Tanya Tolmachova
Tanya Tolmachova
Research Fellow, Imperial College London
Bestätigte E-Mail-Adresse bei
Zitiert von
Zitiert von
Retinal gene therapy in patients with choroideremia: initial findings from a phase 1/2 clinical trial
RE MacLaren, M Groppe, AR Barnard, CL Cottriall, T Tolmachova, ...
The Lancet 383 (9923), 1129-1137, 2014
Exosome-delivered microRNAs modulate the inflammatory response to endotoxin
M Alexander, R Hu, MC Runtsch, DA Kagele, TL Mosbruger, ...
Nature communications 6 (1), 7321, 2015
MicroRNA-containing T-regulatory-cell-derived exosomes suppress pathogenic T helper 1 cells
IS Okoye, SM Coomes, VS Pelly, S Czieso, V Papayannopoulos, ...
Immunity 41 (1), 89-103, 2014
Rab27a regulates phagosomal pH and NADPH oxidase recruitment to dendritic cell phagosomes
C Jancic, A Savina, C Wasmeier, T Tolmachova, J El-Benna, PMC Dang, ...
Nature cell biology 9 (4), 367-378, 2007
Visual acuity after retinal gene therapy for choroideremia
TL Edwards, JK Jolly, M Groppe, AR Barnard, CL Cottriall, T Tolmachova, ...
New England Journal of Medicine 374 (20), 1996-1998, 2016
Rab27b regulates number and secretion of platelet dense granules
T Tolmachova, M Åbrink, CE Futter, KS Authi, MC Seabra
Proceedings of the National Academy of Sciences 104 (14), 5872-5877, 2007
Functional redundancy of Rab27 proteins and the pathogenesis of Griscelli syndrome
DC Barral, JS Ramalho, R Anders, AN Hume, HJ Knapton, T Tolmachova, ...
The Journal of clinical investigation 110 (2), 247-257, 2002
Beneficial effects on vision in patients undergoing retinal gene therapy for choroideremia
K Xue, JK Jolly, AR Barnard, A Rudenko, AP Salvetti, MI Patrício, ...
Nature medicine 24 (10), 1507-1512, 2018
A general role for Rab27a in secretory cells
T Tolmachova, R Anders, J Stinchcombe, G Bossi, GM Griffiths, C Huxley, ...
Molecular biology of the cell 15 (1), 332-344, 2004
Independent degeneration of photoreceptors and retinal pigment epithelium in conditional knockout mouse models of choroideremia
T Tolmachova, R Anders, M Abrink, L Bugeon, MJ Dallman, CE Futter, ...
The Journal of clinical investigation 116 (2), 386-394, 2006
Induced myelination and demyelination in a conditional mouse model of Charcot–Marie–Tooth disease type 1A
J Perea, A Robertson, T Tolmachova, J Muddle, RHM King, S Ponsford, ...
Human molecular genetics 10 (10), 1007-1018, 2001
Rab27b regulates mast cell granule dynamics and secretion
K Mizuno, T Tolmachova, DS Ushakov, M Romao, M Åbrink, MA Ferenczi, ...
Traffic 8 (7), 883-892, 2007
Rab27a and Rab27b regulate neutrophil azurophilic granule exocytosis and NADPH oxidase activity by independent mechanisms
JL Johnson, AA Brzezinska, T Tolmachova, DB Munafo, BA Ellis, ...
Traffic 11 (4), 533-547, 2010
Functional expression of Rab escort protein 1 following AAV2-mediated gene delivery in the retina of choroideremia mice and human cells ex vivo
T Tolmachova, OE Tolmachov, AR Barnard, SR de Silva, DM Lipinski, ...
Journal of molecular medicine 91, 825-837, 2013
Dual chemical probes enable quantitative system-wide analysis of protein prenylation and prenylation dynamics
EM Storck, J Morales-Sanfrutos, RA Serwa, N Panyain, T Lanyon-Hogg, ...
Nature Chemistry 11 (6), 552-561, 2019
Retinal pigment epithelium defects accelerate photoreceptor degeneration in cell type–specific knockout mouse models of choroideremia
T Tolmachova, ST Wavre-Shapton, AR Barnard, RE MacLaren, CE Futter, ...
Investigative ophthalmology & visual science 51 (10), 4913-4920, 2010
Rab27-dependent exosome production inhibits chronic inflammation and enables acute responses to inflammatory stimuli
M Alexander, AG Ramstead, KM Bauer, SH Lee, MC Runtsch, J Wallace, ...
The Journal of Immunology 199 (10), 3559-3570, 2017
Distinct and opposing roles for R ab27a/M lph/M yo V a and R ab27b/M unc13‐4 in mast cell secretion
RK Singh, K Mizuno, C Wasmeier, ST Wavre‐Shapton, C Recchi, SD Catz, ...
The FEBS journal 280 (3), 892-903, 2013
PtdIns3P and Rac direct the assembly of the NADPH oxidase on a novel, pre-phagosomal compartment during FcR-mediated phagocytosis in primary mouse neutrophils
KE Anderson, TAM Chessa, K Davidson, RB Henderson, S Walker, ...
Blood, The Journal of the American Society of Hematology 116 (23), 4978-4989, 2010
Conditional ablation of the choroideremia gene causes age-related changes in mouse retinal pigment epithelium
ST Wavre-Shapton, T Tolmachova, ML da Silva, CE Futter, MC Seabra
PloS one 8 (2), e57769, 2013
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