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| Combinatorial biosynthesis of reduced polyketides KJ Weissman, PF Leadlay Nature reviews microbiology 3 (12), 925-936, 2005 | 600 | 2005 |
| How coenzyme B12 radicals are generated: the crystal structure of methylmalonyl-coenzyme A mutase at 2 Å resolution F Mancia, NH Keep, A Nakagawa, PF Leadlay, S McSweeney, ... Structure 4 (3), 339-350, 1996 | 598 | 1996 |
| Complete genome sequence of the erythromycin-producing bacterium Saccharopolyspora erythraea NRRL23338 M Oliynyk, M Samborskyy, JB Lester, T Mironenko, N Scott, S Dickens, ... Nature biotechnology 25 (4), 447-453, 2007 | 473 | 2007 |
| Giant plasmid-encoded polyketide synthases produce the macrolide toxin of Mycobacterium ulcerans TP Stinear, A Mve-Obiang, PLC Small, W Frigui, MJ Pryor, R Brosch, ... Proceedings of the National Academy of Sciences 101 (5), 1345-1349, 2004 | 449 | 2004 |
| A chain initiation factor common to both modular and aromatic polyketide synthases C Bisang, PF Long, J Corte´ s, J Westcott, J Crosby, AL Matharu, RJ Cox, ... Nature 401 (6752), 502-505, 1999 | 363 | 1999 |
| Repositioning of a domain in a modular polyketide synthase to promote specific chain cleavage J Cortes, KEH Wiesmann, GA Roberts, MJB Brown, J Staunton, ... Science 268 (5216), 1487-1489, 1995 | 343 | 1995 |
| Organization of the biosynthetic gene cluster for rapamycin in Streptomyces hygroscopicus: Analysis of the enzymatic domains in the modular polyketide synthase JF Aparicio, I Molnár, T Schwecke, A König, SF Haydock, LE Khaw, ... Gene 169 (1), 9-16, 1996 | 335 | 1996 |
| Engineering broader specificity into an antibiotic-producing polyketide synthase AFA Marsden, B Wilkinson, J Cortes, NJ Dunster, J Staunton, PF Leadlay Science 279 (5348), 199-202, 1998 | 329 | 1998 |
| Divergent sequence motifs correlated with the substrate specificity of (methyl) malonyl‐CoA: acyl carrier protein transacylase domains in modular polyketide synthases SF Haydock, JF Aparicio, I Molnár, T Schwecke, LE Khaw, A König, ... FEBS letters 374 (2), 246-248, 1995 | 300 | 1995 |
| A hybrid modular polyketide synthase obtained by domain swapping M Oliynyk, MJB Brown, J Cortés, J Staunton, PF Leadlay Chemistry & biology 3 (10), 833-839, 1996 | 287 | 1996 |
| The structure of docking domains in modular polyketide synthases RW Broadhurst, D Nietlispach, MP Wheatcroft, PF Leadlay, KJ Weissman Chemistry & biology 10 (8), 723-731, 2003 | 253 | 2003 |
| 6‐Deoxyerythronolide‐B synthase 2 from Saccharopolyspora erythraea Cloning of the structural gene, sequence analysis and inferred domain structure of the … DJ Bevitt, J Cortes, SF Haydock, PF Leadlay European Journal of Biochemistry 204 (1), 39-49, 1992 | 246 | 1992 |
| Role of type II thioesterases: evidence for removal of short acyl chains produced by aberrant decarboxylation of chain extender units ML Heathcote, J Staunton, PF Leadlay Chemistry & biology 8 (2), 207-220, 2001 | 230 | 2001 |
| Increasing the efficiency of heterologous promoters in actinomycetes CJ Wilkinson, ZA Hughes-Thomas, CJ Martin, I Bohm, T Mironenko, ... Journal of molecular microbiology and biotechnology 4 (4), 417-426, 2002 | 214 | 2002 |
| Stereospecific acyl transfers on the erythromycin-producing polyketide synthase AFA Marsden, P Caffrey, JF Aparicio, MS Loughran, J Staunton, ... Science 263 (5145), 378-380, 1994 | 210 | 1994 |
| Cloning and sequence analysis of genes involved in erythromycin biosynthesis in Saccharopolyspora erythraea: sequence similarities between EryG and a family … SF Haydock, JA Dowson, N Dhillon, GA Roberts, J Cortes, PF Leadlay Molecular and General Genetics MGG 230, 120-128, 1991 | 206 | 1991 |
| Biosynthesis of the angiogenesis inhibitor borrelidin by Streptomyces parvulus Tü4055: cluster analysis and assignment of functions C Olano, B Wilkinson, C Sánchez, SJ Moss, R Sheridan, V Math, ... Chemistry & biology 11 (1), 87-97, 2004 | 203 | 2004 |
| Combinatorial approaches to polyketide biosynthesis PF Leadlay Current Opinion in Chemical Biology 1 (2), 162-168, 1997 | 198 | 1997 |
| Organisation of the biosynthetic gene cluster for rapamycin in Streptomyces hygroscopicus: Analysis of genes flanking the polyketide synthase I Molnár, JF Aparicio, SF Haydock, LE Khaw, T Schwecke, A König, ... Gene 169 (1), 1-7, 1996 | 188 | 1996 |
