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Markus Friden
Markus Friden
RIA iMed, AstraZeneca
Verified email at astrazeneca.com
Title
Cited by
Cited by
Year
On the rate and extent of drug delivery to the brain
M Hammarlund-Udenaes, M Fridén, S Syvänen, A Gupta
Pharmaceutical research 25, 1737-1750, 2008
5192008
Structure− brain exposure relationships in rat and human using a novel data set of unbound drug concentrations in brain interstitial and cerebrospinal fluids
M Fridén, S Winiwarter, G Jerndal, O Bengtsson, H Wan, U Bredberg, ...
Journal of medicinal chemistry 52 (20), 6233-6243, 2009
2302009
In vitro methods for estimating unbound drug concentrations in the brain interstitial and intracellular fluids
M Friden, A Gupta, M Antonsson, U Bredberg, M Hammarlund-Udenaes
Drug metabolism and disposition 35 (9), 1711-1719, 2007
2082007
Measurement of unbound drug exposure in brain: modeling of pH partitioning explains diverging results between the brain slice and brain homogenate methods
M Fridén, F Bergström, H Wan, M Rehngren, G Ahlin, ...
Drug Metabolism and Disposition 39 (3), 353-362, 2011
1772011
Development of a high-throughput brain slice method for studying drug distribution in the central nervous system
M Friden, F Ducrozet, B Middleton, M Antonsson, U Bredberg, ...
Drug metabolism and disposition 37 (6), 1226-1233, 2009
1452009
Improved measurement of drug exposure in the brain using drug-specific correction for residual blood
M Fridén, H Ljungqvist, B Middleton, U Bredberg, ...
Journal of Cerebral Blood Flow & Metabolism 30 (1), 150-161, 2010
1172010
The brain slice method for studying drug distribution in the CNS
I Loryan, M Fridén, M Hammarlund-Udenaes
Fluids and Barriers of the CNS 10, 1-9, 2013
902013
Methodologies to assess brain drug delivery in lead optimization
M Hammarlund-Udenaes, U Bredberg, M Fridén
Current topics in medicinal chemistry 9 (2), 148-162, 2009
822009
Systems pharmacology approach for prediction of pulmonary and systemic pharmacokinetics and receptor occupancy of inhaled drugs
E Boger, N Evans, M Chappell, A Lundqvist, P Ewing, A Wigenborg, ...
CPT: pharmacometrics & systems pharmacology 5 (4), 201-210, 2016
782016
In silico prediction of unbound brain-to-plasma concentration ratio using machine learning algorithms
H Chen, S Winiwarter, M Fridén, M Antonsson, O Engkvist
Journal of Molecular Graphics and Modelling 29 (8), 985-995, 2011
672011
Physiologically based pharmacokinetic/pharmacodynamic modeling accurately predicts the better bronchodilatory effect of inhaled versus oral salbutamol dosage forms
E Boger, M Fridén
Journal of aerosol medicine and pulmonary drug delivery 32 (1), 1-12, 2019
502019
Current progress toward a better understanding of drug disposition within the lungs: summary proceedings of the first workshop on drug transporters in the lungs
C Ehrhardt, P Bäckman, W Couet, C Edwards, B Forbes, M Fridén, ...
Journal of Pharmaceutical Sciences 106 (9), 2234-2244, 2017
462017
Development of a novel lung slice methodology for profiling of inhaled compounds
E Bäckström, A Lundqvist, E Boger, P Svanberg, P Ewing, ...
Journal of pharmaceutical sciences 105 (2), 838-845, 2016
462016
Unbound Brain-to-Plasma Partition Coefficient, Kp,uu,brain—a Game Changing Parameter for CNS Drug Discovery and Development
I Loryan, A Reichel, B Feng, C Bundgaard, C Shaffer, C Kalvass, ...
Pharmaceutical research 39 (7), 1321-1341, 2022
422022
Translational model to predict pulmonary pharmacokinetics and efficacy in man for inhaled bronchodilators
R Hendrickx, E Lamm Bergström, DLI Janzén, M Fridén, U Eriksson, ...
CPT: pharmacometrics & systems pharmacology 7 (3), 147-157, 2018
382018
Exploring in silico prediction of the unbound brain-to-plasma drug concentration ratio: model validation, renewal, and interpretation
S Varadharajan, S Winiwarter, L Carlsson, O Engkvist, A Anantha, ...
Journal of Pharmaceutical Sciences 104 (3), 1197-1206, 2015
372015
Identification of positron emission tomography (PET) tracer candidates by prediction of the target-bound fraction in the brain
M Fridén, M Wennerberg, M Antonsson, M Sandberg-Ställ, L Farde, ...
EJNMMI research 4, 1-8, 2014
362014
Lung retention by lysosomal trapping of inhaled drugs can be predicted in vitro with lung slices
E Bäckström, E Boger, A Lundqvist, M Hammarlund-Udenaes, M Fridén
Journal of pharmaceutical sciences 105 (11), 3432-3439, 2016
292016
Deep learning with conformal prediction for hierarchical analysis of large-scale whole-slide tissue images
H Wieslander, PJ Harrison, G Skogberg, S Jackson, M Fridén, J Karlsson, ...
IEEE journal of biomedical and health informatics 25 (2), 371-380, 2020
282020
Pharmacokinetic considerations of nanodelivery to the brain: Using modeling and simulations to predict the outcome of liposomal formulations
A Lindqvist, M Fridén, M Hammarlund-Udenaes
European Journal of Pharmaceutical Sciences 92, 173-182, 2016
282016
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