| A novel TALE nuclease scaffold enables high genome editing activity in combination with low toxicity C Mussolino, R Morbitzer, F Lütge, N Dannemann, T Lahaye, T Cathomen Nucleic acids research 39 (21), 9283-9293, 2011 | 1058 | 2011 |
| Rapid “open-source” engineering of customized zinc-finger nucleases for highly efficient gene modification ML Maeder, S Thibodeau-Beganny, A Osiak, DA Wright, RM Anthony, ... Molecular cell 31 (2), 294-301, 2008 | 964 | 2008 |
| Autosomal dominant immune dysregulation syndrome in humans with CTLA4 mutations D Schubert, C Bode, R Kenefeck, TZ Hou, JB Wing, A Kennedy, ... Nature medicine 20 (12), 1410-1416, 2014 | 870 | 2014 |
| Structure-based redesign of the dimerization interface reduces the toxicity of zinc-finger nucleases M Szczepek, V Brondani, J Büchel, L Serrano, DJ Segal, T Cathomen Nature biotechnology 25 (7), 786-793, 2007 | 647 | 2007 |
| Unexpected failure rates for modular assembly of engineered zinc fingers CL Ramirez, JE Foley, DA Wright, F Müller-Lerch, SH Rahman, TI Cornu, ... Nature methods 5 (5), 374-375, 2008 | 579 | 2008 |
| Zinc-finger nucleases: the next generation emerges T Cathomen, JK Joung Molecular Therapy 16 (7), 1200-1207, 2008 | 478 | 2008 |
| Differential integrity of TALE nuclease genes following adenoviral and lentiviral vector gene transfer into human cells M Holkers, I Maggio, J Liu, JM Janssen, F Miselli, C Mussolino, A Recchia, ... Nucleic acids research 41 (5), e63-e63, 2013 | 387 | 2013 |
| Measles viruses with altered envelope protein cytoplasmic tails gain cell fusion competence T Cathomen, HY Naim, R Cattaneo Journal of virology 72 (2), 1224-1234, 1998 | 356 | 1998 |
| TALE nucleases: tailored genome engineering made easy C Mussolino, T Cathomen Current opinion in biotechnology 23 (5), 644-650, 2012 | 350 | 2012 |
| A matrix‐less measles virus is infectious and elicits extensive cell fusion: consequences for propagation in the brain T Cathomen, B Mrkic, D Spehner, R Drillien, R Naef, J Pavlovic, A Aguzzi, ... The EMBO journal, 1998 | 327 | 1998 |
| DNA-binding specificity is a major determinant of the activity and toxicity of zinc-finger nucleases TI Cornu, S Thibodeau-Beganny, E Guhl, S Alwin, M Eichtinger, JK Joung, ... Molecular Therapy 16 (2), 352-358, 2008 | 307 | 2008 |
| Streptococcus thermophilus CRISPR-Cas9 systems enable specific editing of the human genome M Müller, CM Lee, G Gasiunas, TH Davis, TJ Cradick, V Siksnys, G Bao, ... Molecular Therapy 24 (3), 636-644, 2016 | 296 | 2016 |
| Refining strategies to translate genome editing to the clinic TI Cornu, C Mussolino, T Cathomen Nature medicine 23 (4), 415-423, 2017 | 276 | 2017 |
| Inactivation of hepatitis B virus replication in cultured cells and in vivo with engineered transcription activator-like effector nucleases K Bloom, A Ely, C Mussolino, T Cathomen, P Arbuthnot Molecular Therapy 21 (10), 1889-1897, 2013 | 256 | 2013 |
| TALENs facilitate targeted genome editing in human cells with high specificity and low cytotoxicity C Mussolino, J Alzubi, EJ Fine, R Morbitzer, TJ Cradick, T Lahaye, G Bao, ... Nucleic acids research 42 (10), 6762-6773, 2014 | 232 | 2014 |
| Engineered zinc finger nickases induce homology-directed repair with reduced mutagenic effects CL Ramirez, MT Certo, C Mussolino, MJ Goodwin, TJ Cradick, ... Nucleic acids research 40 (12), 5560-5568, 2012 | 231 | 2012 |
| Custom zinc-finger nucleases for use in human cells S Alwin, MB Gere, E Guhl, K Effertz, CF Barbas, DJ Segal, MD Weitzman, ... Molecular Therapy 12 (4), 610-617, 2005 | 218 | 2005 |
| Interaction of measles virus glycoproteins with the surface of uninfected peripheral blood lymphocytes induces immunosuppression in vitro J Schlender, JJ Schnorr, P Spielhofer, T Cathomen, R Cattaneo, ... Proceedings of the National Academy of Sciences 93 (23), 13194-13199, 1996 | 211 | 1996 |
| Efficient gene targeting mediated by adeno-associated virus and DNA double-strand breaks MH Porteus, T Cathomen, MD Weitzman, D Baltimore Molecular and cellular biology 23 (10), 3558-3565, 2003 | 200 | 2003 |
| Expanding or restricting the target site repertoire of zinc-finger nucleases: the inter-domain linker as a major determinant of target site selectivity EM Händel, S Alwin, T Cathomen Molecular Therapy 17 (1), 104-111, 2009 | 194 | 2009 |
Axel SchambachFull Professor, Hannover Medical SchoolVerified email at mh-hannover.de
