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Leonard Buckbinder
Leonard Buckbinder
Vice President, Biology; Scorpion Therapeutics
Verified email at scorpiontx.com
Title
Cited by
Cited by
Year
Induction of the growth inhibitor IGF-binding protein 3 by p53
L Buckbinder, R Talbott, S Velasco-Miguel, I Takenaka, B Faha, ...
Nature 377 (6550), 646-649, 1995
12311995
Genome-wide association and Mendelian randomisation analysis provide insights into the pathogenesis of heart failure
S Shah, A Henry, C Roselli, H Lin, G Sveinbjörnsson, G Fatemifar, ...
Nature communications 11 (1), 163, 2020
5302020
NF-κB RelA phosphorylation regulates RelA acetylation
LF Chen, SA Williams, Y Mu, H Nakano, JM Duerr, L Buckbinder, ...
Molecular and cellular biology 25 (18), 7966-7975, 2005
5282005
PA26, a novel target of the p53 tumor suppressor and member of the GADD family of DNA damage and growth arrest inducible genes
S Velasco-Miguel, L Buckbinder, P Jean, L Gelbert, R Talbott, J Laidlaw, ...
Oncogene 18 (1), 127-137, 1999
2931999
The initiator directs the assembly of a transcription factor IID-dependent transcription complex.
J Carcamo, L Buckbinder, D Reinberg
Proceedings of the National Academy of Sciences 88 (18), 8052-8056, 1991
2461991
Proline-rich tyrosine kinase 2 regulates osteoprogenitor cells and bone formation, and offers an anabolic treatment approach for osteoporosis
L Buckbinder, DT Crawford, H Qi, HZ Ke, LM Olson, KR Long, ...
Proceedings of the National Academy of Sciences 104 (25), 10619-10624, 2007
1772007
Thyroid hormone-induced gene expression changes in the developing frog limb.
L Buckbinder, DD Brown
Journal of Biological Chemistry 267 (36), 25786-25791, 1992
1271992
The p53 tumor suppressor targets a novel regulator of G protein signaling
L Buckbinder, S Velasco-Miguel, Y Chen, N Xu, R Talbott, L Gelbert, ...
Proceedings of the National Academy of Sciences 94 (15), 7868-7872, 1997
1261997
Expression of the Xenopus laevis prolactin and thyrotropin genes during metamorphosis.
L Buckbinder, DD Brown
Proceedings of the National Academy of Sciences 90 (9), 3820-3824, 1993
1261993
Structural characterization of proline-rich tyrosine kinase 2 (PYK2) reveals a unique (DFG-out) conformation and enables inhibitor design
S Han, A Mistry, JS Chang, D Cunningham, M Griffor, PC Bonnette, ...
Journal of biological chemistry 284 (19), 13193-13201, 2009
1252009
Identification of novel pheno-groups in heart failure with preserved ejection fraction using machine learning
ÅK Hedman, C Hage, A Sharma, MJ Brosnan, L Buckbinder, LM Gan, ...
Heart 106 (5), 342-349, 2020
1082020
Myeloperoxidase inhibition improves ventricular function and remodeling after experimental myocardial infarction
M Ali, B Pulli, G Courties, B Tricot, M Sebas, Y Iwamoto, I Hilgendorf, ...
JACC: Basic to Translational Science 1 (7), 633-643, 2016
1082016
Gene regulation by temperature-sensitive p53 mutants: identification of p53 response genes.
L Buckbinder, R Talbott, BR Seizinger, N Kley
Proceedings of the National Academy of Sciences 91 (22), 10640-10644, 1994
1071994
Understanding the impact of the P-loop conformation on kinase selectivity
CRW Guimarães, BK Rai, MJ Munchhof, S Liu, J Wang, SK Bhattacharya, ...
Journal of chemical information and modeling 51 (6), 1199-1204, 2011
1012011
Endothelial protein kinase MAP4K4 promotes vascular inflammation and atherosclerosis
RJ Roth Flach, A Skoura, A Matevossian, LV Danai, W Zheng, C Cortes, ...
Nature communications 6 (1), 8995, 2015
992015
PF-1355, a mechanism-based myeloperoxidase inhibitor, prevents immune complex vasculitis and anti–glomerular basement membrane glomerulonephritis
W Zheng, R Warner, R Ruggeri, C Su, C Cortes, A Skoura, J Ward, K Ahn, ...
Journal of Pharmacology and Experimental Therapeutics 353 (2), 288-298, 2015
852015
Sulfoximine-substituted trifluoromethylpyrimidine analogs as inhibitors of proline-rich tyrosine kinase 2 (PYK2) show reduced hERG activity
DP Walker, MP Zawistoski, MA McGlynn, JC Li, DW Kung, PC Bonnette, ...
Bioorganic & medicinal chemistry letters 19 (12), 3253-3258, 2009
852009
Factors involved in specific transcription by mammalian RNA polymerase II: Role of factors IID and MLTF in transcription from the adenovirus major late and IVa2 promoters
J Carcamo, S Lobos, A Merino, L Buckbinder, R Weinmann, V Natarajan, ...
Journal of Biological Chemistry 264 (13), 7704-7714, 1989
841989
Phosphorylation of cellular proteins regulates their binding to the cAMP response element
A Merino, L Buckbinder, FH Mermelstein, D Reinberg
Journal of Biological Chemistry 264 (35), 21266-21276, 1989
811989
The glucocorticoid receptor: molecular mechanism and new therapeutic opportunities
L Buckbinder, RP Robinson
Current Drug Targets-Inflammation & Allergy 1 (2), 127-136, 2002
792002
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