds to FKBP12 in a rapamycin-dependent fashion and is homologous to yeast TORs
DM Sabatini, H Erdjument-Bromage, M Lui, P Tempst, SH Snyder
Cell 78 (1), 35-43, 1994
An ATP-competitive mammalian target of rapamycin inhibitor reveals rapamycin-resistant functions of mTORC1
CC Thoreen, SA Kang, JW Chang, Q Liu, J Zhang, Y Gao, LJ Reichling, ...
Journal of Biological Chemistry 284 (12), 8023-8032, 2009
Ablation in mice of the mTORC components raptor, rictor, or mLST8 reveals that mTORC2 is required for signaling to Akt-FOXO and PKCα, but not S6K1
DA Guertin, DM Stevens, CC Thoreen, AA Burds, NY Kalaany, J Moffat, ...
Developmental cell 11 (6), 859-871, 2006
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