Dagmar Ehrnhoefer
Dagmar Ehrnhoefer
Principal Research Scientist, AbbVie GmbH Co KG, Germany
Verified email at
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EGCG redirects amyloidogenic polypeptides into unstructured, off-pathway oligomers
DE Ehrnhoefer, J Bieschke, A Boeddrich, M Herbst, L Masino, R Lurz, ...
Nature structural & molecular biology 15 (6), 558-566, 2008
EGCG remodels mature α-synuclein and amyloid-β fibrils and reduces cellular toxicity
J Bieschke, J Russ, RP Friedrich, DE Ehrnhoefer, H Wobst, ...
Proceedings of the National Academy of Sciences 107 (17), 7710-7715, 2010
Balance between synaptic versus extrasynaptic NMDA receptor activity influences inclusions and neurotoxicity of mutant huntingtin
S Okamoto, MA Pouladi, M Talantova, D Yao, P Xia, DE Ehrnhoefer, ...
Nature medicine 15 (12), 1407-1413, 2009
Green tea (−)-epigallocatechin-gallate modulates early events in huntingtin misfolding and reduces toxicity in Huntington's disease models
DE Ehrnhoefer, M Duennwald, P Markovic, JL Wacker, S Engemann, ...
Human molecular genetics 15 (18), 2743-2751, 2006
Autophagy in Huntington disease and huntingtin in autophagy
DDO Martin, S Ladha, DE Ehrnhoefer, MR Hayden
Trends in neurosciences 38 (1), 26-35, 2015
Small changes, big impact: posttranslational modifications and function of huntingtin in Huntington disease
DE Ehrnhoefer, L Sutton, MR Hayden
The Neuroscientist 17 (5), 475-492, 2011
Prevention of depressive behaviour in the YAC128 mouse model of Huntington disease by mutation at residue 586 of huntingtin
MA Pouladi, RK Graham, JM Karasinska, Y Xie, RD Santos, Å Petersén, ...
Brain 132 (4), 919-932, 2009
Caspase-6 and neurodegeneration
RK Graham, DE Ehrnhoefer, MR Hayden
Trends in neurosciences 34 (12), 646-656, 2011
Full-length huntingtin levels modulate body weight by influencing insulin-like growth factor 1 expression
MA Pouladi, Y Xie, NH Skotte, DE Ehrnhoefer, RK Graham, JE Kim, ...
Human molecular genetics 19 (8), 1528-1538, 2010
Mouse models of Huntington disease: variations on a theme
DE Ehrnhoefer, SL Butland, MA Pouladi, MR Hayden
Disease models & mechanisms 2 (3-4), 123-129, 2009
HACE1 reduces oxidative stress and mutant Huntingtin toxicity by promoting the NRF2 response
B Rotblat, AL Southwell, DE Ehrnhoefer, NH Skotte, M Metzler, ...
Proceedings of the National Academy of Sciences 111 (8), 3032-3037, 2014
Convergent pathogenic pathways in Alzheimer's and Huntington's diseases: shared targets for drug development
DE Ehrnhoefer, BKY Wong, MR Hayden
Nature reviews Drug discovery 10 (11), 853-867, 2011
A validated antibody panel for the characterization of tau post-translational modifications
E Ercan, S Eid, C Weber, A Kowalski, M Bichmann, A Behrendt, F Matthes, ...
Molecular neurodegeneration 12, 1-19, 2017
Rescue from excitotoxicity and axonal degeneration accompanied by age-dependent behavioral and neuroanatomical alterations in caspase-6-deficient mice
V Uribe, BKY Wong, RK Graham, CL Cusack, NH Skotte, MA Pouladi, ...
Human molecular genetics 21 (9), 1954-1967, 2012
A Huntingtin-based peptide inhibitor of caspase-6 provides protection from mutant Huntingtin-induced motor and behavioral deficits
I Aharony, DE Ehrnhoefer, A Shruster, X Qiu, S Franciosi, MR Hayden, ...
Human molecular genetics 24 (9), 2604-2614, 2015
A post-translational modification signature defines changes in soluble tau correlating with oligomerization in early stage Alzheimer’s disease brain
E Ercan-Herbst, J Ehrig, DC Schöndorf, A Behrendt, B Klaus, ...
Acta neuropathologica communications 7, 1-19, 2019
Partial rescue of some features of Huntington Disease in the genetic absence of caspase-6 in YAC128 mice
BKY Wong, DE Ehrnhoefer, RK Graham, DDO Martin, S Ladha, V Uribe, ...
Neurobiology of disease 76, 24-36, 2015
p53 increases caspase-6 expression and activation in muscle tissue expressing mutant huntingtin
DE Ehrnhoefer, NH Skotte, S Ladha, YTN Nguyen, X Qiu, Y Deng, ...
Human molecular genetics 23 (3), 717-729, 2014
Preventing mutant huntingtin proteolysis and intermittent fasting promote autophagy in models of Huntington disease
DE Ehrnhoefer, DDO Martin, ME Schmidt, X Qiu, S Ladha, NS Caron, ...
Acta neuropathologica communications 6, 1-16, 2018
NP03, a novel low-dose lithium formulation, is neuroprotective in the YAC128 mouse model of Huntington disease
MA Pouladi, E Brillaud, Y Xie, P Conforti, RK Graham, DE Ehrnhoefer, ...
Neurobiology of disease 48 (3), 282-289, 2012
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