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James Saville
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SARS-CoV-2 Omicron variant: Antibody evasion and cryo-EM structure of spike protein–ACE2 complex
D Mannar, JW Saville, X Zhu, SS Srivastava, AM Berezuk, KS Tuttle, ...
Science 375 (6582), 760-764, 2022
5142022
Cryo-electron microscopy structures of the N501Y SARS-CoV-2 spike protein in complex with ACE2 and 2 potent neutralizing antibodies
X Zhu, D Mannar, SS Srivastava, AM Berezuk, JP Demers, JW Saville, ...
PLoS biology 19 (4), e3001237, 2021
1852021
Structural and biochemical rationale for enhanced spike protein fitness in delta and kappa SARS-CoV-2 variants
JW Saville, D Mannar, X Zhu, SS Srivastava, AM Berezuk, JP Demers, ...
Nature communications 13 (1), 742, 2022
752022
Structural analysis of receptor binding domain mutations in SARS-CoV-2 variants of concern that modulate ACE2 and antibody binding
D Mannar, JW Saville, X Zhu, SS Srivastava, AM Berezuk, S Zhou, ...
Cell reports 37 (12), 2021
742021
SARS-CoV-2 variants of concern: spike protein mutational analysis and epitope for broad neutralization
D Mannar, JW Saville, Z Sun, X Zhu, MM Marti, SS Srivastava, ...
Nature Communications 13 (1), 4696, 2022
39*2022
Sars-cov-2 omicron variant: Ace2 binding, cryo-em structure of spike protein-ace2 complex and antibody evasion
D Mannar, JW Saville, X Zhu, SS Srivastava, AM Berezuk, KS Tuttle, ...
BioRxiv, 2021.12. 19.473380, 2021
332021
SARS-CoV-2 Omicron Variant: ACE2 Binding
D Mannar, JW Saville, X Zhu, SS Srivastava, AM Berezuk, KS Tuttle, ...
Cryo-EM Structure of Spike Protein-ACE2 Complex and Antibody Evasion …, 2021
172021
Three-dimensional visualization of viral structure, entry, and replication underlying the spread of SARS-CoV-2
JW Saville, AM Berezuk, SS Srivastava, S Subramaniam
Chemical reviews 122 (17), 14066-14084, 2022
162022
Structural analysis of receptor engagement and antigenic drift within the BA. 2 spike protein
JW Saville, D Mannar, X Zhu, AM Berezuk, S Cholak, KS Tuttle, ...
Cell Reports 42 (1), 2023
112023
PeptiQuick, a One-Step Incorporation of Membrane Proteins into Biotinylated Peptidiscs for Streamlined Protein Binding Assays
JW Saville, L Troman, FD Van Hoa
JoVE (Journal of Visualized Experiments), e60661, 2019
102019
Development and field validation of lidocaine-loaded castration bands for bovine pain mitigation
JW Saville, JA Ross, T Trefz, C Schatz, H Matheson-Bird, B Ralston, ...
Animals 10 (12), 2363, 2020
52020
Allosteric modulation of ryanodine receptor RyR1 by nucleotide derivatives
S Cholak, JW Saville, X Zhu, AM Berezuk, KS Tuttle, O Haji-Ghassemi, ...
Structure 31 (7), 790-800. e4, 2023
42023
[GaX2(dmpe)2][GaX4] (X = Cl, Br, I): a synthetic, solid state, and computational study
PA Gray, JW Saville, KD Krause, N Burford, R McDonald, MJ Ferguson
Canadian Journal of Chemistry 95 (4), 346-350, 2017
32017
Altered receptor binding, antibody evasion and retention of T cell recognition by the SARS-CoV-2 XBB. 1.5 spike protein
D Mannar, JW Saville, C Poloni, X Zhu, A Bezeruk, K Tidey, S Ahmed, ...
Nature Communications 15 (1), 1854, 2024
12024
Potent and broad neutralization of SARS-CoV-2 variants of concern (VOCs) including omicron sub-lineages BA. 1 and BA. 2 by biparatopic human VH domains
C Chen, JW Saville, MM Marti, A Schäfer, MH Cheng, D Mannar, X Zhu, ...
Iscience 25 (8), 2022
1*2022
Molecular mechanisms of SARS-CoV-2 variant spike proteins
JW Saville
University of British Columbia, 2023
2023
Structure-Function Rationale for Enhanced Viral Fitness in SARS-CoV-2 Variants of Concern
J Saville, D Mannar, X Zhu, W Li, A Berezuk, K Tuttle, S Cholak, ...
Protein Science, 2023
2023
Allosteric Modulation of RyR1 with Nucleotide Analogs
S Cholak, J Saville, X Zhu, A Berezuk, O Haji-Ghassemi, K Tuttle, ...
PROTEIN SCIENCE 32, 2023
2023
SARS-CoV-2 Omicron Variant: ACE2 Binding, Cryo-EM Structure of Spike Protein-ACE2 Complex and Antibody Evasion (preprint)
D Mannar, JW Saville, X Zhu, SS Srivastava, AM Berezuk, K Tuttle, ...
2021
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