| Structures of the Escherichia coli ribosome with antibiotics bound near the peptidyl transferase center explain spectra of drug action JA Dunkle, L Xiong, AS Mankin, JHD Cate Proceedings of the national academy of sciences 107 (40), 17152-17157, 2010 | 498 | 2010 |
| Acquisition of a natural resistance gene renders a clinical strain of methicillin‐resistant Staphylococcus aureus resistant to the synthetic antibiotic linezolid SM Toh, L Xiong, CA Arias, MV Villegas, K Lolans, J Quinn, AS Mankin Molecular microbiology 64 (6), 1506-1514, 2007 | 437 | 2007 |
| How macrolide antibiotics work N Vázquez-Laslop, AS Mankin Trends in biochemical sciences 43 (9), 668-684, 2018 | 383 | 2018 |
| Macrolide antibiotics: binding site, mechanism of action, resistance M Gaynor, AS Mankin Current topics in medicinal chemistry 3 (9), 949-960, 2003 | 346 | 2003 |
| The site of action of oxazolidinone antibiotics in living bacteria and in human mitochondria KL Leach, SM Swaney, JR Colca, WG McDonald, JR Blinn, LM Thomasco, ... Molecular cell 26 (3), 393-402, 2007 | 344 | 2007 |
| Molecular mechanism of drug-dependent ribosome stalling N Vazquez-Laslop, C Thum, AS Mankin Molecular cell 30 (2), 190-202, 2008 | 298 | 2008 |
| Nucleotide biosynthesis is critical for growth of bacteria in human blood S Samant, H Lee, M Ghassemi, J Chen, JL Cook, AS Mankin, AA Neyfakh PLoS pathogens 4 (2), e37, 2008 | 289 | 2008 |
| Resistance mutations in 23 S rRNA identify the site of action of the protein synthesis inhibitor linezolid in the ribosomal peptidyl transferase center P Kloss, L Xiong, DL Shinabarger, AS Mankin Journal of molecular biology 294 (1), 93-101, 1999 | 288 | 1999 |
| The ribosomal peptidyl transferase center: structure, function, evolution, inhibition N Polacek, AS Mankin Critical reviews in biochemistry and molecular biology 40 (5), 285-311, 2005 | 272 | 2005 |
| Protein synthesis by ribosomes with tethered subunits C Orelle, ED Carlson, T Szal, T Florin, MC Jewett, AS Mankin Nature 524 (7563), 119-124, 2015 | 258 | 2015 |
| Ribosomal peptidyl transferase can withstand mutations at the putative catalytic nucleotide N Polacek, M Gaynor, A Yassin, AS Mankin Nature 411 (6836), 498-501, 2001 | 234 | 2001 |
| Oxazolidinone Resistance Mutations in 23S rRNA ofEscherichia coli Reveal the Central Region of Domain V as the Primary Site of Drug Action L Xiong, P Kloss, S Douthwaite, NM Andersen, S Swaney, ... Journal of bacteriology 182 (19), 5325-5331, 2000 | 231 | 2000 |
| Antibiotics and the ribosome T Tenson, A Mankin Molecular microbiology 59 (6), 1664-1677, 2006 | 211 | 2006 |
| The general mode of translation inhibition by macrolide antibiotics K Kannan, P Kanabar, D Schryer, T Florin, E Oh, N Bahroos, T Tenson, ... Proceedings of the National Academy of Sciences 111 (45), 15958-15963, 2014 | 207 | 2014 |
| A ketolide resistance mutation in domain II of 23S rRNA reveals the proximity of hairpin 35 to the peptidyl transferase centre L Xiong, S Shah, P Mauvais, AS Mankin Molecular microbiology 31 (2), 633-639, 1999 | 196 | 1999 |
| Cross-linking in the living cell locates the site of action of oxazolidinone antibiotics JR Colca, WG McDonald, DJ Waldon, LM Thomasco, RC Gadwood, ... Journal of Biological Chemistry 278 (24), 21972-21979, 2003 | 194 | 2003 |
| Programmed drug‐dependent ribosome stalling H Ramu, A Mankin, N Vazquez‐Laslop Molecular microbiology 71 (4), 811-824, 2009 | 183 | 2009 |
| Structures of proline-rich peptides bound to the ribosome reveal a common mechanism of protein synthesis inhibition MG Gagnon, RN Roy, IB Lomakin, T Florin, AS Mankin, TA Steitz Nucleic acids research 44 (5), 2439-2450, 2016 | 182 | 2016 |
| Binding site of macrolide antibiotics on the ribosome: new resistance mutation identifies a specific interaction of ketolides with rRNA G Garza-Ramos, L Xiong, P Zhong, A Mankin Journal of bacteriology 183 (23), 6898-6907, 2001 | 182 | 2001 |
| RlmN and Cfr are radical SAM enzymes involved in methylation of ribosomal RNA F Yan, JM LaMarre, R Röhrich, J Wiesner, H Jomaa, AS Mankin, ... Journal of the American Chemical Society 132 (11), 3953-3964, 2010 | 178 | 2010 |
Krishna KannanSenior Director, Telesis BioVerified email at telesisbio.com
