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Christopher Jakobson
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Evidence for improved encapsulated pathway behavior in a bacterial microcompartment through shell protein engineering
MF Slininger Lee, CM Jakobson, D Tullman-Ercek
ACS synthetic biology 6 (10), 1880-1891, 2017
772017
Influence of electrostatics on small molecule flux through a protein nanoreactor
JE Glasgow, MA Asensio, CM Jakobson, MB Francis, D Tullman-Ercek
ACS synthetic biology 4 (9), 1011-1019, 2015
722015
Localization of proteins to the 1, 2-propanediol utilization microcompartment by non-native signal sequences is mediated by a common hydrophobic motif
CM Jakobson, EY Kim, MF Slininger, A Chien, D Tullman-Ercek
Journal of Biological Chemistry 290 (40), 24519-24533, 2015
642015
A systems-level model reveals that 1, 2-Propanediol utilization microcompartments enhance pathway flux through intermediate sequestration
CM Jakobson, D Tullman-Ercek, MF Slininger, NM Mangan
PLoS computational biology 13 (5), e1005525, 2017
562017
Widespread prion-based control of growth and differentiation strategies in Saccharomyces cerevisiae
AK Itakura, AK Chakravarty, CM Jakobson, DF Jarosz
Molecular cell 77 (2), 266-278. e6, 2020
482020
Quantitative characterization of all single amino acid variants of a viral capsid-based drug delivery vehicle
EC Hartman, CM Jakobson, AH Favor, MJ Lobba, E Álvarez-Benedicto, ...
Nature communications 9 (1), 1385, 2018
462018
A selection for assembly reveals that a single amino acid mutant of the bacteriophage MS2 coat protein forms a smaller virus-like particle
MA Asensio, NM Morella, CM Jakobson, EC Hartman, JE Glasgow, ...
Nano letters 16 (9), 5944-5950, 2016
442016
Dumpster diving in the gut: bacterial microcompartments as part of a host-associated lifestyle
CM Jakobson, D Tullman-Ercek
PLoS pathogens 12 (5), e1005558, 2016
432016
De novo design of signal sequences to localize cargo to the 1,2‐propanediol utilization microcompartment
CM Jakobson, MF Slininger Lee, D Tullman‐Ercek
Protein Science 26 (5), 1086-1092, 2017
392017
Engineering transcriptional regulation to control Pdu microcompartment formation
EY Kim, CM Jakobson, D Tullman-Ercek
PloS one 9 (11), e113814, 2014
282014
Tuning the catalytic activity of subcellular nanoreactors
CM Jakobson, Y Chen, MF Slininger, E Valdivia, EY Kim, ...
Journal of Molecular Biology 428 (15), 2989-2996, 2016
272016
Molecular origins of complex heritability in natural genotype-to-phenotype relationships
CM Jakobson, DF Jarosz
Cell Systems 8 (5), 363-379. e3, 2019
252019
Organizing biochemistry in space and time using prion-like self-assembly
CM Jakobson, DF Jarosz
Current opinion in systems biology 8, 16-24, 2018
202018
A prion accelerates proliferation at the expense of lifespan
DM Garcia, EA Campbell, CM Jakobson, M Tsuchiya, EA Shaw, ...
Elife 10, e60917, 2021
182021
Spatially organizing biochemistry: choosing a strategy to translate synthetic biology to the factory
CM Jakobson, D Tullman-Ercek, NM Mangan
Scientific reports 8 (1), 8196, 2018
152018
What has a century of quantitative genetics taught us about nature's genetic tool kit?
CM Jakobson, DF Jarosz
Annual Review of Genetics 54, 439-464, 2020
132020
Pervasive function and evidence for selection across standing genetic variation in S. cerevisiae
CM Jakobson, R She, DF Jarosz
Nature Communications 10 (1), 1222, 2019
132019
Metabolites control stress granule disassembly
CM Jakobson, DF Jarosz
Nature Cell Biology 23 (10), 1053-1055, 2021
22021
An estimate is worth about a thousand experiments: using order-of-magnitude estimates to identify cellular engineering targets
KJ Metcalf, MF Slininger Lee, CM Jakobson, D Tullman-Ercek
Microbial Cell Factories 17, 1-10, 2018
12018
Hsp90 shapes adaptation by controlling the fitness consequences of regulatory variation
CM Jakobson, J Aguilar-Rodríguez, DF Jarosz
bioRxiv, 2023
2023
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