| Cellular mechanisms of insulin resistance GI Shulman The Journal of clinical investigation 106 (2), 171-176, 2000 | 3336 | 2000 |
| Impaired mitochondrial activity in the insulin-resistant offspring of patients with type 2 diabetes KF Petersen, S Dufour, D Befroy, R Garcia, GI Shulman New England Journal of Medicine 350 (7), 664-671, 2004 | 2236 | 2004 |
| Mitochondrial dysfunction and type 2 diabetes BB Lowell, GI Shulman Science 307 (5708), 384-387, 2005 | 2166 | 2005 |
| Mitochondrial dysfunction in the elderly: possible role in insulin resistance KF Petersen, D Befroy, S Dufour, J Dziura, C Ariyan, DL Rothman, ... Science 300 (5622), 1140-1142, 2003 | 2108 | 2003 |
| Insulin resistance and a diabetes mellitus-like syndrome in mice lacking the protein kinase Akt2 (PKBβ) H Cho, J Mu, JK Kim, JL Thorvaldsen, Q Chu, EB Crenshaw, KH Kaestner, ... Science 292 (5522), 1728-1731, 2001 | 2041 | 2001 |
| Disruption of IRS-2 causes type 2 diabetes in mice DJ Withers, JS Gutierrez, H Towery, DJ Burks, JM Ren, S Previs, Y Zhang, ... Nature 391 (6670), 900-904, 1998 | 1872 | 1998 |
| Inflammasome-mediated dysbiosis regulates progression of NAFLD and obesity J Henao-Mejia, E Elinav, C Jin, L Hao, WZ Mehal, T Strowig, CA Thaiss, ... Nature 482 (7384), 179-185, 2012 | 1804 | 2012 |
| Mechanisms for insulin resistance: common threads and missing links VT Samuel, GI Shulman Cell 148 (5), 852-871, 2012 | 1801 | 2012 |
| Mechanism of free fatty acid-induced insulin resistance in humans. M Roden, TB Price, G Perseghin, KF Petersen, DL Rothman, GW Cline, ... The Journal of clinical investigation 97 (12), 2859-2865, 1996 | 1774 | 1996 |
| Mechanism by which fatty acids inhibit insulin activation of insulin receptor substrate-1 (IRS-1)-associated phosphatidylinositol 3-kinase activity in muscle C Yu, Y Chen, GW Cline, D Zhang, H Zong, Y Wang, R Bergeron, JK Kim, ... Journal of Biological Chemistry 277 (52), 50230-50236, 2002 | 1663 | 2002 |
| Free fatty acids in obesity and type 2 diabetes: defining their role in the development of insulin resistance and β‐cell dysfunction G Boden, GI Shulman European journal of clinical investigation 32, 14-23, 2002 | 1605 | 2002 |
| Free fatty acid-induced insulin resistance is associated with activation of protein kinase C theta and alterations in the insulin signaling cascade. ME Griffin, MJ Marcucci, GW Cline, K Bell, N Barucci, D Lee, LJ Goodyear, ... Diabetes 48 (6), 1270-1274, 1999 | 1487 | 1999 |
| Effects of free fatty acids on glucose transport and IRS-1–associated phosphatidylinositol 3-kinase activity A Dresner, D Laurent, M Marcucci, ME Griffin, S Dufour, GW Cline, ... The Journal of clinical investigation 103 (2), 253-259, 1999 | 1474 | 1999 |
| Intramyocellular lipid concentrations are correlated with insulin sensitivity in humans: a 1H NMR spectroscopy study M Krssak, KF Petersen, A Dresner, L DiPietro, SM Vogel, DL Rothman, ... Diabetologia 42 (1), 113-116, 1999 | 1411 | 1999 |
| Mechanism of hepatic insulin resistance in non-alcoholic fatty liver disease VT Samuel, ZX Liu, X Qu, BD Elder, S Bilz, D Befroy, AJ Romanelli, ... Journal of Biological Chemistry 279 (31), 32345-32353, 2004 | 1405 | 2004 |
| Increased energy expenditure, decreased adiposity, and tissue-specific insulin sensitivity in protein-tyrosine phosphatase 1B-deficient mice LD Klaman, O Boss, OD Peroni, JK Kim, JL Martino, JM Zabolotny, ... Molecular and cellular biology 20 (15), 5479-5489, 2000 | 1372 | 2000 |
| Adipose-selective targeting of the GLUT4 gene impairs insulin action in muscle and liver ED Abel, O Peroni, JK Kim, YB Kim, O Boss, E Hadro, T Minnemann, ... Nature 409 (6821), 729-733, 2001 | 1368 | 2001 |
| Quantitation of muscle glycogen synthesis in normal subjects and subjects with non-insulin-dependent diabetes by 13C nuclear magnetic resonance spectroscopy GI Shulman, DL Rothman, T Jue, P Stein, RA DeFronzo, RG Shulman New England Journal of Medicine 322 (4), 223-228, 1990 | 1359 | 1990 |
| Loss of insulin signaling in hepatocytes leads to severe insulin resistance and progressive hepatic dysfunction MD Michael, RN Kulkarni, C Postic, SF Previs, GI Shulman, ... Molecular cell 6 (1), 87-97, 2000 | 1324 | 2000 |
| Obesity-associated improvements in metabolic profile through expansion of adipose tissue JY Kim, E Van De Wall, M Laplante, A Azzara, ME Trujillo, SM Hofmann, ... The Journal of clinical investigation 117 (9), 2621-2637, 2007 | 1238 | 2007 |
Douglas E BefroyYaleVerified email at yale.edu
