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| Impaired mitochondrial activity in the insulin-resistant offspring of patients with type 2 diabetes KF Petersen, S Dufour, D Befroy, R Garcia, GI Shulman New England Journal of Medicine 350 (7), 664-671, 2004 | 2275 | 2004 |
| Mitochondrial dysfunction and type 2 diabetes BB Lowell, GI Shulman Science 307 (5708), 384-387, 2005 | 2221 | 2005 |
| Mitochondrial dysfunction in the elderly: possible role in insulin resistance KF Petersen, D Befroy, S Dufour, J Dziura, C Ariyan, DL Rothman, ... Science 300 (5622), 1140-1142, 2003 | 2159 | 2003 |
| Insulin resistance and a diabetes mellitus-like syndrome in mice lacking the protein kinase Akt2 (PKBβ) H Cho, J Mu, JK Kim, JL Thorvaldsen, Q Chu, EB Crenshaw, KH Kaestner, ... Science 292 (5522), 1728-1731, 2001 | 2088 | 2001 |
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| Inflammasome-mediated dysbiosis regulates progression of NAFLD and obesity J Henao-Mejia, E Elinav, C Jin, L Hao, WZ Mehal, T Strowig, CA Thaiss, ... Nature 482 (7384), 179-185, 2012 | 1889 | 2012 |
| Mechanisms for insulin resistance: common threads and missing links VT Samuel, GI Shulman Cell 148 (5), 852-871, 2012 | 1860 | 2012 |
| Mechanism of free fatty acid-induced insulin resistance in humans. M Roden, TB Price, G Perseghin, KF Petersen, DL Rothman, GW Cline, ... The Journal of clinical investigation 97 (12), 2859-2865, 1996 | 1800 | 1996 |
| Mechanism by which fatty acids inhibit insulin activation of insulin receptor substrate-1 (IRS-1)-associated phosphatidylinositol 3-kinase activity in muscle C Yu, Y Chen, GW Cline, D Zhang, H Zong, Y Wang, R Bergeron, JK Kim, ... Journal of Biological Chemistry 277 (52), 50230-50236, 2002 | 1689 | 2002 |
| Free fatty acids in obesity and type 2 diabetes: defining their role in the development of insulin resistance and β‐cell dysfunction G Boden, GI Shulman European journal of clinical investigation 32, 14-23, 2002 | 1636 | 2002 |
| Effects of free fatty acids on glucose transport and IRS-1–associated phosphatidylinositol 3-kinase activity A Dresner, D Laurent, M Marcucci, ME Griffin, S Dufour, GW Cline, ... The Journal of clinical investigation 103 (2), 253-259, 1999 | 1505 | 1999 |
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| Loss of insulin signaling in hepatocytes leads to severe insulin resistance and progressive hepatic dysfunction MD Michael, RN Kulkarni, C Postic, SF Previs, GI Shulman, ... Molecular cell 6 (1), 87-97, 2000 | 1336 | 2000 |
| Obesity-associated improvements in metabolic profile through expansion of adipose tissue JY Kim, E Van De Wall, M Laplante, A Azzara, ME Trujillo, SM Hofmann, ... The Journal of clinical investigation 117 (9), 2621-2637, 2007 | 1275 | 2007 |
Rachel J. PerryAssistant Professor, Yale UniversityVerified email at yale.edu
