| A functional screen implicates microRNA-138-dependent regulation of the depalmitoylation enzyme APT1 in dendritic spine morphogenesis G Siegel, G Obernosterer, R Fiore, M Oehmen, S Bicker, M Christensen, ... Nature cell biology 11 (6), 705-716, 2009 | 487 | 2009 |
| Small-molecule inhibition of APT1 affects Ras localization and signaling FJ Dekker, O Rocks, N Vartak, S Menninger, C Hedberg, R Balamurugan, ... Nature chemical biology 6 (6), 449, 2010 | 308 | 2010 |
| Histone acetyl transferases as emerging drug targets FJ Dekker, HJ Haisma Drug discovery today 14 (19-20), 942-948, 2009 | 292 | 2009 |
| Exchange protein directly activated by cAMP (epac): a multidomain cAMP mediator in the regulation of diverse biological functions M Schmidt, FJ Dekker, H Maarsingh Pharmacological reviews 65 (2), 670-709, 2013 | 260 | 2013 |
| Histone acetyltransferases: challenges in targeting bi-substrate enzymes H Wapenaar, FJ Dekker Clinical epigenetics 8 (1), 59, 2016 | 122 | 2016 |
| Histone acetyltransferases are crucial regulators in NF-κB mediated inflammation M Ghizzoni, HJ Haisma, H Maarsingh, FJ Dekker Drug discovery today 16 (11-12), 504-511, 2011 | 122 | 2011 |
| Inflammation, cancer and oxidative lipoxygenase activity are intimately linked R Wisastra, FJ Dekker Cancers 6 (3), 1500-1521, 2014 | 111 | 2014 |
| Identification of acyl protein thioesterases 1 and 2 as the cellular targets of the Ras‐signaling modulators palmostatin B and M M Rusch, TJ Zimmermann, M Bürger, FJ Dekker, K Görmer, G Triola, ... Angewandte Chemie 123 (42), 10012-10016, 2011 | 106 | 2011 |
| Small molecule inhibitors of histone acetyltransferases and deacetylases are potential drugs for inflammatory diseases FJ Dekker, T van den Bosch, NI Martin Drug discovery today 19 (5), 654-660, 2014 | 103 | 2014 |
| 6-alkylsalicylates are selective Tip60 inhibitors and target the acetyl-CoA binding site M Ghizzoni, J Wu, T Gao, HJ Haisma, FJ Dekker, YG Zheng European journal of medicinal chemistry 47, 337-344, 2012 | 94 | 2012 |
| Light-controlled HDAC inhibitors: towards photopharmacological chemotherapy W Szymanski, ME Ourailidou, WA Velema, FJ Dekker, BL Feringa Chemistry (Weinheim an der Bergstrasse, Germany) 21 (46), 16517, 2015 | 81 | 2015 |
| Improved inhibition of the histone acetyltransferase PCAF by an anacardic acid derivative M Ghizzoni, A Boltjes, C de Graaf, HJ Haisma, FJ Dekker Bioorganic & medicinal chemistry 18 (16), 5826-5834, 2010 | 76 | 2010 |
| Protein structure similarity clustering (PSSC) and natural product structure as inspiration sources for drug development and chemical genomics FJ Dekker, MA Koch, H Waldmann Current opinion in chemical biology 9 (3), 232-239, 2005 | 75 | 2005 |
| Design of compound libraries based on natural product scaffolds and protein structure similarity clustering (PSSC) R Balamurugan, FJ Dekker, H Waldmann Molecular BioSystems 1 (1), 36-45, 2005 | 74 | 2005 |
| Development of highly potent inhibitors of the Ras‐targeting human acyl protein thioesterases based on substrate similarity design C Hedberg, FJ Dekker, M Rusch, S Renner, S Wetzel, N Vartak, ... Angewandte Chemie International Edition 50 (42), 9832-9837, 2011 | 66 | 2011 |
| Engineering methylaspartate ammonia lyase for the asymmetric synthesis of unnatural amino acids H Raj, W Szymański, J De Villiers, HJ Rozeboom, VP Veetil, CR Reis, ... Nature Chemistry 4 (6), 478, 2012 | 63 | 2012 |
| Inhibiting the palmitoylation/depalmitoylation cycle selectively reduces the growth of hematopoietic cells expressing oncogenic Nras J Xu, C Hedberg, FJ Dekker, Q Li, KM Haigis, E Hwang, H Waldmann, ... Blood, The Journal of the American Society of Hematology 119 (4), 1032-1035, 2012 | 62 | 2012 |
| Histone deacetylase 3 (HDAC 3) as emerging drug target in NF-κB-mediated inflammation NGJ Leus, MRH Zwinderman, FJ Dekker Current opinion in chemical biology 33, 160-168, 2016 | 58 | 2016 |
| HDAC 3-selective inhibitor RGFP966 demonstrates anti-inflammatory properties in RAW 264.7 macrophages and mouse precision-cut lung slices by attenuating NF-κB p65 … NGJ Leus, PE van der Wouden, T van den Bosch, WTR Hooghiemstra, ... Biochemical pharmacology 108, 58-74, 2016 | 57 | 2016 |
| Inhibition of the PCAF histone acetyl transferase and cell proliferation by isothiazolones FJ Dekker, M Ghizzoni, N van der Meer, R Wisastra, HJ Haisma Bioorganic & medicinal chemistry 17 (2), 460-466, 2009 | 53 | 2009 |
