CD22 is a negative regulator of B-cell receptor signalling L Nitschke, R Carsetti, B Ocker, G Köhler, MC Lamers Current Biology 7 (2), 133-143, 1997 | 508 | 1997 |
B cell-specific deletion of protein-tyrosine phosphatase Shp1 promotes B-1a cell development and causes systemic autoimmunity LI Pao, KP Lam, JM Henderson, JL Kutok, M Alimzhanov, L Nitschke, ... Immunity 27 (1), 35-48, 2007 | 293 | 2007 |
The role of CD22 and other inhibitory co-receptors in B-cell activation L Nitschke Current opinion in immunology 17 (3), 290-297, 2005 | 255 | 2005 |
The murine inhibitory receptor mSiglec‐E is expressed broadly on cells of the innate immune system whereas mSiglec‐F is restricted to eosinophils JQ Zhang, B Biedermann, L Nitschke, PR Crocker European journal of immunology 34 (4), 1175-1184, 2004 | 223 | 2004 |
The ligand-binding domain of CD22 is needed for inhibition of the B cell receptor signal, as demonstrated by a novel human CD22-specific inhibitor compound S Kelm, J Gerlach, R Brossmer, CP Danzer, L Nitschke The Journal of experimental medicine 195 (9), 1207-1213, 2002 | 207 | 2002 |
Siglec-G is a B1 cell–inhibitory receptor that controls expansion and calcium signaling of the B1 cell population A Hoffmann, S Kerr, J Jellusova, J Zhang, F Weisel, U Wellmann, ... Nature immunology 8 (7), 695-704, 2007 | 206 | 2007 |
Compensation between Vav-1 and Vav-2 in B cell development and antigen receptor signaling K Tedford, L Nitschke, I Girkontaite, A Charlesworth, G Chan, V Sakk, ... Nature immunology 2 (6), 548-555, 2001 | 197 | 2001 |
CD22 and Siglec‐G: B‐cell inhibitory receptors with distinct functions L Nitschke Immunological reviews 230 (1), 128-143, 2009 | 189 | 2009 |
Reduction of marginal zone B cells in CD22‐deficient mice T Samardzic, D Marinkovic, CP Danzer, J Gerlach, L Nitschke, T Wirth European journal of immunology 32 (2), 561-567, 2002 | 168 | 2002 |
Immunoglobulin D-deficient mice can mount normal immune responses to thymus-independent and-dependent antigens. L Nitschke, MH Kosco, G Köhler, MC Lamers Proceedings of the National Academy of Sciences 90 (5), 1887-1891, 1993 | 159 | 1993 |
Effect of transmembrane and cytoplasmic domains of IgE on the IgE response G Achatz, L Nitschke, MC Lamers Science 276 (5311), 409-411, 1997 | 156 | 1997 |
CD22× Siglec-G double-deficient mice have massively increased B1 cell numbers and develop systemic autoimmunity J Jellusova, U Wellmann, K Amann, TH Winkler, L Nitschke The Journal of Immunology 184 (7), 3618-3627, 2010 | 142 | 2010 |
NFATc1 affects mouse splenic B cell function by controlling the calcineurin–NFAT signaling network S Bhattacharyya, J Deb, AK Patra, DA Thuy Pham, W Chen, M Vaeth, ... Journal of Experimental Medicine 208 (4), 823-839, 2011 | 136 | 2011 |
Regulation of B cell functions by the sialic acid-binding receptors siglec-G and CD22 J Jellusova, L Nitschke Frontiers in immunology 2, 96, 2012 | 133 | 2012 |
Identification of CD22 ligands on bone marrow sinusoidal endothelium implicated in CD22-dependent homing of recirculating B cells L Nitschke, H Floyd, DJP Ferguson, PR Crocker The Journal of experimental medicine 189 (9), 1513-1518, 1999 | 131 | 1999 |
IgG1 B cell receptor signaling is inhibited by CD22 and promotes the development of B cells whose survival is less dependent on Igα/β A Waisman, M Kraus, J Seagal, S Ghosh, D Melamed, J Song, Y Sasaki, ... The Journal of experimental medicine 204 (4), 747-758, 2007 | 126 | 2007 |
Responsiveness of B cells is regulated by the hinge region of IgD R Übelhart, E Hug, MP Bach, T Wossning, M Dühren-von Minden, ... Nature immunology 16 (5), 534-543, 2015 | 121 | 2015 |
Molecular interactions regulate BCR signal inhibition by CD22 and CD72 L Nitschke, T Tsubata Trends in immunology 25 (10), 543-550, 2004 | 112 | 2004 |
Naive CD8 T-cells initiate spontaneous autoimmunity to a sequestered model antigen of the central nervous system SY Na, Y Cao, C Toben, L Nitschke, C Stadelmann, R Gold, A Schimpl, ... Brain 131 (9), 2353-2365, 2008 | 110 | 2008 |
Forced usage of positively charged amino acids in immunoglobulin CDR-H3 impairs B cell development and antibody production GC Ippolito, RL Schelonka, M Zemlin, II Ivanov, R Kobayashi, C Zemlin, ... The Journal of experimental medicine 203 (6), 1567-1578, 2006 | 108 | 2006 |